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Friday, August 26, 2016

Women Health: Endometriosis: The effects of Oral Contraceptive Pills on Circulatory System

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                          Endometriosis

During the last stage of the menstrual cycle, normally a layer of endometriosis lining on the inside of the uterus is expelled, known as menstruation blood, instead some of the endometriosis tissues grow somewhere in the body to cause endometriosis. Endometriosis also react to hormone signals of the monthly menstrual cycle, by building and breaking up tissues and eliminating them through menstrual period.

   The effects of Oral Contraceptive Pills on Circulatory System


1. High Blood Pressure(3)
More than 5% of women in US alone suffered from high blood pressure caused by intake of oral contraceptive combination pills. It often happens to women older than 35 years old and the risk is increasing with age. Study shows that estrogen in the oral contraceptive combination pill may cause the elevating of high blood pressure(1), and the progesterone only pill may cause the rise of diastolic pressure(2). Women who smoke while taking the birth control pill have greater risk of hypertension than non smokers(6).

2. Blood Clots(4)(5)(9)(10)
Estrogen in the oral contraceptive combination pill causes the increasing of certain chemicals that increase the risk of stickiness of platelets and blood clots in the veins in the body.

3. High level of cholesterol(3)(7)(8)
Woman who has high level of cholesterol in the body should take extra cautious while taking the oral contraceptive pill. Study shows that the pill may cause the rise of cholesterol levels in some women as resulting of high levels of estrogen caused by abnormal liver function.

4. Strokes(9)(10)(11)
If blood clots are allowed to accumulate for a prolong period of time in the veins of women taking the birth control bill, they may cause blockage of blood circulation that carries nutrients and oxygen for cells need resulting in increasing the risk of stroke.

5. Heart diseases(10)(11)
Blood clots in the veins cause the heart to work much harder to carry the nutrients and oxygen to the body's cells and waste from the cells. If this situation exists for a prolong period of time, it may increase high blood pressure and damage some parts in the heart resulting in heart diseases.

6. Hardening blood arteries(1)(12)
Study shows that oral contraceptive pill causes the atherosclerosis plaque build up in the arterial blood vessels. According to this study, the risk of stroke and heart diseases caused by high level of cholesterol and plaque formation increasing substantially to women taking the pill.

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References
(1) Peripheral arterial disease in a female using high-dose combined oral contraceptive pills by Pallavee P1, Samal S, Samal R.(PubMed)
(2) Cardiovascular disease in women: contraceptive issues and nonvalvular cardiovascular disease by Schrager S1, Dalby J, Hayon R, Fox K.(PubMed)
(3) Hypertension in women by August P.(PubMed)
(4) [Contraception in women with special problems].[Article in German] by Mueck A1, Neulen J, Thaler C, Birkhäuser M, Braendle W, Kiesel L, Kuhl H.(PubMed)
(5) Smoking and use of oral contraceptives: impact on thrombotic diseases by Lidegaard O.(PubMed)
(6) Blood Pressure, smoking and oral contraceptive control after cryptogenic stroke in young adults in the PFO-ASA Study by Arquizan C1, Touzé E, Moulin T, Woimant F, Ducrocq X, Mas JL; Patent Foramen Ovale and Atrial Septal Aneurysm Study Group.(PubMed)
(7) Worsening hypertriglyceridemia with oral contraceptive pills in an adolescent with HIV-associated lipodystrophy: a case report and review of the literature by Patni N, Diaz EG, Cabral MD, Siqueira LM, Diaz A.(PubMed)
(8) Lipid profile of women using oral contraceptive pills by Naz F1, Jyoti S, Akhtar N, Afzal M, Siddique YH.(PubMed)
(9) Risk of cardiovascular events with hormonal contraception: insights from the Danish cohort study by Lalude OO.(PubMed)
(10)Thrombotic diseases in young women and the influence of oral contraceptivesby Lidegaard O.(PubMed)
(11) Hormonal contraceptives and arterial disease: an epidemiological update by Plu-Bureau G1, Hugon-Rodin J, Maitrot-Mantelet L, Canonico M.(PubMed)
(12) Endothelial function across an oral contraceptive cycle in women using levonorgestrel and ethinyl estradiol by Torgrimson BN1, Meendering JR, Kaplan PF, Minson CT.(PubMed)

Thursday, August 25, 2016

Women Health: Endometriosis: The Good, Bad and Side effects of oral contraceptive pill

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                          Endometriosis

During the last stage of the menstrual cycle, normally a layer of endometriosis lining on the inside of the uterus is expelled, known as menstruation blood, instead some of the endometriosis tissues grow somewhere in the body to cause endometriosis. Endometriosis also react to hormone signals of the monthly menstrual cycle, by building and breaking up tissues and eliminating them through menstrual period.

       The Good, Bad and Side effects of oral contraceptive pill


The oral contraceptive pill is defined as one type of birth control pill containing both estrogen and progesterone that helps to control unwanted pregnancy and reducing symptoms of abdominal pain before, during or after menstrual cycle such as endometriosis, premenstrual symptoms etc.

The pill is taken 21 days on, 7 day off.
1. The intention
a) It will help to reduce the bleeding by thinning the endometrial lining and reducing the flow of the period blood that help to decreases the risk of retrograde menstruation in endometriosis.
b) It also helps to inhibit hormone prostaglandins that causes muscle spasm in the ovary reducing the menstrual cramps(5)(7).
c) Since the pill reduces the heavy bleeding(6) of endometriosis, it is lesser the risk of bleeding into cysts and pelvic cavity.
d) Managing the endometriosis(8) by creating a continual pregnant-like state.
e) Reduced menstrual symptoms, such as headaches, genital irritation, tiredness, bloating(7).

2. Risks and side effects
a) Risks
i) Since the oral contraceptive combination pill contains estrogen, it may cause blood clots(3), stroke(3), heart disease(1) and induced breast cancer(2)
ii) Hypertension(1) and increase heart rate(1) caused by thickening of blood in arteries.
b) Side effects
i) Bleeding and spotting(4) as our body needs time to adjust to the substance in the pill, Normally, the bleeding and spotting will end in six months.
ii) Weigh gain(9)(10)(11)(inconclusive result) caused by synthetic progesterone in the pill in some women.

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References
(1) Prospective measurement of blood pressure and heart rate over 24 h in women using combined oral contraceptives with estradiol by Grandi G1, Xholli A1, Napolitano A1, Piacenti I1, Bellafronte M1, Cagnacci A2.(PubMed)
(2) Correlation of age at oral contraceptive pill start with age at breast cancerdiagnosis by Imkampe AK1, Bates T.(PubMed)
(3) Cerebral vein thrombosis in women using short course oral contraceptiveconsumption by Sasannejad P1, Mellat Ardekani A2, Velayati A1, Shoeibi A1, Saeidi M1, Foroughipour M1,Azarpazhooh MR1.(PubMed)
(4) Phase 3 study of desogestrel and ethinyl estradiol combined oral contraceptivefor pregnancy prevention by Kroll R1, Howard B, Hsieh J, Ricciotti N.(PubMed)
(5) Progestogen-only contraceptive pill compared with combined oral contraceptivein the treatment of pain symptoms caused by endometriosis in patients with migraine without aura by Morotti M1, Remorgida V2, Venturini PL2, Ferrero S2.(PubMed)
(6) Treatment of heavy menstrual bleeding with the estradiol valerate and dienogest oral contraceptive pill by Micks EA1, Jensen JT.(PubMed)
(7) Continuous or extended cycle vs. cyclic use of combined oral contraceptivesfor contraception by Edelman AB1, Gallo MF, Jensen JT, Nichols MD, Schulz KF, Grimes DA(PubMed)
(8) contraceptive health benefits: perception versus reality by Kaunitz AM.(PubMed)
(9)Oral contraceptives use and weight gain in women with a Central European life-style by Lech MM1, Ostrowska L.(PubMed)
(10) Weight and body composition changes during oral contraceptive use in obese and normal weight women by Mayeda ER1, Torgal AH, Westhoff CL.(PubMed)
(11) An exploratory analysis of associations between eating disordered symptoms, perceived weight changes, and oral contraceptive discontinuation among young minority women by Hall KS1, White KO, Rickert VI, Reame NK, Westhoff CL.(PubMed)

Wednesday, August 24, 2016

Women Health: Endometriosis: The Types, Side Effect and Risks of Progesterone agonist

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                          Endometriosis


During the last stage of the menstrual cycle, normally a layer of endometriosis lining on the inside of the uterus is expelled, known as menstruation blood, instead some of the endometriosis tissues grow somewhere in the body to cause endometriosis. Endometriosis also react to hormone signals of the monthly menstrual cycle, by building and breaking up tissues and eliminating them through menstrual period.


The Types, Side Effect and Risks of Progesterone agonist


Progesterone agonist contains no estrogen, also known as the progesterone-like pill or progestins, it helps to maintain milk production for breastfeeding mother and to thicken the cervical mucus, thereby preventing sperm from entering the uterus. This type of pill must be taken at a certain time every 24 hours for effectively.
I. Types of Progesterone medicines
a) Injecting medicine
Type of progesterone medication injected in the women body every three months, such as Depo Provera. It is good for women who want to have long term contraception, it may work well for some women but study shows that it causes bone loss and sometimes osteoporosis(2).
b) Implant medicine(4)
The other type of progesterone like medicine such as Implanon is implanted into the fat of a non dominant arm and last about 3 years. It may not cause bone loss as Depo Provera, but it causes male like pattern such as excessive hair growth and deepening the voice.
c) Oral Progesterone-like pills(1)(2)
i) Progesterone like pill in treating excessive menstruation
If a woman does not have progesterone irregularity, her doctor may prescribe this type of medicine for her. It helps to complete shredding of the endometrium and stops the abnormal bleeding. Besides all the good thing of this type of progesterone like pill, it also has it side effects, such as utilizing in nicotine addiction, traumatic brain injury (recently entered Phase III trial) and Alzheimer's disease, diabetic neuropathy and crush injuries(5).
ii) Other types
Other types of progesterone like medicines, such as Provera, Duphaston, they helps to relieve of menstrual cramp with no long term serious side effects by creating the pregnancy-like state but their short term side effects including spotting and bleeding, return of menses (2).

II. Side effects
Most side effects are caused by high levels of progesterone for women taking the progesterone only pill, such as
1) Anxiety and Mood swing(7)(8)
2) Weight gain(6)
3) Reduced libido(7)(8)
4) Fluid retention(9)
5) Acne(3)
6) Breast tenderness(16)
7) Oedema(3)
8) Hot flush(3)

III. Risks
1) Ectopic pregnancy
Women taking the progesterone only pill may increase the risk of pregnancy inside the fallopian tube
2) Progesterone only pill may increase the risk of pain in the lower abdomen(4), shortly after a missed or light period.
3) It also increases the risk of developing small, benign cysts in the ovary(13).
4) Breast(10), endometrial(11)(12) cancer(13)
5) Uterine fibroids(13)
 
References
(1) New trends of progestins treatment of endometriosis.by Angioni S1, Cofelice V, Pontis A, Tinelli R, Socolov R.(PubMed)
(2) The role of progestins in treating the pain of endometriosis.by Surrey ES.(PubMed)
(3) Progestagens and anti-progestagens for pain associated with endometriosis by Brown J1, Kives S, Akhtar M.(PubMed)
(4)Endometriosis: pathogenesis and treatment by Vercellini P1, Viganò P2, Somigliana E1, Fedele L1.(PubMed)
(5) Novel actions of progesterone: what we know today and what will be the scenario in the future?by Kaore SN1, Langade DK, Yadav VK, Sharma P, Thawani VR, Sharma R.(PubMed)
(6) Weight change at 12 months in users of three progestin-only contraceptive methods by Vickery Z1, Madden T, Zhao Q, Secura GM, Allsworth JE, Peipert JF.(PubMed)
(7) Sexual function, mood and menopause symptoms in Lithuanian postmenopausal women by Jonusiene G1, Zilaitiene B, Adomaitiene V, Aniuliene R, Bancroft J.(PubMed)
(8)Relation of androgen receptor sensitivity and mood to sexual desire in hormonal contraception users by Elaut E1, Buysse A, De Sutter P, De Cuypere G, Gerris J, Deschepper E, T'Sjoen G.(PubMed)
(9) Calculated effect of fluid retention upon velocity of blood flow and turbulence: implications for atherosclerosis by Blankfield RP.(PubMed)
(10) Progestins and progesterone in hormone replacement therapy and the risk ofbreast cancer by Campagnoli C1, Clavel-Chapelon F, Kaaks R, Peris C, Berrino F.(PubMed)
(11) Risk of endometrial cancer following estrogen replacement with and withoutprogestins by Weiderpass E1, Adami HO, Baron JA, Magnusson C, Bergström R, Lindgren A, Correia N, Persson I.(PubMed)
(12) Risks of Endometrial Cancer Associated With Different Hormone Replacement Therapies in the E3N Cohort, 1992-2008 by Fournier A, Dossus L, Mesrine S, Vilier A, Boutron-Ruault MC, Clavel-Chapelon F, Chabbert-Buffet N.(PubMed)
(13) Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer by Kim JJ1, Kurita T, Bulun SE.(PubMed)
(14) [Ectopic pregnancy under Implanon contraception: a case of encysted haematocele].

[Article in French] by Mbarki C, Hsayaoui N, Ben Abdelaziz A, Khediri Z, Najjar M, Souai A, Somai M, Mezghenni S, Oueslati H.(PubMed)
(15) High progesterone levels and ciliary dysfunction--a possible cause of ectopic pregnancy by Paltieli Y1, Eibschitz I, Ziskind G, Ohel G, Silbermann M, Weichselbaum A.(PubMed)
(16) Types of progestogens in combined oral contraception: effectiveness and side-effects by Lawrie TA1, Helmerhorst FM, Maitra NK, Kulier R, Bloemenkamp K, Gülmezoglu AM.(PubMed)

Tuesday, August 23, 2016

Women Health: Endometriosis: The Good, The Bad and The Side Effects of The Pill

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                          Endometriosis

During the last stage of the menstrual cycle, normally a layer of endometriosis lining on the inside of the uterus is expelled, known as menstruation blood, instead some of the endometriosis tissues grow somewhere in the body to cause endometriosis. Endometriosis also react to hormone signals of the monthly menstrual cycle, by building and breaking up tissues and eliminating them through menstrual period.

        The Good, The Bad and The Side Effects of The Pill


The Pill normally is prescribed by your doctor to reduce the heavy period blood for woman with or with out endometriosis as well as in treating of period pain, or contraceptive purpose ( 21 days on and 7 days off).

A. The Good(Effectiveness)
1. Reduce the period blood flow(1) as resulting in lowering the risk of more developing of endometriosis(2).
2. Reduce the bleeding(1) by thinning the endometrial lining.
3. Reduce the period pain(3) by inhibiting the hormone prostaglandins hormones that cause the uterine muscles spasm(2).
4. Shrink the endometriosis and reduce the bleeding of into cysts and pelvic cavity(3) because the Pill creates the pregnant-like state.
5. Suppress the estrogen that is needed to start a menstrual cycle(5)(6).

B. The Bad(The Risks)
1. Blood clots
All hormonal methods of birth control pose a threat to normal blood flow. The oral contraceptive combination pill is no exception, it increases the risk of blood clots in your legs or on the lung caused by estrogen in the pill that makes your blood thicker in the veins(7)(8).

2. Stroke(9)(10)
Woman who takes the oral contraceptive combination pill increases the risk of stroke caused by blockage of blood flow to the brain as resulting of high level of estrogen in the pill that reduces the oxygen transportation as the blood getting thicker.

3. Heart disease(11)
Similar to the stroke, as our blood get thicker, our heart has to pump harder to provide oxygen for our body cells need causing hypertension. If our heart has to work that hard for a prolong period of time because of long term use of birth control pill, it will be damaged causing heart disease.

4. Skin pigment(12)(13)
Some woman may experience increasing of pigmentation of skin that shows up in patchy and light brown area caused by estrogen in the pill.

5. Mood swing(14)
Some women may experience mood swing while taking the pill, it is caused by significant changes in your hormone levels affecting the chemicals that regulate mood such as level of estrogen and progesterone in the pill.

6. Infertility(15)(16)
Some women after coming off the birth control pill and hope to get pregnant, they may be disappointed. Not only the effects of birth control pill maybe needed sometime to wire off, our body may never be able to adjust causing lost of period permanently and induced risk ovarian cancer.

7. Increase the risk of fibroids but decreased with duration of oral contraceptiveuse(17)
Oral contraceptive combination pill contains estrogen that promote the growth of fibroids. If you have fibroids and you want take the oral contraceptive pill, you should talk to your doctor first.

C. The Side effects
1. Bleeding and spotting(18)
Bleeding and spotting is normal for the first six months for women starting any oral contraceptive combination pill because our body needs time to adjust to the new medication.

2. Lost interest in sex
Women who take the contraceptive pill are in danger of permanently lost their interest in sex because the oral contraceptive pill inhibits testosterone, the hormone that drives sexual desire even after if they stop the pill(19).

3. Chloasma or melisma(12)(13)
It caused by hormonal changes, as in pregnancy and intake of estrogen in the oral contraceptive pill.

4. Nutritional deficiency(20)(21)
Oral contraceptive pill causes vitamin and mineral imbalances or deficiencies. It depletes magnesium for healthy heart, coenzyme Q10 for healthy heart muscles, folic acid for preventing cervical abnormalities, vitamin B6, B2, B3, zinc, etc.

5. Alternation of emotion in facial expression
The pill may alter the detection of emotions in facial expressions, according to the study by 1Institute of Psychology, Clinical Psychology Department, Leiden University(4).

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References
(1) Satisfaction and health-related quality of life in women with heavy menstrual bleeding; results from a non-interventional trial of the levonorgestrel-releasing intrauterine system or conventional medical therapy by Xu L1, Lee BS2, Asif S3, Kraemer P4, Inki P5.(PubMed)
(2) Combined oral contraceptives: health benefits beyond contraception by Caserta D1, Ralli E, Matteucci E, Bordi G, Mallozzi M, Moscarini M.(PubMed)
(3) Low-dose oral contraceptive pill for dysmenorrhea associated withendometriosis: a placebo-controlled, double-blind, randomized trial by Harada T1, Momoeda M, Taketani Y, Hoshiai H, Terakawa N.(PubMed)
(4) Oral contraceptives may alter the detection of emotions in facial expressions by Hamstra DA1, De Rover M2, De Rijk RH3, Van der Does W4.(PubMed)
(5) Menstrual suppression for adolescents by Altshuler AL1, Hillard PJ.(PubMed)
(6) Menstrual suppression: current perspectives by Hillard PA.(PubMed)
(7) Debating the evidence: oral contraceptives containing drospirenone and risk ofblood clots by Dodd S.(PubMed)
(8) Risk of venous thromboembolism from use of oral contraceptives containing different progestogens and oestrogen doses: Danish cohort study, 2001-9 by Lidegaard Ø1, Nielsen LH, Skovlund CW, Skjeldestad FE, Løkkegaard E.(PubMed)
(9) Risk of ischemic stroke among users of the oral contraceptive pill: The Melbourne Risk Factor Study (MERFS) Group by Siritho S1, Thrift AG, McNeil JJ, You RX, Davis SM, Donnan GA; Melbourne Risk Factor Study (MERFS) Group.(PubMed)
(10) Use of low-dose oral contraceptives and stroke in young women by Schwartz SM1, Siscovick DS, Longstreth WT Jr, Psaty BM, Beverly RK, Raghunathan TE, Lin D, Koepsell TD.(PubMed)
(11) Prospective measurement of blood pressure and heart rate over 24 h in women using combined oral contraceptives with estradiol by Grandi G1, Xholli A1, Napolitano A1, Piacenti I1, Bellafronte M1, Cagnacci A2.(PubMed)(12). [Dermal changes in response to hormonal contraceptives (author's transl)].[Article in German]by Scholz C, Donat H.(PubMed)
(13) Melasma and other skin manifestations or oral contraceptives by Resnik SS.(PubMed)
(14) Comparison of scales for evaluating premenstrual symptoms in women usingoral contraceptives by Coffee AL1, Kuehl TJ, Sulak PJ.(PubMed)
(15) Association of oral contraceptive use, other contraceptive methods, andinfertility with ovarian cancer risk by Tworoger SS1, Fairfield KM, Colditz GA, Rosner BA, Hankinson SE.(PubMed)
(16) Primary infertility and oral contraceptive steroid use by Bagwell MA1, Thompson SJ, Addy CL, Coker AL, Baker ER.(PubMed)
(17) Use of oral contraceptives and uterine fibroids: results from a case-control study by Chiaffarino F1, Parazzini F, La Vecchia C, Marsico S, Surace M, Ricci E.(PubMed)
(18) Efficacy and safety of an ascending-dose, extended-regimen levonorgestrel/ethinyl estradiol combined oral contraceptive by Portman DJ1, Kaunitz AM2, Howard B3, Weiss H4, Hsieh J5, Ricciotti N6.(PubMed)
(19) Hormonal contraception and mental health: results of a population-based study by Toffol E1, Heikinheimo O, Koponen P, Luoto R, Partonen T.(PubMed)
(20) Biological variability and impact of oral contraceptives on vitamins B(6), B(12) and folate status in women of reproductive age by McArthur JO1, Tang H, Petocz P, Samman S.(PubMed)
(21) Oral contraceptives and changes in nutritional requirements by Palmery M1, Saraceno A, Vaiarelli A, Carlomagno G.(PubMed)

Monday, August 22, 2016

Women Health: Endometriosis: The Effects of Vitamin K

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                          Endometriosis

During the last stage of the menstrual cycle, normally a layer of endometriosis lining on the inside of the uterus is expelled, known as menstruation blood, instead some of the endometriosis tissues grow somewhere in the body to cause endometriosis. Endometriosis also react to hormone signals of the monthly menstrual cycle, by building and breaking up tissues and eliminating them through menstrual period.

                The health effects of Vitamin K



Vitamin K was first discovered by Danish scientist Herrik Dam in 1929. It is a fat-soluble vitamin. It is best known for its ability of protein synthesis and blood coagulation. Dietary deficiency is extremely rare because it is produced by bacteria in the digestive system. Since it is fat soluble, it can be stored in our body and we do no need to take them regularly.

1. Nervous(1)(4) and circulation systems
Vitamin K activated protein Gas6 which has been shown to be actively involved in cell survival, chemotaxis, mitogenesis, and cell growth of neurons and glial cells(1). It also helps to convert glucose into glycogen(2) which is essential for improving the liver function in fighting against the forming of bad cholesterol accumulated(3) in the blood stream causing high blood pressure(3), making transportation of oxygen more difficult to the body's cell, increasing the risk of heart disease(4) and elevating tensions of nervous system. Glycogen can be stored in the liver, muscles, and can be used in case of deficiency.

2. Abnormal bleeding(5)(6) and menstrual Pain(7)
Vitamin K also helps in production of prothrombin which is an important substance for blood clotting. Women with endometriosis were found to have vitamin K deficiency leading to menstrual pain and heavier than normal bleeding during menstruation.

3. Immune system
Since vitamin K helps to strengthen the liver's function(8)(9), indirectly it protects our body from environmental toxins and free radical invasion that may cause abnormal endometrial implants(9) and adhesion growing(9) somewhere else other than the endometrium as we mentioned in the other articles.

4. Cell Growth(10)(11)(12)
Vitamin K is also said to be an important vitamin that helps to regulate the cellular functions including cell adhesion, cell proliferation, and protection against the cell's cytoskeleton to break up the membrane and bulge outward causing the loss of membrane asymmetry and attachment. Deficiency of vitamin K may cause an increase in the risk of irregularity cellular growth, such as endometriosis.

5. Anemia(5)(6)(13)
Since vitamin K deficiency causes heavy bleeding for women with endometriosis adhered to the abdominal region leading to anemia as a result of depletion of red blood cells in the body or inability of the body to produce more red blood cell to cover the loss during menstruation


Fibroids Miracle(TM)
Show You How To Permanently Eliminate
All Types of Uterine Fibroids Within 2 Month


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The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet


Ovarian Cysts And PCOS Elimination

Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods LibraryEat Yourself Healthy With The Best of the Best Nature Has to Offer

 
References
(1) Vitamin K and the nervous system: an overview of its actions by Ferland G.(PubMed)
(2) Possible effects of one week vitamin K (menaquinone-4) tablets intake onglucose tolerance in healthy young male volunteers with different descarboxy prothrombin levels by Sakamoto N1, Nishiike T, Iguchi H, Sakamoto K.(PubMed)
(3) Correlation of vitamin K-dependent clotting factors with cholesterol and triglycerides in healthy young adults by Hoffman CJ1, Lawson WE, Miller RH, Hultin MB.(PubMed)
(4) [Frequency of use of oral vitamin K antagonists in patients with atrial fibrillation and cognitive function disturbances].[Article in Polish] by Gorzelak P, Zyzak S, Krewko Ł, Mozdzan M, Broncel M.(PubMed)
(5) Oral anticoagulation and vitamin K deficiency by Eichinger S.(PubMed)
)6) "Haemorrhagic disease of the newborn" 89 years later than expected: vitamin K deficiency bleeding by Seguna R1, Maw KZ2, Lyall HD2, Bowles KM3.(PübMed)
(7)Vitamin K acupuncture pint injection for severe primary dysmenorrhea: an international pilot study by Wang L1, Cardini F, Zhao W, Regalia AL, Wade C, Forcella E, Yu J.(PubMed)
(8)Procoagulant therapeutics in liver disease: a critique and clinical rationale by Shah NL, Intagliata NM, Northup PG, Argo CK, Caldwell SH.(PubMed)
(9) The potent antioxidant activity of the vitamin K cycle in microsomal lipid peroxidation by Vervoort LM1, Ronden JE, Thijssen HH.(PubMed)
(10) Vitamin K enhancement of sorafenib-mediated HCC cell growth inhibition in vitro and in vivo by Wei G1, Wang M, Hyslop T, Wang Z, Carr BI.(PubMed)
(11) Sorafenib combined vitamin K induces apoptosis in human pancreatic cancercell lines through RAF/MEK/ERK and c-Jun NH2-terminal kinase pathways by Wei G1, Wang M, Carr BI.(PubMed)
(12) Vitamin K3 disrupts the microtubule networks by binding to tubulin: a novel mechanism of its antiproliferative activity by Acharya BR1, Choudhury D, Das A, Chakrabarti G.(PubMed)
(13) Surgical evacuation of neonatal intracranial hemorrhage due to vitamin K deficiency bleeding.by Zidan AS1, Abdel-Hady H.(PubMed)

Sunday, August 21, 2016

Women Health: Endometriosis: The Effects of Vitamin E

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                          Endometriosis

During the last stage of the menstrual cycle, normally a layer of endometriosis lining on the inside of the uterus is expelled, known as menstruation blood, instead some of the endometriosis tissues grow somewhere in the body to cause endometriosis. Endometriosis also react to hormone signals of the monthly menstrual cycle, by building and breaking up tissues and eliminating them through menstrual period.

                The health effects of Vitamin E


Vitamin E, best known for its powerful antioxidant property is a fat soluble vitamin and can be stored in our body. We don't require to take it regularly.

1. Immune system(1)(2)
Since vitamin E is an antioxidant, it helps to increase liver function in fighting the forming of free radicals(4), abnormal cells and cancers(3). In endometriosis, it prevents the growth of abnormal endometrial cells to form implants and adhesion in other parts of the body excluding the endometrium.

2. Cell protection(5)(6)
Since vitamin E protects the fatty acid against degradation in the human body(2) that helps to prevent against the oxidation in cell membranes and cellular regions resulting in protecting against the breaking off of the capillary wall causing heavy blood flow(7) during menstruation.

3. Red blood cells(9)
Deficiency of vitamin E in women with endometriosis were also found to have anemia(10). It is caused by the faster than normal aging of red blood cells because of oxidative destruction of red blood cells(8).

4. Nervous system(11)
Since we already known that vitamin E is essential for increasing the ability of red blood cells to carry oxygen in the circulation system, it helps to nourish the brain cells fighting against symptoms of endometriosis such as mood swings, anxiety, and depression.

5. Hormone imbalance
Deficiency of vitamin E also interferes with normal functions of thyroid(12)(13) and pituitary(14) glands causing the decrease of levels of fatty acids resulting in endometrial menstrual cramps(15) which in turn result in the over-production of certain prostaglandins hormones.
 
References
(1) Immunomodulatory effects of selenium and vitamin E on alterations in T lymphocyte subsets induced by T-2 toxin by Salimian J1, Arefpour MA, Riazipour M, Poursasan N.(PubMed)
(2) The ratio of dietary (n-6) to (n-3) fatty acids influences immune systemfunction, eicosanoid metabolism, lipid peroxidation and vitamin E status in aged dogs. Wander RC1, Hall JA, Gradin JL, Du SH, Jewell DE.(PubMed)
(3) Selenium and Vitamin E Cancer Prevention Trial: a nutrient approach to prostate cancer prevention by Dunn BK1, Ryan A, Ford LG.(PubMed)
(4) Oxygen free radicals and hypercholesterolemic atherosclerosis: effect ofvitamin E by Prasad K1, Kalra J.(PubMed)
(5) Vitamin E-enhanced IL-2 production in old mice: naive but not memory T cells show increased cell division cycling and IL-2-producing capacity by Adolfsson O1, Huber BT, Meydani SN.(PubMed)
(6) Vitamin E protection against chemical-induced cell injury. I. Maintenance of cellular protein thiols as a cytoprotective mechanism by Pascoe GA, Olafsdottir K, Reed DJ.(PubMed)
(7) Symptomatic vitamin E deficiency diagnosed after histological recognition of myometrial lipofuscinosis by Evans DJ1, Berney DM, Pollock DJ.(PubMed)
(8) Effect of linezolid on hematological and oxidative parameters in rats by Wang T, Guo D, Dong X, Mu L.(PubMed)
(9) Red cell metabolism in iron deficiency anemia. 3. The relationship between glutathione peroxidase, catalase, serum vitamin E, and susceptibility of iron-deficient red cells to oxidative hemolysis by Macdougall LG.(PubMed)
(10) Effects of erythropoietin and vitamin E-modified membrane on plasmaoxidative stress markers and anemia of hemodialyzed patients by Usberti M1, Gerardi G, Bufano G, Tira P, Micheli A, Albertini A, Floridi A, Di Lorenzo D, Galli F.(PubMed)
(11) Tocotrienol: the natural vitamin E to defend the nervous system? by Sen CK1, Khanna S, Roy S.(PubMed)
(12) Nitrite-induced alterations in sex steroids and thyroid hormones of Labeo rohita juveniles: effects of dietary vitamin E and L-tryptophan.by A1, Sahu NP, Pal AK, Akhtar MS.(PubMed)
(13) [Effect of vitamin E on general metabolism and on thyroid function in subjects with normal and altered basal metabolism].[Article in Undetermined Language] by JACONO G, D'ALESSANDRO B.(PubMed)
(14) Electron microscopic studies of anterior pituitary glands of vitamin E-deficient male mice by I Ichihara(PubMed)
(15) Menstrual pain in Danish women correlated with low n-3 polyunsaturated fatty acid intake by Deutch B.(http://www.ncbi.nlm.nih.gov/pubmed/7588501PubMed)

Saturday, August 20, 2016

Women Health: Endometriosis - The health effects of Vitamin C

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                          Endometriosis

During the last stage of the menstrual cycle, normally a layer of endometriosis lining on the inside of the uterus is expelled, known as menstruation blood, instead some of the endometriosis tissues grow somewhere in the body to cause endometriosis. Endometriosis also react to hormone signals of the monthly menstrual cycle, by building and breaking up tissues and eliminating them through menstrual period.


The health effects of Vitamin C


Vitamin C, also known as L-ascorbate is a water soluble vitamin with a chemical structure formula of C6H6O6 and cannot be stored in the body for more than 24 hours. We are required to take it regularly. It is also best known for it's antioxidant property in strengthening the immune system.

1. Immune system(1)
Vitamin C plays an important role in strengthening the immune system because of it's powerful antioxidant property(2). It helps to guard our body against the forming of free radicals(3) and abnormal growth of endometrial cells in other parts of the body.

2. Increase absorption of digestive system
Most women with endometriosis are found to have deficiency of some kinds of vitamins and minerals such as vitamin B complex, folic acid, zinc, and magnesium. Increasing intake of vitamin C not only helps to improve digestive absorption(6)(7), but also increases the body's function in fighting against all kinds of diseases(8) including endometriosis.

3. Endometrial related pain
Besides helping strengthen the liver function to balance the estrogen level(5) during menstrual cycle, vitamin C also balances the level of prostaglandins hormones in the prostaglandins family resulting in the calming of over-active uterine muscles(4).

4. Reduce heavy blood flow and blood clotting(10)
Vitamin C not only helps to protect the breaking off of the capillaries that cause heavy blood flow(11) for women with endometriosis during menstruation but also prevents blood clotting(9) caused by reduction of prothrombin, thrombin, and thrombokinase concentrations in the body.

5. Decrease infection and inflammation
Vitamin C helps in protein metabolism. It not only provides our body with certain necessary proteins but also blocks the synthesis of vital proteins that cause infection(14)(15) and inflammation(8)(12)(13).

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References
(1)[Vitamin C and its physiological role with respect to the components of theimmune system][Article in Czech] by Holmannová D1, Koláčková M, Krejsek J.(PubMed)
(2) Vitamin C. Give a boost to your immune system by Webb R.(PubMed)
(3) Antioxidants, inflammation and cardiovascular disease by Mangge H, Becker K, Fuchs D, Gostner JM.(PubMed)
(4) Antioxidant supplementation reduces endometriosis-related pelvic pain in humans by Santanam N1, Kavtaradze N, Murphy A, Dominguez C, Parthasarathy S.(PubMed)
(5) Vitamin E, Vitamin C, or Losartan Is Not Nephroprotectant against Cisplatin-Induced Nephrotoxicity in Presence of Estrogen in Ovariectomized Rat Model by Nematbakhsh M1, Pezeshki Z, Eshraghi-Jazi F, Ashrafi F, Nasri H, Talebi A, Safari T, Haghighi M, Mansouri A.(PubMed)
(6) [Diminution of digestive absorption of vitamin C in the course of cirrhosis].[Article in French] by WARTER J, SCHIRARDIN H, METAIS P.(PubMed)
(7) [Vitamin C treatment of digestive disorders from intolerance to PASabsorption].[Article in Undetermined Language] by PICHAT.(PubMed)
(8)Vitamin C as an antioxidant: evaluation of its role in disease prevention. by Padayatty SJ1, Katz A, Wang Y, Eck P, Kwon O, Lee JH, Chen S, Corpe C, Dutta A, Dutta SK, Levine M.(PubMed)
(9) Impaired capacity for acute endogenous fibrinolysis in smokers is restored byascorbic acidby Kaehler J1, Koeke K, Karstens M, Schneppenheim R, Meinertz T, Heitzer T.(PubMed)
(10) [The significance of changes in the functional properties of blood platelets, factor XIII activity and fibrin clot quality in the pathogenesis of hemorrhagic diathesis secondary to experimental vitamin C deficiency].[Article in Russian] by Sushkevich GN, Khnychev SS, Oĭvin VI.(PubMed)
(11) Functional menorrhagia: treatment with bioflavonoids and vitamin C by COHEN JD, RUBIN HW.(PubMed)
(12) Effect of high-dose intravenous vitamin C on inflammation in cancer patients by Mikirova N1, Casciari J, Rogers A, Taylor P.(PubMed)
(13) Vitamin C further improves the protective effect of glucagon-like peptide-1 on acute hypoglycemia-induced oxidative stress, inflammation, and endothelial dysfunction in type 1 diabetes by Ceriello A1, Novials A, Ortega E, Canivell S, La Sala L, Pujadas G, Bucciarelli L, Rondinelli M, Genovese S.(PubMed)
(14) Effects of high dose vitamin C treatment on Helicobacter pylori infection and total vitamin C concentration in gastric juice by Jarosz M1, Dzieniszewski J, Dabrowska-Ufniarz E, Wartanowicz M, Ziemlanski S, Reed PI.(PubMed)
(15) Vitamin C Is an Essential Factor on the Anti-viral Immune Responses through the Production of Interferon-α/β at the Initial Stage of Influenza A Virus (H3N2)Infection by Kim Y1, Kim H, Bae S, Choi J, Lim SY, Lee N, Kong JM, Hwang YI, Kang JS, Lee WJ.(PubMed)