Altered adipocyte function in polycystic ovary syndrome

Posted by Chantel Martiromo, research contributed by PubMed

Adipocytokines are produced by adipose tissue and have been thought to be related to insulin resistance and other health consequences. In the study of fifty-two women with PCOS and 45 normal ovulatory women who were age- and weight-matched,  blood was obtained for adipocytokines (leptin, adiponectin, and resistin) as well as hormonal parameters and markers of insulin resistance as assessed by the quantitative insulin-sensitivity check index. Body mass index (BMI) was stratified into obese, overweight, and normal subgroups for comparisons between PCOS and controls, posted in PubMed, showed that when matched for BMI status, decreased adiponectin in PCOS represent the most marked change. This alteration may be the result of altered adipose tissue distribution and function in PCOS but no correlation with insulin resistance was found.

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