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Get Pregnant Naturally
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Thursday, December 31, 2015

The Holistic Clinical Trials and Studies of Polycystic Ovarian Syndrome: TCM food suggestions for Kidney Yin deficiency - Navy bean

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                    Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).

                    In Traditional Chinese Medicine Perspective
                               
While conventional medicine focus of using synthetic medication to induce ovulation and assisted artificial insemination for infertility couple, if the medicine fail, traditional Chinese medicine views polycystic ovarian syndrome in different approaches.Polycystic ovary syndrome, according to traditional Chinese medicine is a medical condition characterized by accumulative of fluid over a prolonged period of time causes of dampness and phlegms(247a)(247b) build up on the ovaries due to the effects of vary differentiations, affecting not only the women’s menstrual cycle, but also ovulation and fertility(1247a)(247b).

Dietary Suggestion, Life Style Modification and Nutritional Supplements according to TCM
According to Angela Warburton(1249), a doctor of Traditional Chinese Medicine practicing in Toronto, Canada, incorporating the proper dietary and lifestyle modifications, may make a BIG difference in the long-term for treatment of PCOs(1249).




PCOs Treatment according traditional Chinese medicine

Depending to differentiation, most common diagnosis of polycystic ovary syndrome can be classified into



Kidney yin deficiency

Along with common symptoms mentioned above, women with PCOs diagnosed with kidney yin deficiency may also experience yin vacuity induced cold expressive syndrome, including soreness of waist and knees(1848), lassitude(1848) and fatigue(1848), short breath(1848), poor appetite(1848), aversion to cold(184), cold extremities(1848), ringing in the ears(1850), migraine(1849), hearing problems(1850), a dry mouth and throat(1851), pale fingernails(1851), tidal fever(1851)and night sweating(1851), soles(1851) and chest(1851), constipation(1852),,......... as the kidneys no longer perform their functions of regulating fluid in moistening and nourishing organs and tissues of the body. According to TCM, too much cold/raw foods can aggravate the condition.

In the review of the Data base provided by PubMed, kidney yin deficiency may induce functional impairment or metabolic derangements in vital organs/tissues(1853) persuaded a conglomeration of sundry chronic disease state(1853), cognitive dysfunction(1854), vasomotor symptoms(1855),..... leading to accumulation of fluid in the body organ, promoted accentuation of inflammatory development of phlegm.
Kidney yin deficiency has shown to alter amino acid metabolism(1856), energy metabolism(1856) and gut microflora(1856), anovulatory infertility(1857) and
hypertension(1858), hyperinsulinemia(1859) and hyperandrogenia(1859)..... of which related to symptoms of PCOs(1859).


Foods for Kidney yin deficiency


List of foods suggested by TCM doctors for management and treatment of PCOs' women diagnosed with kidney yin deficiency, including

1. Navy bean
(See nutritional supplement suggested by TCM)
[Navy bean (White kidney bean)extract
The small, white kidney bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to their numerous health benefits(1402).

Nutritional ingredients
1. Carbohydrate
2. Protein
3. Dietary fiber
4. Vitamin A
5. Vitamin B1
6. copper
7. Iron
8. Manganese
9. Phosphorus
10. Magnesium(1402)
11. Catechin derivatives(1403)

12. Proanthocyanidins(1403)
13. Catechin glucoside(1403)
14. Etc.

Epidemiological studies, linking navy bean as a functional health foods, may be due to its phenolic composition in reduced the incidence of several chronic diseases(1402)(1411) that shared an inflammatory component(1403), including irregular cell growth(1406)(1407), diabetes(1402)(1407), CVD(1407), glycemic response(1404)(1405)(1407), aid digestion(1404)(1405), sleep disorder(1402), irritable bowel syndrome(1402) and constipation(1402), infertility(1402), neurotransmitter dysfunction(1402), colitis(1408), improved colon health(1408)(1409). etc. probably through its total phenolic content effects on antioxidant(1410)(1411) and anti inflammatory activities(1411) and other mechanism.

According to studies, white kidney bean also processes certain properties against PCOs related syndrome including effect on diabesity, a collection of obesity/overweight, type 2 diabetes mellitus and insulin resistance(1412), GI index(1413) through its carb blockers(1413) mimiced the beneficial effects of fibers(1412). Its extract, according to studies, also induced blood glucose levels(1415) and weight loss(1414)(1415) through blocking carbohydrate absorption(1414), and regulating hoglycaemic and anorexigenic activities of an alpha-amylase inhibitor(1415)].

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca p/general-health.html

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
References

(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women WithPolycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(1246) [Clinical study of area of Jiangsu province of polycystic ovarian syndrome correlation distribution of traditional Chinese medicine syndrome type and improper diet]. [Article in Chinese] by Feng Y, Gao YP.(PubMed)
(1247) [Preliminary study on relationship of disease-syndrome-symptom of ovulatory disorder infertility based on factor analysis]. [Article in Chinese] by Li M, Ma K, Shan, J.(PubMed)
(1247a) A Comprehensive Treatment of Polycystic Ovarian Syndrome (PCOS) by Liqin Zhao(1848) ontrolled trail on moxibustion for maintenance hemodialysis patients in deficiency syndrome]. [Article in Chinese] Li N1, Qiu MY, Hao JR, Zhang QM, Wang SH, Liang F, Yin Y, Luan J, Ge GZ, Qin T, Li BQ.(PubMed)
(1849) [Observation on therapeutic effect of the new Bianshi (stone needle) therapy on migraine]. [Article in Chinese] Yin ZJ1, Yan YJ, Bao HL(PubMed)
(1850) [Study on relation of kidney-deficiency with hearing damage and serum trace elements in patients with chronic nephropathy]. [Article in Chinese] by Yu J1, Xu Y, Fu XD.(PubMed)
(1851) [A family survey of syndromes of traditional Chinese medicine in patients with beta-thalassemia]. [Article in Chinese] by Wang WJ1, Wu ZK, Zhang XH, Liu WJ, Liu YM, Fang SP, Wang RX, Zhang C, Li PP, Luo RG.(PubMed)
(1852) The clinical experiences of Dr. CAI Gan in treating chronic constipation by Zhang ZL1, Zhu MP, Liu Q, Lei YX.(PubMed)
(1853) [Analysis of 35 cases of pathology in yin deficiency syndrome]. [Article in Chinese] by Dai HL, Chen ZL, Song QL.(PubMed)
(1854) Liuwei Dihuang decoction facilitates the induction of long-term potentiation (LTP) in senescence accelerated mouse/prone 8 (SAMP8) hippocampal slices by inhibiting voltage-dependent calcium channels (VDCCs) and promoting N-methyl-d-aspartate receptor (NMDA) receptors by Huang Y1, Zhang H, Yang S, Qiao H, Zhou W, Zhang Y.(PubMed)
(1855) Diagnosis of symptomatic postmenopausal women by traditional Chinese medicine practitioners by Zell B1, Hirata J, Marcus A, Ettinger B, Pressman A, Ettinger KM.(PubMed)
(1856) An integrated metabonomic and proteomic study on Kidney-Yin Deficiency Syndrome patients with diabetes mellitus in China by Jiang N1, Liu HF2, Li SD1, Zhou WX1, Zhang YX1, Zhang Q3, Yan XZ3.(PubMed)
(1857) [Preliminary study on relationship of disease-syndrome-symptom of ovulatory disorder infertility based on factor analysis]. [Article in Chinese] by Li M, Ma K, Shan J.(PubMed)
(1858) Traditional chinese medicine syndromes for essential hypertension: a literature analysis of 13,272 patients by Wang J1, Xiong X1, Liu W1.(PubMed)
(1859) [Clinical observation on treatment of hyperinsulinemia and hyperandrogenism anovulatory patient with replenishing kidney-yin drugs]. [Article in Chinese] by Zhou LR1, Yu J.(PubMed)

Wednesday, December 30, 2015

The Holistic Clinical Trials and Studies of Polycystic Ovarian Syndrome: TCM Herbal formulas for Kidney Yang deficiency

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                    Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).

                    In Traditional Chinese Medicine Perspective
                               
While conventional medicine focus of using synthetic medication to induce ovulation and assisted artificial insemination for infertility couple, if the medicine fail, traditional Chinese medicine views polycystic ovarian syndrome in different approaches.Polycystic ovary syndrome, according to traditional Chinese medicine is a medical condition characterized by accumulative of fluid over a prolonged period of time causes of dampness and phlegms(247a)(247b) build up on the ovaries due to the effects of vary differentiations, affecting not only the women’s menstrual cycle, but also ovulation and fertility(1247a)(247b).

Dietary Suggestion, Life Style Modification and Nutritional Supplements according to TCM
According to Angela Warburton(1249), a doctor of Traditional Chinese Medicine practicing in Toronto, Canada, incorporating the proper dietary and lifestyle modifications, may make a BIG difference in the long-term for treatment of PCOs(1249).




PCOs Treatment according traditional Chinese medicine

Depending to differentiation, most common diagnosis of polycystic ovary syndrome can be classified into

Kidney yang deficiency

Along with common symptoms mentioned above, women with PCOs diagnosed with kidney yang deficiency may also experience yang vacuity induced cold expressive syndrome, including
lumbago, cold limbs, fatigue, cold aversion, feverish sensation in chest, palms and soles(1573),
difficulty in urination, enuresis, incontinence, declining libido and edema(1574) as a result of kidneys no longer perform their function in store fluid to moister and warm the body for healthy function in the body's organs and tissues, inducing adrenal insufficient chronic lower back pain(1575)(1580), depression(1575), hypothyroidism(1579)(1575), nephritis(1578)(1575), ...(1575), leading to failure in transform damp heat expression, promoted accentuation of inflammatory development of phlegm(1583).
Kidney yang deficiency has shown to alter carbohydrate and lipid metabolisms (free fatty acids, 1-monolinoleoylglycerol, and cholesterol), gut microbiota metabolism (indole-3-propionic acid), indued anovulatory infertility( 1581) and hypertension(1582) of which related to symptoms of PCOs(1576)(1577).



Herbal formulas for kidney yang deficiency By TCM



The below formulas of traditional Chinese medicine for treatment kidney yang deficiency induced Polycystic ovary syndrome, contributed by "TREATMENT OF OVARIAN CYSTS WITH CHINESE HERBS" by Subhuti Dharmananda, Ph.D., Director, Institute for Traditional Medicine, Portland(1833). We recommend readers to read the complete article for more details at the link provided.
1. The formula one
rehmannia (shoudihuang andshengdihuang) 12 grams
aconite (fuzi) 6 grams
dioscorea (shanyao) 9 grams
epimedium (yinyanghuo) 9 grams
psoralea (buguzhi) 9 grams
cuscuta (tusizi) 9 grams
citrus (chenpi) 1.5 grams

Aconite, like cinnamon bark, helps restore warmth to the kidney; epimedium, psoralea, and cuscuta further enhance the kidney yang and produce warmth. Citrus is included here primarily to aid the digestion of the rich tonic herbs, mainly the rehmannia. These amounts are for a one day dosage; the herbs are decocted, dried, and made into tablets; the usual instruction is to take 5 tablets each time, three times daily. To treat polycystic ovaries (or bronchitis in which there is substantial phlegm accumulation), this formulation might be combined with a phlegm-resolving formula such as Tan Yin Wan (pill for phlegm accumulation). Tan Yin Wan contains the many of the same ingredients as Cinnamon and Rehmannia Combination, except that ma-huang and deer antler gelatin are replaced by atractylodes (cangzhu and baizhu), aconite, raphanus (laifuzi), and perilla fruit (zisuzi). This pill treats the combined syndrome of deficiency of spleen and kidney yang(1833).
2. The formula 2
According to the general doctrine of Chinese medicine, many diseases develop from an excess condition in the early stage to a deficiency syndrome in the later stage of its development. Thus, young women with polycystic ovaries may tend to have an excess syndrome (as described in the above evaluation, in which the average age of the patients was 24.6 years), and older women may tend to reveal the deficiency syndrome (with kidney yang depleted). However, due to genetic, behavioral, and environmental factors, some young women may already have a deficiency syndrome by the time the particular disease (in this case polycystic ovaries) has developed. Therefore age cannot be used as the sole factor in deciding among treatment strategies.
In a clinical trial by Dr. Yu Jin of the Shanghai Medical University Obstetrics and Gynecology Hospital, 133 patients with polycystic ovary syndrome were treated with the following base formula:
rehmannia (shoudihuang) 12 grams
dioscorea (shanyao) 12 grams
polygonatum (huangjing) 12 grams
epimedium (yinyanghuo) 12 grams
psoralea (buguzhi) 12 grams
gleditsia (zaojiaoci) 12 grams
fritillaria (chuanbeimu) 12 grams
pangolin scale (chuanshanjia) 9 grams

This formula was modified either for signs of cold (adding aconite and cinnamon bark) or for liver qi stagnation (adding moutan, gardenia, bupleurum, tang-kuei, and blue citrus, while removing gleditsia and fritillaria). According to Dr. Yu Jin, 82.7% of the women so treated ovulated and of 76 women that were known to be infertile, 36 became pregnant(1833).


Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to General health http://kylejnorton.blogspot.ca/


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca p/general-health.html


Super foods Library
, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women WithPolycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(1246) [Clinical study of area of Jiangsu province of polycystic ovarian syndrome correlation distribution of traditional Chinese medicine syndrome type and improper diet]. [Article in Chinese] by Feng Y, Gao YP.(PubMed)
(1247) [Preliminary study on relationship of disease-syndrome-symptom of ovulatory disorder infertility based on factor analysis]. [Article in Chinese] by Li M, Ma K, Shan, J.(PubMed)
(1247a) A Comprehensive Treatment of Polycystic Ovarian Syndrome (PCOS) by Liqin Zhao
References
(1833) "TREATMENT OF OVARIAN CYSTS WITH CHINESE HERBS" by Subhuti Dharmananda, Ph.D., Director, Institute for Traditional Medicine, Portland

Tuesday, December 29, 2015

The Holistic Clinical Trials and Studies of Polycystic Ovarian Syndrome: TCM Herbal Medicine for Kidney Yang deficiency - Wu Wei Zi

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                    Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).

                    In Traditional Chinese Medicine Perspective
                               
While conventional medicine focus of using synthetic medication to induce ovulation and assisted artificial insemination for infertility couple, if the medicine fail, traditional Chinese medicine views polycystic ovarian syndrome in different approaches.Polycystic ovary syndrome, according to traditional Chinese medicine is a medical condition characterized by accumulative of fluid over a prolonged period of time causes of dampness and phlegms(247a)(247b) build up on the ovaries due to the effects of vary differentiations, affecting not only the women’s menstrual cycle, but also ovulation and fertility(1247a)(247b).

Dietary Suggestion, Life Style Modification and Nutritional Supplements according to TCM
According to Angela Warburton(1249), a doctor of Traditional Chinese Medicine practicing in Toronto, Canada, incorporating the proper dietary and lifestyle modifications, may make a BIG difference in the long-term for treatment of PCOs(1249).




PCOs Treatment according traditional Chinese medicine

Depending to differentiation, most common diagnosis of polycystic ovary syndrome can be classified into

Kidney yang deficiency

Along with common symptoms mentioned above, women with PCOs diagnosed with kidney yang deficiency may also experience yang vacuity induced cold expressive syndrome, including
lumbago, cold limbs, fatigue, cold aversion, feverish sensation in chest, palms and soles(1573),
difficulty in urination, enuresis, incontinence, declining libido and edema(1574) as a result of kidneys no longer perform their function in store fluid to moister and warm the body for healthy function in the body's organs and tissues, inducing adrenal insufficient chronic lower back pain(1575)(1580), depression(1575), hypothyroidism(1579)(1575), nephritis(1578)(1575), ...(1575), leading to failure in transform damp heat expression, promoted accentuation of inflammatory development of phlegm(1583).
Kidney yang deficiency has shown to alter carbohydrate and lipid metabolisms (free fatty acids, 1-monolinoleoylglycerol, and cholesterol), gut microbiota metabolism (indole-3-propionic acid), indued anovulatory infertility( 1581) and hypertension(1582) of which related to symptoms of PCOs(1576)(1577).



Herbal medicine for kidney yang deficiency
6. Fructus Schisandrae (Wu Wei Zi)
(See stress management herbs in herbal medicine for more infomation)
[Schisandra also is known as Wu Wei Zi, a twining shrub living its life by climbing on other vegetation, belongings to the family Schisandraceae, native to Asia and North America, The warm, sweet, bitter, sour, acrid, salty herb has been used in tradional Chinese medicine as antioxidant(1218)(1219), anti stress(1220)(1221), anti microbial(1224)(1225)(1226) agent and to improve metabolism(1227)(1228), enhance central nervous system(1229)(1230)(1233), treat hypertension(1231)(1232) and hypotension during exhaustion of circulatory function(1217), coughing(1234)(12135), insomnia(1237), premenstrual syndrome (PMS)(1239), menopausal symptoms(1240), depression(1233), irritability(1233), erectile dysfunction (ED)(1238), lower cholesterol(1241) and regulate blood glucose(1233), improve memory(1222)(1223), etc.
by promoting function of lung and kidney channels(1217).

Phytochemical contituents(1217)
1. Schizandrin
2. Deoxyschisandrin
3. Gamma-schisandrin
4. Schisandrol
5. Pseudo-gamma-schisandrin
6. Schizandrate B
7. Gomisin A, B, C, F, G
8. Angeloylgomisin H
9. Tigloylgomisin H
10. Benzoylgomisin H
11. Epigomisin O
12. Malic acid
13. Citric acid
14. Tartaric acid
15. Succinic acid
16. A-pinene
17. Camphene
18. B-pinene
19. Byrcene
20. A-terpinene
21. Limonene
22. G-terpinene
23. P-cymene
24. Etc.

In chronic psychological stress male rat model, schisandra protect against stress induced complications such as carbohydrate metabolism(1227) and neurosis, psychogenic depression, astheno-depressive states, schizophrenia and alcoholism disorders(1233) and improved mental performance(1233).through its reduction of the levels of corticosterone (CORT) and glucose and protect the structure of the adrenal cortex(1227).
In physiological stress, the herbal medicine also exerted its stress-protective effect against a broad spectrum of harmful factors including heat shock, skin burn, cooling, frostbite, immobilisation, swimming under load in an atmosphere with decreased air pressure, aseptic inflammation, irradiation, and heavy metal intoxication(1233).
In oxidative stress induced damage heart(1242) tissues in animal models, schisandrin B (Sch B), a dibenzocyclooctadiene derivative isolated from the fruit of Schisandra chinensis attenuated cardiotoxicity via antioxidant and anti-inflammatory effects(1242). In oxidative stress induced liver damage, oral administration of Schisandra Lignans Extract (SLE)(1243)(1244) or triterpenoid(1245) a chemical constituent from Schisandra chinensis significantly reduced liver damage(1243)(1244)(1245) in experimental animal model, through its effects of balance of oxidation and reduction in cells(1243) or upregulating cell cycle progression(1244) and anti tumor antigen(1244), or ameliorating oxidative stress(1245).]

In metabolic syndrome, beside protecting against depression(1233), irritability(1233), high level of bad cholesterol(1241) and fluctuation of blood glucose(1233), memory lose(1222)(1223),... Schisandra also exhibited anti insulin resistance(1834)(1835), anti lipid disorder metabolism(1836) induced hypercholesterolemia(1837), anti hypertension(1838)(1839). suppressed carbohydrate disorder metabolism(1842) induced hyperglycemia(1843), obesity(1840)(1841),...... causing complications of diabetes(1844)(1845) and cardiovascular disease(1838)(1846)(1847).


Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


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References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women WithPolycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(1246) [Clinical study of area of Jiangsu province of polycystic ovarian syndrome correlation distribution of traditional Chinese medicine syndrome type and improper diet]. [Article in Chinese] by Feng Y, Gao YP.(PubMed)
(1247) [Preliminary study on relationship of disease-syndrome-symptom of ovulatory disorder infertility based on factor analysis]. [Article in Chinese] by Li M, Ma K, Shan, J.(PubMed)
(1247a) A Comprehensive Treatment of Polycystic Ovarian Syndrome (PCOS) by Liqin Zhao
(1834) Schisphenlignans A-E: five new dibenzocyclooctadiene lignans from Schisandra sphenanthera by Liang CQ1, Hu J, Shi YM, Shang SZ, Du X, Zhan R, Xiong WY, Zhang HB, Xiao WL, Sun HD.(PubMed)
(1835) Six new lignans from the leaves and stems of Schisandra sphenantheraby Liang CQ1, Hu J, Luo RH, Shi YM, Shang SZ, Gao ZH, Wang RR, Zheng YT, Xiong WY, Zhang HB, Xiao WL, Sun HD.(PubMed)
(1936) Dietary pulp from Fructus Schisandra Chinensis supplementation reduces serum/hepatic lipid and hepatic glucose levels in mice fed a normal or high cholesterol/bile salt diet by Sun N, Pan SY1, Zhang Y, Wang XY, Zhu PL, Chu ZS, Yu ZL, Zhou SF, Ko KM.(PubMed)
(1937) Dietary Fructus Schisandrae extracts and fenofibrate regulate the serum/hepatic lipid-profile in normal and hypercholesterolemic mice, with attention to hepatotoxicity by Pan SY1, Yu Q, Zhang Y, Wang XY, Sun N, Yu ZL, Ko KM.(PubMed)
(1838) Cardioprotective effects of aqueous Schizandra chinensis fruit extract on ovariectomized and balloon-induced carotid artery injury rat models: effects on serum lipid profiles and blood pressure. Kim EY1, Baek IH, Rhyu MR.(PubMed)
(1839) Therapeutic potential of Schisandra chinensis extracts for treatment of hypertension. Introduction to: 'antihypertensive effect of gomisin A from Schisandra chinensis on angiotensin II-induced hypertension via preservation of nitric oxide bioavailability' by Park et al. Alexander JS1, Wang Y.(PubMed)
(1840) Fatty acid synthase inhibitory activity of dibenzocyclooctadiene lignans isolated from Schisandra chinensis by Na M1, Hung TM, Oh WK, Min BS, Lee SH, Bae K.(PubMed)
(1841) The high throughput screening of neuropeptide FF2 receptor ligands from Korean herbal plant extracts by Do EU1, Piao LZ, Choi G, Choi YB, Kang TM, Shin J, Chang YJ, Nam HY, Kim HJ, Kim SI.(PubMed)
(1842) [Effects of fructus schisandrae on the function of the pituitary-testis axis and carbohydrate metabolism in rats undergoing experimental navigation and high-intensity exercise]. [Article in Chinese] by Xia P1, Sun LJ, Wang J.(PubMed)
(1843) The beneficial effects of combined grape pomace and omija fruit extracts on hyperglycemia, adiposity and hepatic steatosis in db/db mice: a comparison with major index compounds by Cho SJ1, Park HJ1, Jung UJ2, Kim HJ3, Moon BS4, Choi MS5.(PubMed)
(1844)Antidiabetic Effect of Schisandrae Chinensis Fructus Involves Inhibition of the Sodium Glucose Cotransporter by Qu Y1, Chan JY, Wong CW, Cheng L, Xu C, Leung AW, Lau CB.(PubMed)
(1845) Advanced glycation end-products inhibitors isolated from Schisandra grandiflora by Poornima B1, Anand Kumar D, Siva B, Venkanna A, Vadaparthi PR, Kumar K, Tiwari AK, Suresh Babu K.(PubMed)
(1846) The protective effects of Schisandra chinensis fruit extract and its lignans against cardiovascular disease: a review of the molecular mechanisms by Chun JN1, Cho M2, So I3, Jeon JH4.(PubMed)
(1847) Beneficial effects of schisandrin B on the cardiac function in mice model of myocardial infarction by Chen P1, Pang S, Yang N, Meng H, Liu J, Zhou N, Zhang M, Xu Z, Gao W, Chen B, Tao Z, Wang L, Yang Z.(PubMed)

Monday, December 28, 2015

The Holistic Clinical Trials and Studies of Polycystic Ovarian Syndrome: TCM Herbal Medicine for Kidney Yang deficiency - Ren Shen

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                    Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).

                    In Traditional Chinese Medicine Perspective
                               
While conventional medicine focus of using synthetic medication to induce ovulation and assisted artificial insemination for infertility couple, if the medicine fail, traditional Chinese medicine views polycystic ovarian syndrome in different approaches.Polycystic ovary syndrome, according to traditional Chinese medicine is a medical condition characterized by accumulative of fluid over a prolonged period of time causes of dampness and phlegms(247a)(247b) build up on the ovaries due to the effects of vary differentiations, affecting not only the women’s menstrual cycle, but also ovulation and fertility(1247a)(247b).

Dietary Suggestion, Life Style Modification and Nutritional Supplements according to TCM
According to Angela Warburton(1249), a doctor of Traditional Chinese Medicine practicing in Toronto, Canada, incorporating the proper dietary and lifestyle modifications, may make a BIG difference in the long-term for treatment of PCOs(1249).




PCOs Treatment according traditional Chinese medicine

Depending to differentiation, most common diagnosis of polycystic ovary syndrome can be classified into

Kidney yang deficiency

Along with common symptoms mentioned above, women with PCOs diagnosed with kidney yang deficiency may also experience yang vacuity induced cold expressive syndrome, including
lumbago, cold limbs, fatigue, cold aversion, feverish sensation in chest, palms and soles(1573),
difficulty in urination, enuresis, incontinence, declining libido and edema(1574) as a result of kidneys no longer perform their function in store fluid to moister and warm the body for healthy function in the body's organs and tissues, inducing adrenal insufficient chronic lower back pain(1575)(1580), depression(1575), hypothyroidism(1579)(1575), nephritis(1578)(1575), ...(1575), leading to failure in transform damp heat expression, promoted accentuation of inflammatory development of phlegm(1583).
Kidney yang deficiency has shown to alter carbohydrate and lipid metabolisms (free fatty acids, 1-monolinoleoylglycerol, and cholesterol), gut microbiota metabolism (indole-3-propionic acid), indued anovulatory infertility( 1581) and hypertension(1582) of which related to symptoms of PCOs(1576)(1577).



Herbal medicine for kidney yang deficiency
5. Panax ginseng(Ren Shen)(1779)
Ren Shen is also known as Ginseng, panax ginseng. The smells aromatic, tastes sweet and slightly warm herbs had been used in TCM as improved immune system(1781)(1782), anti cancer(1783)(1784)(1785), anti aging(1786)(1787), anti stress(1788)(1789), antioxidant(1790)(1791), anti inflammatory(1792)(1793),...... agent and to generate body liquids and allay thirst(1794), treat
nervous disorders(1794)(1795)(1796), anemia(1797)(1798), dyspnoea(1799)(1800), forgetfulness(1801) and confusion(1802), decreased libido(1803)(1804), chronic fatigue(1805)(1806), angina(1807), nausea and vomiting(1808),......as it strongly tonifies original qi, the spleen and lungs, by enhancing the functions of spleen and lung channels(1780).

Chemical constituents(1779)(1780)
1. Saponins
2. Panaxynol
3. Ginsenyne
4. Alpha pansinsene
5. Beta pansinsene
6. Beta farnesene
7. Bicyclogermacrene
8. Beta elemene
9. Gama elemene
10. Alpha neodovene
11. Beta neodovene
12. Alpha humulene
13. Beta humulene
14. Ccaryophyllene
15. Beta gurjunene
16. Alpha gurjunene
17. Alpha selinene
18. Beta selinene
19. Gama selinene
20. Selin-4, alpha guaiene
21. Gama cubebene
22. Beta patchoulene
23. Hepatadecanol-1
24. Etc.

Epidemiological literature found in data base of PubMed also suggested that panax ginseng also processes anti metabolic syndrome(1809)(1810)(1811), through its effect on insulin resistance(1812)(1813), fasting blood glucose(1814)(1815), hyperglycemia(1816)(1817), hyperlipidemia(1818)(1819)(1820), hypertension(1821)(1822), weight control(1823) and obesity(1823)(1824)(1825),.....as well as reducing risk of diabetes(1827)(1826)(1828) and cardiovascular disease(1829)(1830)(1831).
According to the research article dated 29 April 2014, the king of the herb has also found effectively for treatment of infertility of both sexes, including women with Polycystic ovary syndrome through lowering high numbers of antral follicles and increased the number of corpora lutea in the polycystic ovaries(1832).


All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women WithPolycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(1246) [Clinical study of area of Jiangsu province of polycystic ovarian syndrome correlation distribution of traditional Chinese medicine syndrome type and improper diet]. [Article in Chinese] by Feng Y, Gao YP.(PubMed)
(1247) [Preliminary study on relationship of disease-syndrome-symptom of ovulatory disorder infertility based on factor analysis]. [Article in Chinese] by Li M, Ma K, Shan, J.(PubMed)
(1247a) A Comprehensive Treatment of Polycystic Ovarian Syndrome (PCOS) by Liqin Zhao

(1779) Chinese Herbs – Ren Shen (Radix Ginseng) by Kyle J. Norton
(1780) ren shen (ginseng)(Complementary and Alternative Healing University)
(1781) Ginseng, the 'Immunity Boost': The Effects of Panax ginseng on Immune System by Kang S1, Min H.(PubMed)
(1782) [Comparative study of main components of ginseng on immune function of rats]. [Article in Chinese] by Jia ZY, Xie X, Wang XY, Jia W.(PubMed)
(1783) Ginsenoside Rp1 from Panax ginseng exhibits anti-cancer activity by down-regulation of the IGF-1R/Akt pathway in breast cancer cells by Kang JH1, Song KH, Woo JK, Park MH, Rhee MH, Choi C, Oh SH.(PubMed)
(1784) In vitro anti-cancer activity and structure-activity relationships of natural products isolated from fruits of Panax ginseng by Wang W1, Zhao Y, Rayburn ER, Hill DL, Wang H, Zhang R.(PubMed)
(1785) Pharmacokinetics and tissue distribution of 25-hydroxyprotopanaxadiol, an anti-cancer compound isolated from Panax ginseng, in athymic mice bearing xenografts of human pancreatic tumors by Hao M1, Wang W, Zhao Y, Zhang R, Wang H.(PubMed)
(1786) Ginsenoside Rg1 prevents cognitive impairment and hippocampus senescence in a rat model of D-galactose-induced aging. Zhu J1, Mu X1, Zeng J2, Xu C1, Liu J1, Zhang M1, Li C1, Chen J3, Li T3, Wang Y1.(PubMed)
(1787) [Research of anti-aging mechanism of ginsenoside Rg1 on brain]. [Article in Chinese] by Li CP, Zhang MS, Liu J, Geng S, Li J, Zhu JH, Zhang YY, Jia YY, Wang L, Wang SH, Wang YP.(PubMed)
(1788) Anti-stress effects of Ginkgo biloba and Panax ginseng: a comparative study by Rai D1, Bhatia G, Sen T, Palit G.(PubMed)
(1789) [The anti-stress effect of saponins extracted from panax ginseng fruit and the hypophyseal-adrenal system (author's transl)]. [Article in Chinese] by Zhang SC, Jiang XL.(PubMed)
(1790) Antioxidant effects of Panax ginseng C.A. Meyer in healthy subjects: a randomized, placebo-controlled clinical trial by Kim HG1, Yoo SR, Park HJ, Lee NH, Shin JW, Sathyanath R, Cho JH, Son CG.(PubMed)
(1791) Panax ginseng reduces oxidative stress and restores antioxidant capacity in aged rats by Ramesh T1, Kim SW, Hwang SY, Sohn SH, Yoo SK, Kim SK.(PubMed)
(1792) Panax ginseng C.A. Mayer G115 modulates pro-inflammatory cytokine production in mice throughout the increase of macrophage toll-like receptor 4 expression during physical stress by Pannacci M1, Lucini V, Colleoni F, Martucci C, Grosso S, Sacerdote P, Scaglione F.(PubMed)
(1793) Panax Potential analgesic and anti-inflammatory activities of Panax ginseng head butanolic fraction in animals by Lee JH1, Lee JH, Lee YM, Kim PN, Jeong CS.(PubMed)
(1794) Treatment with ginseng total saponins improves the neurorestoration of rat after traumatic brain injury by Hu BY1, Liu XJ2, Qiang R3, Jiang ZL4, Xu LH1, Wang GH1, Li X1, Peng B1.(PubMed)
(1795) [Advance in studies of Panax notoginseng saponins on pharmacological mechanism of nervous system disease]. [Article in Chinese] by Su P, Wang L, Du SJ, Xin WF, Zhang WS.(PubMed)
(1796) Neuroprotective effect of pseudoginsenoside-f11 on a rat model of Parkinson's disease induced by 6-hydroxydopamine by Wang JY1, Yang JY1, Wang F1, Fu SY1, Hou Y1, Jiang B1, Ma J1, Song C1, Wu CF1.(PubMed)
(1797) The haematopoietic effect of Panax japonicus on blood deficiency model mice by Zhang H1, Wang HF2, Liu Y3, Huang LJ3, Wang ZF4, Li Y5.(PubMed)
(1798) [Effect of Panax notoginsenosides on the proliferation of hematopoietic progenitor cells in mice with immune-mediated aplastic anemia]. [Article in Chinese] by Gai Y1, Gao RL, Niu YP.(PubMed)

(1799) Korean ginseng-induced occupational asthma and determination of IgE binding components by Kim KM1, Kwon HS, Jeon SG, Park CH, Sohn SW, Kim DI, Kim SS, Chang YS, Kim YK, Cho SH, Min KU, Kim YY.(PubMed)
(1800) [Acute massive pulmonary embolism in a patient using clavis panax]. [Article in Turkish] by Yüksel IO1, Arslan S, Cağırcı G, Yılmaz A.(PubMed)
(1801) Effect of Memo®, a natural formula combination, on Mini-Mental State Examination scores in patients with mild cognitive impairment by Yakoot M1, Salem A, Helmy S.(PubMed)
(1802) Evaluation of the ergogenic properties of ginseng: an update by Bahrke MS1, Morgan WR.(PubMed)
(1803) [Treatment with carnitine, acetyl carnitine, L-arginine and ginseng improves sperm motility and sexual health in men with asthenopermia]. [Article in Italian] by Morgante G1, Scolaro V, Tosti C, Di Sabatino A, Piomboni P, De Leo V.(PubMed)
(1804) Effects of Korean red ginseng on sexual arousal in menopausal women: placebo-controlled, double-blind crossover clinical study by Oh KJ1, Chae MJ, Lee HS, Hong HD, Park K.(PubMed)
(1805) Antifatigue effects of Panax ginseng C.A. Meyer: a randomised, double-blind, placebo-controlled trial by Kim HG1, Cho JH, Yoo SR, Lee JS, Han JM, Lee NH, Ahn YC, Son CG.(PubMed)
(1806) High-Dose Asian Ginseng (Panax Ginseng) for Cancer-Related Fatigue: A Preliminary Report by Yennurajalingam S1, Reddy A2, Tannir NM3, Chisholm GB4, Lee RT5, Lopez G5, Escalante CP6, Manzullo EF6, Frisbee Hume S2, Williams JL2, Cohen L5, Bruera E2.(PubMed)
(1807) 16 cases of coronary angina pectoris treated with powder composed of radix ginseng, radix notoginseng and succinum by Yuan J1, Guo W, Yang B, Liu P, Wang Q, Yuan H.(PubMed)
(1808) Effects of Korean red ginseng extract on cisplatin-induced nausea and vomiting by Kim JH1, Yoon IS, Lee BH, Choi SH, Lee JH, Lee JH, Jeong SM, Kim SC, Park CK, Lee SM, Nah SY.(PubMed)
(1809) Effects of Korean Red Ginseng on Cardiovascular Risks in Subjects with Metabolic Syndrome: a Double-blind Randomized Controlled Study by Park BJ1, Lee YJ, Lee HR, Jung DH, Na HY, Kim HB, Shim JY.(PubMed)
(1810) Vinegar-processed ginseng radix improves metabolic syndrome induced by a high fat diet in ICR mice by Yun SN1, Ko SK, Lee KH, Chung SH(PubMed)
(1811) Traditional chinese medicine in treatment of metabolic syndrome by Yin J1, Zhang H, Ye J.(PubMed)
(1812) Amelioration of insulin resistance by Rk1 + Rg5 complex under endoplasmic reticulum stress conditions by Ponnuraj SP1, Siraj F1, Kang S1, Noh HY1, Min JW1, Kim YJ1, Yang DC1.(PubMed)
(1813) Improvement of insulin resistance by panax ginseng in fructose-rich chow-fed rats by Liu TP1, Liu IM, Cheng JT.(PubMed)
(1814) The effect of ginseng (the genus panax) on glycemic control: a systematic review and meta-analysis of randomized controlled clinical trials by Shishtar E1, Sievenpiper JL2, Djedovic V1, Cozma AI1, Ha V1, Jayalath VH1, Jenkins DJ3, Meija SB1, de Souza RJ4, Jovanovski E1, Vuksan V3.(PubMed)
(1815) Postprandial glucose-lowering effects of fermented red ginseng in subjects with impaired fasting glucose or type 2 diabetes: a randomized, double-blind, placebo-controlled clinical trial by Oh MR, Park SH, Kim SY, Back HI, Kim MG, Jeon JY, Ha KC, Na WT, Cha YS, Park BH, Park TS1, Chae SW.(PubMed)
(1816) Anti-hyperglycemic effect of fermented ginseng in type 2 diabetes mellitus mouse model by Jeon WJ1, Oh JS, Park MS, Ji GE.(PubMed)
(1817) Anti-hyperglycemic effects of ginseng: comparison between root and berry by Dey L1, Xie JT, Wang A, Wu J, Maleckar SA, Yuan CS.(PubMed)
(1818) Anti-atherogenic action of panax ginseng in rats and in patients with hyperlipidemia by Yamamoto M1, Kumagai A.(PubMed)
(1819) Serum HDL-cholesterol-increasing and fatty liver-improving actions of Panax ginseng in high cholesterol diet-fed rats with clinical effect on hyperlipidemia in man by Yamamoto M, Uemura T, Nakama S, Uemiya M, Kumagai A.(PubMed)
(1820) Orally administered ginseng extract reduces serum total cholesterol and triglycerides that induce fatty liver in 66% hepatectomized rats by Cui X1, Sakaguchi T, Ishizuka D, Tsukada K, Hatakeyama K.(PubMed)
(1821) Effect of panax notoginseng saponins injection on the p38MAPK pathway in lung tissue in a rat model of hypoxic pulmonary hypertension by Zhao S1, Zheng MX, Chen HE, Wu CY, Wang WT.(PubMed)
(1822) Negligible pharmacokinetic interaction of red ginseng and antihypertensive agent amlodipine in Sprague-Dawley rats by Ryu SH1, Kim JW, Kim YS, Lee SH, Cho YB, Lee HK, Kim YG, Jeong WS, Kim KB.(PubMed)
(1823) Effect of ginsam, a vinegar extract from Panax ginseng, on body weight and glucose homeostasis in an obese insulin-resistant rat model by Lim S1, Yoon JW, Choi SH, Cho BJ, Kim JT, Chang HS, Park HS, Park KS, Lee HK, Kim YB, Jang HC.(PubMed)
(1824) Weight gain reduction in mice fed Panax ginseng saponin, a pancreatic lipase inhibitor by Karu N1, Reifen R, Kerem Z.(PubMed)
(1825) Anti-obesity effects of chikusetsusaponins isolated from Panax japonicus rhizomes by Han LK1, Zheng YN, Yoshikawa M, Okuda H, Kimura Y.(PubMed)
(1826) Korean red ginseng (Panax ginseng) improves insulin sensitivity and attenuates the development of diabetes in Otsuka Long-Evans Tokushima fatty rats by Lee HJ1, Lee YH, Park SK, Kang ES, Kim HJ, Lee YC, Choi CS, Park SE, Ahn CW, Cha BS, Lee KW, Kim KS, Lim SK, Lee HC.(PubMed)
(1827) Ginseng modifies the diabetic phenotype and genes associated with diabetes in the male ZDF rat by Banz WJ1, Iqbal MJ, Bollaert M, Chickris N, James B, Higginbotham DA, Peterson R, Murphy L.(PubMed)
(1828) Antidiabetic effects of malonyl ginsenosides from Panax ginseng on type 2 diabetic rats induced by high-fat diet and streptozotocin by Liu Z1, Li W, Li X, Zhang M, Chen L, Zheng YN, Sun GZ, Ruan CC.(PubMed)
(1829) Ginseng extracts restore high-glucose induced vascular dysfunctions by altering triglyceride metabolism and downregulation of atherosclerosis-related genes by Chan GH1, Law BY, Chu JM, Yue KK, Jiang ZH, Lau CW, Huang Y, Chan SW, Ying-Kit Yue P, Wong RN.(PubMed)
(1830) Merit of ginseng in the treatment of heart failure in type 1-like diabetic rats by Tsai CC1, Chan P2, Chen LJ3, Chang CK4, Liu Z5, Lin JW4.(PubMed)
(1831) Ginseng is useful to enhance cardiac contractility in animals by Lin JW1, Cherng YG2, Chen LJ3, Niu HS4, Chang CK1, Niu CS4.(PubMed)

(1832) Herbal Ginseng and Infertility by Kyle J. Norton.

Sunday, December 27, 2015

The Holistic Clinical Trials and Studies of Polycystic Ovarian Syndrome: TCM Herbal Medicine for Kidney Yang deficiency - Gou Qi Zi

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                    Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).

                    In Traditional Chinese Medicine Perspective
                               
While conventional medicine focus of using synthetic medication to induce ovulation and assisted artificial insemination for infertility couple, if the medicine fail, traditional Chinese medicine views polycystic ovarian syndrome in different approaches.Polycystic ovary syndrome, according to traditional Chinese medicine is a medical condition characterized by accumulative of fluid over a prolonged period of time causes of dampness and phlegms(247a)(247b) build up on the ovaries due to the effects of vary differentiations, affecting not only the women’s menstrual cycle, but also ovulation and fertility(1247a)(247b).

Dietary Suggestion, Life Style Modification and Nutritional Supplements according to TCM
According to Angela Warburton(1249), a doctor of Traditional Chinese Medicine practicing in Toronto, Canada, incorporating the proper dietary and lifestyle modifications, may make a BIG difference in the long-term for treatment of PCOs(1249).




PCOs Treatment according traditional Chinese medicine

Depending to differentiation, most common diagnosis of polycystic ovary syndrome can be classified into

Kidney yang deficiency

Along with common symptoms mentioned above, women with PCOs diagnosed with kidney yang deficiency may also experience yang vacuity induced cold expressive syndrome, including
lumbago, cold limbs, fatigue, cold aversion, feverish sensation in chest, palms and soles(1573),
difficulty in urination, enuresis, incontinence, declining libido and edema(1574) as a result of kidneys no longer perform their function in store fluid to moister and warm the body for healthy function in the body's organs and tissues, inducing adrenal insufficient chronic lower back pain(1575)(1580), depression(1575), hypothyroidism(1579)(1575), nephritis(1578)(1575), ...(1575), leading to failure in transform damp heat expression, promoted accentuation of inflammatory development of phlegm(1583).
Kidney yang deficiency has shown to alter carbohydrate and lipid metabolisms (free fatty acids, 1-monolinoleoylglycerol, and cholesterol), gut microbiota metabolism (indole-3-propionic acid), indued anovulatory infertility( 1581) and hypertension(1582) of which related to symptoms of PCOs(1576)(1577).



Herbal medicine for kidney yang deficiency

4. Lycium chinense(Qi Zi)(1759)
Gou Qi Zi or Qi Zi is also known as wolfberry fruit. The sweet and neutral herb has been used in TCM as anti cancer(1748)(1749)(1750), antiviral(1751), and antiinflammatory(1751) agent and to treat weakness(1768) mental acuity(1768), shortness of breath(1768), memory and neurogenesis impairments(1752), relieve pain(1753) improve vision(1754)(1755), anemia(1754), diabetes(1756), promote antiaging(1757), enhance immune system(1751), heart function(1751), lower blood lipids(1751), modulate estrogen receptors(1750) etc., as it nourishes and tonifies liver and kidneys by enhancing the functions of liver, lung and kidney channels(1758).

Chemical constituents(1758)
1. Betaine
2. β-sitosterol
3. Linoleic acid
4. Physalien
5. Cryptoxanthin
6. Atropine
7. Hyoscyamine
8. Scopoletin
9. Amino acids
10. Physalein
11. Zeaxanthin
12. Dipalmitate
13. Carotene
14. Etc.


Epidemiologically, wolfberry also processed anti oxidant(1763)(1762) and anti inflammatory(1765)(1764), anti insulin resistance(1760)(1761), anti depression(1767), sleep disorder(1768), anti stress(1768), anti mental deficits(1768) and anti metabolic syndrome(1766), through its enhanced carbohydrate(1770), lipid(1766) and other metabolic(1766) mechanisms, including fasting glucose(1770), hypertensive(1771)(1772), anti hyperglycaemic(1769)(1770)(1774), anti hyperlipidemic(1773)(1774), weight gain(1770), obesity, ,,, of which induced protective effects against the development of diabetes(1775)(1776) and cardiovascular disease(1777)(1751)(1778).

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/

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References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women WithPolycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(1246) [Clinical study of area of Jiangsu province of polycystic ovarian syndrome correlation distribution of traditional Chinese medicine syndrome type and improper diet]. [Article in Chinese] by Feng Y, Gao YP.(PubMed)
(1247) [Preliminary study on relationship of disease-syndrome-symptom of ovulatory disorder infertility based on factor analysis]. [Article in Chinese] by Li M, Ma K, Shan, J.(PubMed)
(1247a) A Comprehensive Treatment of Polycystic Ovarian Syndrome (PCOS) by Liqin Zhao


(1748) Lycium barbarum polysaccharides induce apoptosis in human prostate cancer cells and inhibits prostate cancer growth in a xenograft mouse model of human prostate cancer by Luo Q1, Li Z, Yan J, Zhu F, Xu RJ, Cai YZ.(PubMed)
(1749) [Observation of the effects of LAK/IL-2 therapy combining with Lycium barbarum polysaccharides in the treatment of 75 cancer patients]. [Article in Chinese] by Cao GW1, Yang WG, Du P.(PubMed)
(1750) Lycium barbarum inhibits growth of estrogen receptor positive human breast cancer cells by favorably altering estradiol metabolism by Li G1, Sepkovic DW, Bradlow HL, Telang NT, Wong GY.(PubMed)
(1751) An evidence-based update on the pharmacological activities and possible molecular targets of Lycium barbarum polysaccharides by Cheng J1, Zhou ZW2, Sheng HP3, He LJ4, Fan XW5, He ZX6, Sun T7, Zhang X8, Zhao RJ9, Gu L10, Cao C2, Zhou SF11.(PubMed)
(1752) Lycium barbarum polysaccharides prevent memory and neurogenesis impairments in scopolamine-treated rats by Chen W1, Cheng X2, Chen J3, Yi X2, Nie D4, Sun X5, Qin J2, Tian M2, Jin G2, Zhang X2.(PubMed)
(1753) [Effects of lycium barbarum polysaccharide on formation of traumatic neuroma and pain after transection of sciatic nerve in rats]. [Article in Chinese] by Fan H1, Deng C, Fu J, Ding L, Yin G, Ma Y.(PubMed)
(1754) Lycium (Lycium barbarum) by Cassileth B1.(PubMed)
(1755) Goji berry effects on macular characteristics and plasma antioxidant levels by Bucheli P1, Vidal K, Shen L, Gu Z, Zhang C, Miller LE, Wang J.(PubMed)
(1756) Anti-diabetic effects of the ethanol extract of a functional formula diet in mice fed with a fructose/fat-rich combination diet by Cheng Q1, Zhang X, Wang O, Liu J, Cai S, Wang R, Zhou F, Ji B.(PubMed)
(1757) Comparative evaluation of the antioxidant effects of the natural vitamin C analog 2-O-β-D-glucopyranosyl-L-ascorbic acid isolated from Goji berry fruit by Zhang Z1, Liu X, Zhang X, Liu J, Hao Y, Yang X, Wang Y.(PubMed)
(1758) Qi Zi(Complementary and Alternative Healing University)
(1759) Chinese Herbs – Gou Qi Zi or Qi Zi (Fructus Lycii) by Kyle J. Norton
(1760) A diet formula of Puerariae radix, Lycium barbarum, Crataegus pinnatifida, and Polygonati rhizoma alleviates insulin resistance and hepatic steatosis in CD-1 mice and HepG2 cellsby Liu J1, Zhang H, Ji B, Cai S, Wang R, Zhou F, Yang J, Liu H.(PubMed)
(1761) Dietary Lycium barbarum polysaccharide induces Nrf2/ARE pathway and ameliorates insulin resistance induced by high-fat via activation of PI3K/AKT signaling by Yang Y1, Li W2, Li Y2, Wang Q2, Gao L3, Zhao J4.(PubMed)
(1762) Lycium barbarum (goji) juice improves in vivo antioxidant biomarkers in serum of healthy adults by Amagase H1, Sun B, Borek C.(PubMed)
(1763) Effect of drying methods on physicochemical properties and antioxidant activities of wolfberry (Lycium barbarum) polysaccharide by Zhao Q1, Dong B2, Chen J2, Zhao B3, Wang X1, Wang L1, Zha S4, Wang Y1, Zhang J5, Wang Y5.(PubMed)
(1764) Anti-inflammatory effect of Lycii radicis in LPS-stimulated RAW 264.7 macrophages by Song MY1, Jung HW, Kang SY, Kim KH, Park YK.(PubMed)
(1765) Anti-inflammatory effect of Lycium Fruit water extract in lipopolysaccharide-stimulated RAW 264.7 macrophage cells by Oh YC1, Cho WK, Im GY, Jeong YH, Hwang YH, Liang C, Ma JY.(PubMed)
(1766) Metabolic Signatures of Kidney Yang Deficiency Syndrome and Protective Effects of Two Herbal Extracts in Rats Using GC/TOF by MS. Zhao L1, Wu H, Qiu M, Sun W, Wei R, Zheng X, Yang Y, Xin X, Zou H, Chen T, Liu J, Lu L, Su J, Ma C, Zhao A, Jia W.(PubMed)
(1767) Synaptic plasticity, but not hippocampal neurogenesis, mediated the counteractive effect of wolfberry on depression in rats(1) by Zhang E1, Yau SY, Lau BW, Ma H, Lee TM, Chang RC, So KF.(PubMed)
(1768) A meta-analysis of clinical improvements of general well-being by a standardized Lycium barbarum by Paul Hsu CH1, Nance DM, Amagase H.(PubMed)
(1769) Evaluation of hypoglycemic activity of the polysaccharides extracted from Lycium barbarum by Jing L1, Cui G, Feng Q, Xiao Y.(PubMed)
(1770) Hypoglycemic effects and mechanisms of action of Cortex Lycii Radicis on alloxan-induced diabetic mice by Gao D1, Li Q, Liu Z, Li Y, Liu Z, Fan Y, Li K, Han Z, Li J.(PubMed)
(1771) Protection of retinal ganglion cells and retinal vasculature by Lycium barbarum polysaccharides in a mouse model of acute ocular hypertension by Mi XS1, Feng Q, Lo AC, Chang RC, Lin B, Chung SK, So KF.(PubMed)
(1772) Goji (Lycium barbarum and L. chinense): Phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity by Potterat O1.(PubMed)
(1773) Effects of Lycium barbarum polysaccharides on oxidative stress in hyperlipidemic mice following chronic composite psychological stress intervention by Zhu X1, Hu S1, Zhu L1, Ding J1, Zhou Y1, Li G1.(PubMed)
(1774) Hypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum by Luo Q1, Cai Y, Yan J, Sun M, Corke H..(PubMed)
(1775) Practical Application of Antidiabetic Efficacy of Lycium barbarum Polysaccharide in Patients with Type 2 Diabetes by Cai H, Liu F, Zuo P, Huang G, Song Z, Wang T, Lu H, Guo F, Han C, Sun G1.(PubMed)
(1776) Characterization and hypoglycemic effect of a polysaccharide extracted from the fruit of Lycium barbarum L. by Zhu J1, Liu W, Yu J, Zou S, Wang J, Yao W, Gao X.(PubMed)
(1777) Lycium barbarum polysaccharides reduce intestinal ischemia/reperfusion injuries in rats by Yang X1, Bai H, Cai W, Li J, Zhou Q, Wang Y, Han J, Zhu X, Dong M, Hu D.(PubMed)
(1778) [Effect of Lycium ruthenicum anthocyanins on atherosclerosis in mice]. [Article in Chinese] by Lin L1, Li J, Lv H, Ma Y, Qian Y.(PubMed)

Thursday, December 24, 2015

The Holistic Clinical Trials and Studies of Polycystic Ovarian Syndrome: TCM Herbal Medicine for Kidney Yang deficiency - Di Huang

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                    Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).

                    In Traditional Chinese Medicine Perspective
                               
While conventional medicine focus of using synthetic medication to induce ovulation and assisted artificial insemination for infertility couple, if the medicine fail, traditional Chinese medicine views polycystic ovarian syndrome in different approaches.Polycystic ovary syndrome, according to traditional Chinese medicine is a medical condition characterized by accumulative of fluid over a prolonged period of time causes of dampness and phlegms(247a)(247b) build up on the ovaries due to the effects of vary differentiations, affecting not only the women’s menstrual cycle, but also ovulation and fertility(1247a)(247b).

Dietary Suggestion, Life Style Modification and Nutritional Supplements according to TCM
According to Angela Warburton(1249), a doctor of Traditional Chinese Medicine practicing in Toronto, Canada, incorporating the proper dietary and lifestyle modifications, may make a BIG difference in the long-term for treatment of PCOs(1249).




PCOs Treatment according traditional Chinese medicine

Depending to differentiation, most common diagnosis of polycystic ovary syndrome can be classified into

Kidney yang deficiency

Along with common symptoms mentioned above, women with PCOs diagnosed with kidney yang deficiency may also experience yang vacuity induced cold expressive syndrome, including
lumbago, cold limbs, fatigue, cold aversion, feverish sensation in chest, palms and soles(1573),
difficulty in urination, enuresis, incontinence, declining libido and edema(1574) as a result of kidneys no longer perform their function in store fluid to moister and warm the body for healthy function in the body's organs and tissues, inducing adrenal insufficient chronic lower back pain(1575)(1580), depression(1575), hypothyroidism(1579)(1575), nephritis(1578)(1575), ...(1575), leading to failure in transform damp heat expression, promoted accentuation of inflammatory development of phlegm(1583).
Kidney yang deficiency has shown to alter carbohydrate and lipid metabolisms (free fatty acids, 1-monolinoleoylglycerol, and cholesterol), gut microbiota metabolism (indole-3-propionic acid), indued anovulatory infertility( 1581) and hypertension(1582) of which related to symptoms of PCOs(1576)(1577).



Herbal medicine for kidney yang deficiency


3. Rehmannia glutinosa Liboschitz var. purpurae(Di Huang)
Di huang can be sheng (raw) or Shu (cooked) and is also known as Rehmannia
Sheng di huang(The bitter, sweet, bitter cold in nature) and Shu di huang (The bitter, sweet, bitter and warm in nature)(1724) has been used in TCM as diuretic(1734), anti hyperglycemicagent(1726), anti cancers(1731)(1732) and to treat cough(1743), asthma(1744)(1746), lung inflammation induced shortness of breath(1745), and wheezing(1746), tinnitus(1747) and hearing loss(17447), poor memory(1741), bronchial contraction)1746), and chest tightness(1746), lower plasma glucose(1725)(1727), enhance heart function(1734)(1735) (small doses constrict the blood vessels and large doses dilate the blood vessel)(1724), and regulate steroid hormone(1736),..... by promoting the functions of heart, kidney, and liver channels(1724).

Chemical constituents(1724)
1. Leonuride
2. Aucubin
3. Catalpol
4. Melittoside
5. Melittoside
6. Rehmannioside A、B、C、D
7. 8-epiloganic acid 8
8. Ajugoside
9. Lysine
10. Histidine
11. Arginine
12. Sapartic acid
13. Glutamic acid)
14. Threonine
15. Serine
16. Gluycine
17. Alanine
18. Valine
19. Isoleucine
20. Leucine
21. Tyrosine
22. Phenylalnine
23. Etc.


Epidemiological studies proposed that rehmannia also displays anti metabolic syndrome(1728), including fatigue(1728), prediabetes(1728)(1737), LDL-C, hypertension(1729), lipid profile(1728)(1737), including total cholesterol (TC), triglyceride (TG), high and low density lipoprotein cholesterol (HDL-C, LDL-C)(1736)(1737), insulin resistance(1730), waist size(1736) and obesity(1742), through its effects in carbohydrate(1740)(1741) and lipid metabolism(1728) of which reduce risk of diabetes(1728)(1739) and cardiovascular disease(1728)(1736).
According to Kyung Hee University. formula Kyung-Ok-Ko, containing rehmannia, prevented and alleviated dehydroepiandrosterone-induced polycystic ovarian syndrome in rats model(1738).

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women WithPolycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(1246) [Clinical study of area of Jiangsu province of polycystic ovarian syndrome correlation distribution of traditional Chinese medicine syndrome type and improper diet]. [Article in Chinese] by Feng Y, Gao YP.(PubMed)
(1247) [Preliminary study on relationship of disease-syndrome-symptom of ovulatory disorder infertility based on factor analysis]. [Article in Chinese] by Li M, Ma K, Shan, J.(PubMed)
(1247a) A Comprehensive Treatment of Polycystic Ovarian Syndrome (PCOS) by Liqin Zhao

(1724) Di Huang(Complementary and Alternative Healing University)
(1725) Stachyose extract from Rehmannia glutinosa Libosch. to lower plasma glucose in normal and diabetic rats by oral administration by Zhang RX1, Jia ZP, Kong LY, Ma HP, Ren J, Li MX, Ge X.(PubMed)
(1726) Hypoglycemic effect of Rehmannia glutinosa oligosaccharide in hyperglycemic and alloxan-induced diabetic rats and its mechanism by Zhang R1, Zhou J, Jia Z, Zhang Y, Gu G.(PubMed)
(1727) Plasma glucose lowering mechanisms of catalpol, an active principle from roots of Rehmannia glutinosa, in streptozotocin-induced diabetic rats by Shieh JP1, Cheng KC, Chung HH, Kerh YF, Yeh CH, Cheng JT.(PubMed)
(1728) Evaluation of symptom, clinical chemistry and metabolomics profiles during Rehmannia six formula (R6) treatment: an integrated and personalized data analysis approach by van Wietmarschen HA1, van der Greef J, Schroën Y, Wang M.(PubMed)
(1729) The protective effect of Liu-Wei-Di-Huang-Fang in salt-sensitive hypertension rats byYang Q1, He Y, Wang W.(PubMed)
(1730) [Effect of Rehmannia glutinosa water extraction on insulin resistance and gene expression of resistin in type 2 diabetes mellitus rats]. [Article in Chinese] by Lv XF1, Meng QY, Guo XM.(PubMed)
(1731) Catalpol Inhibited the Proliferation of T24 Human Bladder Cancer Cells by Inducing Apoptosis Through the Blockade of Akt-Mediated Anti-apoptotic Signaling by Jin D1, Cao M, Mu X, Yang G, Xue W, Huang Y, Chen H.(PubMed)
(1732) Hot water-extracted Lycium barbarum and Rehmannia glutinosa inhibit proliferation and induce apoptosis of hepatocellular carcinoma cells by Chao JC1, Chiang SW, Wang CC, Tsai YH, Wu MS.(PubMed)
(1733) Oriental medicine Kyung-Ok-Ko prevents and alleviates dehydroepiandrosterone-induced polycystic ovarian syndrome in rats by Jang M1, Lee MJ1, Lee JM2, Bae CS3, Kim SH4, Ryu JH5, Cho IH6.(PubMed)
(1734) Catalpol decreases peroxynitrite formation and consequently exerts cardioprotective effects against ischemia/reperfusion insult byHuang C1, Cui Y, Ji L, Zhang W, Li R, Ma L, Xing W, Zhou H, Chen B, Yu J, Zhang H.(PubMed)
(1735) Saeng-Ji-Hwang has a protective effect on adriamycin-induced cytotoxicity in cardiac muscle cells by Chae HJ1, Kim HR, Kim DS, Woo ER, Cho YG, Chae SW.(PubMed)
(1736) [Effect of dandi tablet on blood lipids and sex hormones in women of postmenopausal stage]. [Article in Chinese] by Liang R1, Chen MR, Xu X.(PubMed)
(1737) Rehmannia glutinosa (Gaertn.) DC. polysaccharide ameliorates hyperglycemia, hyperlipemia and vascular inflammation in streptozotocin-induced diabetic mice by Zhou J1, Xu G2, Yan J2, Li K2, Bai Z2, Cheng W2, Huang K3.(PubMed)
(1738) Oriental medicine Kyung-Ok-Ko prevents and alleviates dehydroepiandrosterone-induced polycystic ovarian syndrome in rats by Jang M1, Lee MJ1, Lee JM2, Bae CS3, Kim SH4, Ryu JH5, Cho IH6.(PubMed)
(1739) Antidiabetic Effects of Carassius auratus Complex Formula in High Fat Diet Combined Streptozotocin-Induced Diabetic Mice by Wang ZH1, Hsu CC2, Lin HH3, Chen JH2.(PubMed)
(1740) Ameliorating effect and potential mechanism of Rehmannia glutinosa oligosaccharides on the impaired glucose metabolism in chronic stress rats fed with high-fat diet by Zhang R1, Zhou J2, Li M2, Ma H3, Qiu J2, Luo X4, Jia Z5.(PubMed)
(1741) d-galactose administration induces memory loss and energy metabolism disturbance in mice: protective effects of catalpol by Zhang XL1, An LJ, Bao YM, Wang JY, Jiang B.(PubMed)
(1742) Rehmannia inhibits adipocyte differentiation and adipogenesis by Jiang L1, Zhang NX, Mo W, Wan R, Ma CG, Li X, Gu YL, Yang XY, Tang QQ, Song HY.(PubMed)
(1743) The effect of a traditional Chinese prescription for a case of lung carcinoma by Kamei T1, Kumano H, Iwata K, Nariai Y, Matsumoto T.(PubMed)
(1744) The effects of the standardized herbal formula PM014 on pulmonary inflammation and airway responsiveness in a murine model of cockroach allergen-induced asthma by Jung KH1, Choi HL2, Park S3, Lee G4, Kim M5, Min JK6, Min BI7, Bae H8.(PubMed)
(1745) [Shengdi injection on rat model of lung inflammation induced by lipopolysaccharides]. [Article in Chinese] by Liu L1, Tang L, Xu DS, Xia HL, Xie QM.(PubMed)
(1746) The effects of the standardized herbal formula PM014 on pulmonary inflammation and airway responsiveness in a murine model of cockroach allergen-induced asthma by Jung KH1, Choi HL2, Park S3, Lee G4, Kim M5, Min JK6, Min BI7, Bae H8.(PubMed)
(1747) Rehmannia glutinosa activates intracellular antioxidant enzyme systems in mouse auditory cells by Yu HH1, Kim YH, Jung SY, Shin MK, Park RK, So HS, Kim KY, Lee DH, You YO.(PubMed)