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Wednesday, June 29, 2016

The Smoothie of Green Tea, Blueberry and Grape for Prevention and Treatment of Mouth (Oral) cancer

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for prevention and treatment of  Mouth (Oral) cancer
Yield: 2 serving (about 8 ounce each)
3/4 cup blueberry
3/4 cup grape
1 cup green tea drink (Make from 4 grams of green tea and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of  Lichen planus has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Recent studies back by renowned institutions, conveyed that green tea(3) may be holding a key for extracting natural ingredient for reduced early onset and treatment of Mouth (Oral) cancer.

Oral cancer is any malignant cell growth in the tissue located in the oral cavity, including the tissue of the lips or the tongue, cheek lining, floor of the mouth, gums (gingiva) and the roof of the mouth (palate).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. According to the First Hospital of Jilin University, green tea extract (GTE) inhibited three human oral squamous carcinoma
cell lines (CAL-27, SCC-25 and KB), through cell cycle arrest in S and G2/M phases(1).Green tea polyphenol, (-)-epigallocatechin-3-gallate, another major phytochemical, not only can induce oxidative stress in oral cancer cells but exerts antioxidant effects in normal cells(2).
Furthermore, in 14 articles with 19 studies comprising 4675 oral cancer cases were included in this meta-analysis, expressed the positive effect of tea consumption in reduced risk on oral cancer, especially in green tea(3).

Pterostilbene and Resveratrol are phytochemicals in the class of Stilbenoids, found abundantly in grapes, blueberries, etc.,... According to the joint study lead by the Rani Durgavati University, pterostilbene may be one of potential therapeutic compounds for treatment of oral cancer(4). In the extensive research of herbal medicines or natural foods during cancer therapy, the Chung Shan Medical University joint study confirmed that pterostilbene caused autophagy and apoptosis in human oral cancer cells via activation of JNK1/2, the T cell differentiation and the cellular apoptosis pathway(5)
Furthermore, the phytochemical also is found to suppress oral cancer cell invasion by inhibiting MMP-2 expression of metastasis(6).

Dr. Yu XD and colleagues at the joint study lead by the Shandong University, said, "resveratrol exhibits inhibitory effect on the proliferation of OSCC oral cancer cells through the induction of apoptosis and G2/M phase cell cycle arrest"(7).
Similarly to Pterostilbene, resveratrol also inhibited MMP-9 expression and oral cancer cell metastasis via down regulated JNK1/2 and ERK1/2(survival and apopotic) signals pathways(8).

The finding of the effectiveness of Green Tea, Blue berry and Grape may serve as cornerstones of pharmaceutical target for further studies as well as a potential medication for treatment of Mouth (Oral) cancer

People who are at increased risk of  Mouth (Oral) cancer due to family history, weaken immunity,....should drink the juices at least one a day. People with Mouth (Oral) cancer should drink the juice as much as  as they can, depending to digestive toleration.
Life style and diet pattern change are recommended.

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References
(1) [Experimental study on anti-tumor effect and mechanism of green tea extract].[Article in Chinese] by Liu XL1, Liu HQ, Li J, Yang L, Zhao X.(PubMed)
(2) Differential prooxidative effects of the green tea polyphenol, (-)-epigallocatechin-3-gallate, in normal and oral cancer cells are related to differences in sirtuin 3 signaling by Tao L1, Park JY, Lambert JD.(PubMed)
(3) Association of tea consumption and the risk of oral cancer: a meta-analysis by Wang W1, Yang Y2, Zhang W3, Wu W4.(PubMed))
(4) Potential Compounds for Oral Cancer Treatment: Resveratrol, Nimbolide, Lovastatin, Bortezomib, Vorinostat, Berberine, Pterostilbene, Deguelin, Andrographolide, and Colchicine. by Bundela S1,2, Sharma A2, Bisen PS1,(PubMed)) 
(5) Pterostilbene induce autophagy on human oral cancer cells through modulation of Akt and mitogen-activated protein kinase pathway by Ko CP1, Lin CW2, Chen MK3, Yang SF4, Chiou HL5, Hsieh MJ6.(PubMed)
(6) Pterostilbene suppresses oral cancer cell invasion by inhibiting MMP-2 expression. by Lin CW1, Chou YE, Chiou HL, Chen MK, Yang WE, Hsieh MJ, Yang SF.(PubMed
(7) Resveratrol inhibits oral squamous cell carcinoma through induction of apoptosis and G2/M phase cell cycle arrest. by Yu XD1,2,3, Yang JL4, Zhang WL2, Liu DX5,6.(PubMed)
(8) Resveratrol suppresses TPA-induced matrix metalloproteinase-9 expression through the inhibition of MAPK pathways in oral cancer cells by Lin FY1,2, Hsieh YH3, Yang SF1,4, Chen CT5,6, Tang CH7,8, Chou MY5,9, Chuang YT1, Lin CW6,9, Chen MK1,10.(PubMed)

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