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Thursday, April 7, 2016

The Smoothie of Green Tea and Grape for Prevention and Treatment of Bright's disease

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced risk of Bright's disease
Yield: 2 servings (about 8 ounces each)
1 1/2 cups grape
1 cup green tea drink 1 cup green tea drink (Make from 4 grams(2 tea bags) of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and set aside for cooling to room temperature)

1. Place the celery, apple with peels, green tea, in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

Bright's disease a disease involved chronic inflammation of the kidneys, characterized by the presence blood in the urine and is frequently accompanied by edema and hypertension.

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. Its phytochemical epigallocatechin-3-gallate (EGCG), inhibited Bright's disease through regulation of oxidative stress and pro inflammatory cytokines NF-κB and Nrf2 signalling pathways(1).
Accoridng to the joint study led by the Shengjing Hospital of China Medical University, epigallocatechin-3-gallate (EGCG) also exhibited renoprotective effect through alleviated inflammatory responses alleviation and inhibited TGF-β/Smad signaling pathway in regulation of cell growth, differentiation in animal model(2).

Resveratrol, a phytochemical in the class of Stilbenoids, found abundantly in grape and blueberry may be beneficiary for patients with Bright's disease(3). According to the University of Yamanashi, resveratrol, a natural polyphenolic phytoalexin, also showed to inhibited inflammation of Intraglomerular mesangial cells in kidney through regulation of NF-κB, a prototypical proinflammatory signaling pathway(4).
Furthermore, the phytochemical reduced damage to the kidneys.through attenuated the presence of abnormal quantities of protein in the urine, Dr. Nihei T and professors at the Tokyo Noko University, insisted(5).

The effectiveness of  Green Tea and Grape may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk and treatment of Bright's disease with little or no adverse effects.

People who are at high risk of Bright's disease due to aging, weaken reno function... should drink at least one serving daily and people with Bright's disease should drink no more than 4 servings daily, depending to digestive toleration.
Life style and diet pattern change are necessary.

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References
(1) Epigallocatechin-3-Gallate Attenuates Oxidative Stress and Inflammation in Obstructive Nephropathy via NF-κB and Nrf2/HO-1 Signalling Pathway Regulation by Wang Y1, Wang B2, Du F1, Su X1, Sun G1, Zhou G1, Bian X1, Liu N3.(PubMed)
(2) Epigallocatechin-3-gallate attenuates unilateral ureteral obstruction-induced renal interstitial fibrosisin mice by Wang Y1, Wang B2, Du F2, Su X2, Sun G2, Zhou G2, Bian X2, Liu N2.(PubMed)
(3) Resveratrol ameliorates renal damage, increases expression of heme oxygenase-1, and has anti-complement, anti-oxidative, and anti-apoptotic effects in a murine model of membranous nephropathy by Wu CC1, Huang YS2, Chen JS3, Huang CF4, Su SL5, Lu KC6, Lin YF7, Chu P3, Lin SH3, Sytwu HK8.(PubMed)
(4) Enhancement of NF-kappaB activity by resveratrol in cytokine-exposed mesangial cells by Uchida Y1, Yamazaki H, Watanabe S, Hayakawa K, Meng Y, Hiramatsu N, Kasai A, Yamauchi K, Yao J, Kitamura M.(PubMed)
(5) Inhibitory effect of resveratrol on proteinuria, hypoalbuminemia and hyperlipidemia in nephritic rats. by Nihei T1, Miura Y, Yagasaki K.(PubMed)

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