Synaptodendritic recovery following HIV-1 Tat exposure: Neurorestoration by phytoestrogens

Posted by Chantel Martiromo. research contributed by PubMed
 
In the study to examine the integrity of the dendritic network after exposure to HIV-1 Tat by labeling filamentous actin (F-actin)-rich structures (puncta) in primary neuronal cultures, posted in PubMed, showed that after 24 hours of treatment, HIV-1 Tat was associated with the dendritic arbor and produced a significant reduction of F-actin-labeled dendritic puncta as well as loss of dendrites. Pretreatment with either of two plant-derived phytoestrogen compounds (daidzein and liquiritigenin), significantly reduced synaptodendritic damage following HIV-1 Tat treatment. Additionally, 6 days after HIV-1 Tat treatment, treatment with either daidzein or liquiritigenin enhanced recovery, via the estrogen receptor, from HIV-1 Tat-induced synaptodendritic damage. These results suggest that either liquiritigenin or daidzein may not only attenuate acute synaptodendritic injury in HIV-1, but also promote recovery from synaptodendritic damage. This article is protected by copyright. All rights reserved.

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