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Wednesday, May 18, 2016

The Smoothie of Carrot, Olive and Curcumin for Prevention and Treatment of Poor Vision in Conorenal syndrome

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Conorenal syndrome, also known as Mainzer-Saldino syndrome or Saldino-Mainzer disease is a medical condition of diseases involved kidney, skeletal system and eye.

Poor vision in Conorenal syndrome is a result of a progression of degeneration of photosensitive tissue of the retina in both eyes of patient since infancy.
Treatment of poor vision with natural sources may be helpful to prolong at least and prevent the destruction of the photosensitive tissues

The smoothie at least prolong and prevention of poor vision in Conorenal syndrome 
Yield: 2 servings (about 8 ounces each)

1/2 cup carrot
1 cup olive
1 tsp curcumin
1 cup rice milk

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately


The finding of a natural source for treatment of Poor Vision in Conorenal syndrome has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Recent studies back by well known institutions proposed, Cooked Sweet Potato, Olive and Grape Juice may be the next generation of natural ingredients for prevention and treatment of poor vision in Conorenal syndrome.

Carotene, an orange or red plant pigment and a precursor of vitamin A found abundantly in carrot and tomato may benefits patient with poor vision(1) in Conorenal syndrome. According to Case Western Reserve University, synthetic 9-cis-stereoisomers of vitamin A (all-trans-retinol) are especially promising agents for the fight against poor vision and blinding diseases(3).
According to the University of California, in the study of Nightblind pregnant women randomly assigned to 1 of 6 treatment groups to receive 6 d/wk for 6 wk either 850 microg retinol equivalents/d as retinyl palmitate indicated a significantly increase plasma retinol concentrations in improvement of night vision but do not difference than those who received vitamin A as liver, amaranth leaves,carrots(2).
In support the above, the London School of Hygiene & Tropical Medicine, insisted use of antioxidant vitamin or mineral supplementation such as beta-carotene, vitamin C and vitamin E may delay the progression of age-related macular degeneration disease, but more studies may be necessary to validate these claim(6).

Omega 3 fatty acid found abundantly in flax seed and olive may help improvement of poor vision(4).
Dr. Lawrenson JG and Dr. Evans JR. said, "omega 3 LCPUFA supplementation in people with AMD for periods up to five years does not reduce the risk of progression to advanced AMD or the development of moderate to severe visual loss"(5) of these may be beneficiary to the progression of vision loss of genetic mutation in Conorenal syndrome.
Furthermore, intake of Omega 3 fatty acids also showed to alleviate dry eye symptoms, decrease tear evaporation rate and improve Nelson grade in patients suffering from computer vision syndrome related dry eye(7).

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia. Its phytochemical curcumin is found effectively for treatment of eye disorder(8).
In corneal neovascularization, a leading cause for compromised vision, curcumin significant improven and prevent of corneal neovascularization by suppression in the expression of VEGF controlled by growth factors and cytokines, inflammatory cytokines,,..(9).
The Vision Research Foundation, Sankara Nethralaya study also showed that curcumin suppresses the expression and function of MDR1, the multidrug resistance-associated protein 1(10).

The effectiveness of  Carrot, Olive and Curcumin may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk, complications and treatment of poor vision in Conorenal syndrome with little or no adverse effects.

Senior who are at high risk of poor vision in Conorenal syndrome due to mutation gene should drink no more than 4 servings daily, depending to digestive toleration.

Life style and diet pattern change are necessary.




References
(1) Carrots, carotene and seeing in the dark by Smith W1, Mitchell P, Lazarus R.(PubMed)
(2) Recovery from impaired dark adaptation in nightblind pregnant Nepali women who receive small daily doses of vitamin A as amaranth leaves, carrots, goat liver, vitamin A-fortified rice, or retinyl palmitate By Haskell MJ1, Pandey P, Graham JM, Peerson JM, Shrestha RK, Brown KH.(PubMed)
(3) Dietary 9-cis-β,β-carotene fails to rescue vision in mouse models of leber congenital amaurosis by Maeda T1, Perusek L, Amengual J, Babino D, Palczewski K, von Lintig J.(PubMed)
(4) Omega-3 for your eyes. Research finds DHA may help preserve your vision. [No authors listed](PubMed)
(5) Omega 3 fatty acids for preventing or slowing the progression of age-related macular degeneration by Lawrenson JG1, Evans JR.(PubMed)
(6) Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration by Evans JR1, Lawrenson JG.(PubMed)
(7) Oral omega-3 fatty acids treatment in computer vision syndrome related dry eye by Bhargava R1, Kumar P2, Phogat H3, Kaur A3, Kumar M4.(PubMed)
(8) A New Insight of Herbal Promises Against Ocular Disorders: An Occuloinformatics Approach by Srivastava P1, Tiwari A.(PubMed)
(9) Curcumin nanoparticles inhibit corneal neovascularization by Pradhan N1, Guha R2, Chowdhury S2, Nandi S2, Konar A3, Hazra S4.(PubMed)

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