Posted by Chantel M. Contributed by US National
Library of Medicine National Institutes of Health
In the study to investigate whether phytoestrogen intake is associated with reduced breast cancer risk, using a novel phytoestrogen database, posted in PubMed, researchers found that lignan intake was associated with a reduced breast cancer
risk (Q5 vs. Q1 MVOR: 0.81, 95% CI: 0.65, 0.99); however, following
stratification by BMI, this reduction in risk was statistically
significant only among overweight (BMI > 25) women. Total
phytoestrogen intake was also associated with a risk reduction among
overweight women only. Among pre-menopausal women, total phytoestrogen
intake was associated with a significant reduction in breast cancer
risk among overweight women only (Q5 vs. Q1 MVOR: 0.51, 95% CI: 0.30,
0.87). Among post-menopausal women, no statistically significant
association was observed between breast cancer risk and isoflavones or lignans.
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