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Sunday, November 15, 2015

The Holistic Clinical Trials and Studiesof Polycystic Ovarian Syndrome: The fertility Herb Chaste tree berry

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                    Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).


  The prevention and management In Herbal Medicine

Polycystic ovary syndrome (PCOS) is unpreventable in Western medicine. Early diagnosis and treatment may reduce risk of its complications, including infertility, metabolic syndrome, obesity, diabetes, cardiovascular diseases, stroke, etc.

Reduce fat intake less than 30% of total calories with a low proportion of saturated fat and high in fiber from predominantly low-glycaemic-index-carbohydrate foods for patients with PCOs(827a). Calorie intake should be distributed between several meals per day with restricted intake of snacks and drinks(827)(828).

                   The fertility herb: Chaste tree berry

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in tonifying female reproductive systems(869), including premenstrual problems(865) and menopause symtoms(866)(867)(868)(869). There was report that reports chaste tree berry stems and leaves used by women as bedding "to cool the heat of lust" during the time of the Thesmophoria(870),

1. Androstenedione
Chaste berry tree contains androstenedione which is the common precursor of female sex hormone by converting to testosterone and the estrogens. through the enzyme aromatase(871) by acting as a as a weak partial agonist(872) of the androgen receptor to reduce risk of hormone imbalance that causes infertility. Unfortunately, Epidemioligical evidences suugested that androstenedione may contribute to the worsening of PCOS features as women with PCOs are found to associate to high concentration of androstenedione(873)(874)(875).

2. Epitestosterone
Epitestosterone is an inactive epimer of the hormone testosterone which has been used to enhance athletic performance for some athelic during competition(876)(877). The phytochemical is also found to to improve sexual development(878), sexual desire and sexual arousal(879) induced fertility.

3. Hydroxyprogesterone and progesterone
Chaste tree contains plant hydroxyprogesterone which is a steroid hormone produced during the synthesis of glucocorticoids and sex steroids(880), including the corticosteroids and the androgens and the estrogens(881). The phytochemical also raises the levels of progesterone if it is loo low and reduces it when it is too high in the women body(882), induced fertility.

4. Iridoid
The herb also contaaining iridoid as a intermediator of the biosynthesis of alkaloids improves the immune system in fighting against inflammation(883) and lessens the risks of immune system abnormal function in production of antibody against sperm invasion(884).

5. Glycoside
Glycoside is a flavonoid acted as an antioxidant in increasing the immune system in fighting against forming of free radical as well as guarding our body against irregular cell browth infection and inflammation(885)(886), and reducing the risk of abnormal function of immune system in production of antibody against sperm invasion(884).

Side effects
According to Drug.com the most common side effects of taking chaste berry tree include
Acne; cramping; diarrhea; hair loss; headache; increased menstrual flow; stomach pain; tiredness, etc....(887)

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months 


Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

References
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(870) Chaste tree(Happyherbcompany)
(871) Devlin, edited by Thomas M. (2010). Textbook of biochemistry : with clinical correlations (7th ed. ed.). Hoboken, NJ: John Wiley & Sons. p. 432.ISBN 0470281731.

(872) "Partial agonist/antagonist properties of androstenedione and 4-androsten-3β,17β-diol" published on The Journal of Steroid Biochemistry and Molecular Biology. Volume 91, Issues 4–5, August 2004, Pages 247–257
(873) Effects of androstenedione, insulin and luteinizing hormone on steroidogenesis in human granulosa luteal cells by S. Greisen, T. Ledet3 andP. Ovesen(Oxford Journal)
(874) Elevated serum androstenedione is associated with a more severe phenotype in women with polycystic ovary syndrome (PCOS) by Georgopoulos NA1, Papadakis E2, Armeni AK1, Katsikis I2, Roupas ND1, Panidis D2.(PubMed)
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(879) The Relation of Plasma Androgen Levels to Sexual Behaviors and Attitudes of Women1. by Persky, Harold PhD; Dreisbach, Lorraine MS; Miller, William R. PhD; O'Brien, Charles P. MD, PhD; Khan, Miftah A. MSc; Lief, Harold I. MD; Charney, Natalie; Strauss, Dorothy PhD(The Journal of biobehavior medicine)
(880) Human 17 - Hydroxyprogesterone, 17 - OHP ELISA kit Catalog No.E0454h
(881) 17 - Hydroxyprogesterone(Wikepieda)
(882) Agonistic and antagonistic properties of progesterone metabolites at the human mineralocorticoid receptor by Quinkler M1, Meyer B, Bumke-Vogt C, Grossmann C, Gruber U, Oelkers W, Diederich S, Bahr V.(PubMed)
(883) In vitro and in vivo immunomodulatory activities of iridoids fraction from Barleria prionitis Linn by Ghule BV1, Yeole PG.(PubMed)
(884) [Specific mucosal immunity in the female reproductive tract: protection against infectious diseases and regulation of fertility (part 2)].[Article in Czech] by Zivný J1, Sterzl I.(PubMed)
(885) New chalcanonol glycoside from the seeds of saw palmetto: antiproliferative and antioxidant effects by Abdel Bar FM1.(PubMed)
(886) Antioxidant properties, radical scavenging activity and biomolecule protection capacity of flavonoid naringenin and its glycoside naringin: a comparative study by Cavia-Saiz M1, Busto MD, Pilar-Izquierdo MC, Ortega N, Perez-Mateos M, Muñiz P.(PubMed)
(887) chaste tree(Drug.com, know more, be sure)

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