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Saturday, January 30, 2016

The Holistic Clinical Trials and Studies of Polycystic Ovarian Syndrome: TCM recommended Herbal Cordyceps militaris(Dong Chong Xia cao)) for Spleen Yang deficiency

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                    Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).

                    In Traditional Chinese Medicine Perspective
                               
While conventional medicine focus of using synthetic medication to induce ovulation and assisted artificial insemination for infertility couple, if the medicine fail, traditional Chinese medicine views polycystic ovarian syndrome in different approaches.Polycystic ovary syndrome, according to traditional Chinese medicine is a medical condition characterized by accumulative of fluid over a prolonged period of time causes of dampness and phlegms(247a)(247b) build up on the ovaries due to the effects of vary differentiations, affecting not only the women’s menstrual cycle, but also ovulation and fertility(1247a)(247b).

Dietary Suggestion, Life Style Modification and Nutritional Supplements according to TCM
According to Angela Warburton(1249), a doctor of Traditional Chinese Medicine practicing in Toronto, Canada, incorporating the proper dietary and lifestyle modifications, may make a BIG difference in the long-term for treatment of PCOs(1249).




PCOs Treatment according traditional Chinese medicine

Depending to differentiation, most common diagnosis of polycystic ovary syndrome can be classified into


                               Spleen yang deficiency


Spleen yang deficiency is a serve form of spleen qi deficiency, characterized by a condition of inability of spleen in distribution of fluid and nutrient to the body organs, in removal and descend the turbids(2072), causing malfunctions functions of the organs and fluid retention. Prolong period of spleen yang deficiency may induce the development of phlegm, including women with PCOs.
Women with PCOs diagnosed by spleen yang deficiency may also experience yang vacuity impelled cold expression of additional symptoms of abdominal pain(2074), lack of appetite(2076), fatigue(2075), lightheadedness(2075) and headache(2075), weakness of the four limbs(2077), diarrhea(2073)(2076), chilliness(2077), edema(2074), pale, swollen, wet tongue(2076) and weak, slow, deep pulse(2072),....
In the review of the Data base provided by PubMed, spleen qi deficiency may alter certain metabolic pathways, such as the energy, protein, and glycolytic metabolisms(2078), body weight and motor behavior(2079), skeletal muscle function(3080), blood glucose, lipid metabolism and fat-islet axie.(2081),.....


Herbal Medicine recommended for Treatment of PCOs induced by spleen yang deficiency            

Cordyceps militaris(Dong Chong Xia cao)
Dong chong xia cao, the sweet and warm herb also known as cordyceps sinensis, used in traditional Chinese medicine as immune enhancer(2229)(2230), anti microbial(2231)(2232), anti oxidant(2233)(2234), anti inflammatory(2235)(2236), anti cancer(2237)(2238), cardio-protective(2239)(2240)(2241) agent and for treatment of cirrhosis(2242)(2243), lower back pain (due to it analgesic property)(2244), chronic cough and asthma(2245)(2246), ... as it tonifies yang, nourishes lung yin, transforms phlegm, by enhancing the function of kidney and lung channels(2229).

Phytochemical constituents(2228)
1. Cordyceps polysaccharide
2. Ergosterol
3. Cordycepic acid
4. Amino Acids
5. Lysine
6. Aspartic acid
7. Threonine
8. Taurine
9. Etc.

On metabolic syndrome, in diabetics rat model, Dong chong xia cao inhibited significantly the level of glucose metabolic disorders(2250)(such as hyperglycemia(2251)(2252) by enhancing the glyconeogenesis in serum glucose and lipid profiles(2247), by promoting anti-lipid peroxidation activities and inhibit accumulation of cholesteryl ester in macrophages via suppression of LDL oxidation(2253), regulating the expression of lipoprotein lipase (LPL) and hepatic lipase (HL) activity(2253) and activating protein kinase (AMPK)(2254), improved insulin sensitive(2248)(2249) by inhibiting the activity of human protein tyrosine phosphatase 1B (PTP1B) activity(2249) though metabolism of glucose and lipid(2247)(2248), the microcirculation disturbance(2247)(2248) and the oxidative stress(2247)
On obesity, dong chong xia cao has found to improve the obesity(2255)(2256) through decreased body weight and improved energy uptake(2255) by inhibiting alpha-glycosidase(2255) and adipogenic(2256) and lipid accumulation(2256) activity.
On metabolic syndrome's complications, the herbal medicine reduced risk of diabetes(2259)(2260) and cardiovascular disease(2259) through inhibition of low grade inflammation(2259)(2260) and platelet activation(2263)via immunomodulatory(2259)(2260) and antioxidant activity(2261)(2262).
According to Jenteh Junior College of Medicine and Nursing Management and National Cheng Kung University Medical College, dong chong xia cao improved sex desire(2257), and fertility(2258) through increasing serum testosterone and estradiol-17 (E2) concentrations in production of quality of maturing oocyte, respectively without effecting follicle stimulating hormone (FSH), luteinizing hormone (LH) or prolactin(2257).

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References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women WithPolycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(1246) [Clinical study of area of Jiangsu province of polycystic ovarian syndrome correlation distribution of traditional Chinese medicine syndrome type and improper diet]. [Article in Chinese] by Feng Y, Gao YP.(PubMed)
(1247) [Preliminary study on relationship of disease-syndrome-symptom of ovulatory disorder infertility based on factor analysis]. [Article in Chinese] by Li M, Ma K, Shan, J.(PubMed)
(1247a) A Comprehensive Treatment of Polycystic Ovarian Syndrome (PCOS) bny by Liqin Zhao
(2072) Spleen, Earth
(2073) [Research on building method of spleen kidney Yang deficiency diarrhea rats model]. [Article in Chinese] by Pan X, Hu CJ, Geng YY, Zhao L, Wu WH, Wu XQ, Zhong ZD.(PubMed)
(2074) Treatment of an elderly patient with acute abdominal pain with traditional Korean medicine by Son CG1.(PubMed)
(2075) Shenzhu Tiaopi granule combined with lifestyle intervention therapy for impaired glucose tolerance: a randomized controlled trial by Fang Z1, Zhao J2, Shi G3, Shu Y3, Ni Y3, Wang H3, Ding L3, Lu R3, Li J3, Zhu X3, Cheng S4, Zhang X3, Liu Y5, Wang J6, Luo Y3, Fan Q3, Guo C3, Jiang T3, Wu Q3, Fan L3, Ling H3, Cui L3, Luo Y3, Yang H3, Anderson RM7.(PubMed)
(2075) Direct moxibustion to treat spleen qi and yang deficiency fatigue: a pilot study by Thorne TL1, Hanes DA2, Wild H3, Colbert A4.(PubMed)
(2076) [Clinical observation on fuzhong (supporting the middle-jiao) manipulation of tuina for infantile anorexia]. [Article in Chinese] by Wang YY, Liu XY.(PubMed)
(2077) [Effect of umbilicus moxibustion therapy on physical conditions of yang-deficiency volunteers]. [Article in Chinese] by Zhang YY1.(PubMed)
(2078) Analysis of the restorative effect of Bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model using (1)H-NMR-based metabonomics by Zheng XF1, Tian JS2, Liu P3, Xing J1, Qin XM1.(PubMed)
(2079) [1H NMR based metabolomics study of bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model]. [Article in Chinese] by Chen L, Xiang H, Xing J, Tian JS, Qin XM, Du GH.(PubMed)
(2080) Bufei Jianpi granules improve skeletal muscle and mitochondrial dysfunction in rats with chronic obstructive pulmonary disease by Dong Y1,2, Li Y3,4,5, Sun Y6, Mao J7, Yao F8, Tian Y9, Wang L10, Li L11, Li S12,13,14, Li J15,16,17(PubMed)
(2081) [Clinical observation on obesity and hyperlipidemia of liver qi stagnation and spleen deficiency pattern in female patients treated with combined therapy of acupuncture and tapping method]. [Article in Chinese] by Wu B, Liu ZC, Xu B.(PubMed)
(2228) Dong chong xia cao(Complementary and Alternative Healing University)
(2229) [Effect of cordyceps sinensis on cellular immunity in rats with chronic renal insufficiency]. [Article in Chinese] by Cheng Q1.(PubMed)
(2230) Comparisons on enhancing the immunity of fresh and dry Cordyceps militaris in vivo and in vitro by Zhu SJ1, Pan J, Zhao B, Liang J, Ze-Yu W, Yang JJ.(PubMed)
(2231) Phytochemical and antimicrobial activities of Himalayan Cordyceps sinensis (Berk.) by Sacc. Mamta, Mehrotra S, Amitabh, Kirar V, Vats P, Nandi SP, Negi PS, Misra K.(PubMed)
(2232) Hot-water extract from mycelia of Cordyceps sinensis as a substitute for antibiotic growth promoters by Koh JH1, Suh HJ, Ahn TS.(PubMed)
(2233) Antioxidant activity of the extracts from fruiting bodies of cultured Cordyceps sinensis by Yamaguchi Y1, Kagota S, Nakamura K, Shinozuka K, Kunitomo M.(PubMed)
(2234) Anti-oxidation activity of different types of natural Cordyceps sinensis and cultured Cordyceps mycelia by Li SP1, Li P, Dong TT, Tsim KW.(PubMed)
(2235) Anti-inflammatory principles from Cordyceps sinensis by Yang ML1, Kuo PC, Hwang TL, Wu TS.(PubMed)
(2236) Evaluation of the anti-inflammatory and anti-proliferation tumoral cells activities of Antrodia camphorata, Cordyceps sinensis, and Cinnamomum osmophloeum bark extracts by Rao YK1, Fang SH, Tzeng YM.(PubMed)
(2237) Anti-tumor effect of Cordyceps militaris in HCV-infected human hepatocarcinoma 7.5 cells by Lee S1, Lee HH, Kim J, Jung J, Moon A, Jeong CS, Kang H, Cho H.(PubMed)
(2238) Toxicity evaluation of cordycepin and its delivery system for sustained in vitro anti-lung cancer activity by Aramwit P1, Porasuphatana S2, Srichana T3, Nakpheng T3.(PubMed)
(2239) [Current studies and prospect of anti-thrombotic effect of Cordyceps fungi]. [Article in Chinese] by Li XG1, Xiao JH1.(PubMed)
(2240) Protective effect of extract of Cordyceps sinensis in middle cerebral artery occlusion-induced focal cerebral ischemia in rats by Liu Z1, Li P, Zhao D, Tang H, Guo J.(PubMed)
(2241) Role of dongchongxiacao (Cordyceps) in prevention of contrast-induced nephropathy in patients with stable angina pectoris by Zhao K1, Li Y, Zhang H.(PubMed)
(2242) [Cordyceps mycelia extract decreases portal hypertension in rats with dimethylnitrosamine-induced liver cirrhosis: a study on its histological basis]. [Article in Chinese] by Wang XB1, Liu P, Tang ZP, Li FH, Liu CH, Hu YY, Xu LM.(PubMed)
(2243) [Acting mechanism of Cordyceps mycelia extract for antagonizing hepatic sinusoidal capillarization in rats with dimethylnitrosamine induced liver cirrhosis]. [Article in Chinese] by Wang XB1, Liu P, Tang ZP.(PubMed)
(2244) Anti-inflammatory and antinociceptive effects of cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis by Qian GM1, Pan GF, Guo JY.(PubMed)
(2245) Cordycepin alleviates airway hyperreactivity in a murine model of asthma by attenuating the inflammatory process by Yang X1, Li Y1, He Y1, Li T1, Wang W2, Zhang J3, Wei J4, Deng Y5, Lin R6.(PubMed)
(2246) The extract of Cordyceps sinensis inhibited airway inflammation by blocking NF-κB activity by Chiou YL1, Lin CY.(PubMed)
(2247) [Investigation of compound, compatibility of Rhodiola crenulata, Cordyceps militaris, and Rhum palmatum, on metabolic syndrome treatment VI--improving hyperglycemia-mediated renal damage]. [Article in Chinese] Fu JY1, Zhang XL2, Tian JY2, Huang LW2, Zhang PC3, Ye F2.(PubMed)
(2248) [Investigation of a compound, compatibility of Rhodiola crenulata, Cordyceps militaris, and Rhum palmatum, on metabolic syndrome treatment. IV--Improving liver lipid accumulation]. [Article in Chinese] by Li J1, Zhang XL, Liu YY, Chen L, Tian JY, Han JY, Zhang PC, Ye F.(PubMed)
(2249) [Investigation of a compound, compatibility of Rhodiola crenulata, Cordyceps militaris, and Rheum palmatum, on metabolic syndrome treatment I--improving insulin resistance]. [Article in Chinese] by Li J1, Chen L, Zhang X, Fu J, Han J, Tian J, Zhang P, Ye F.(PubMed)
(2250) [Investigation of a compound, compatibility of Rhodiola crenulata, Cordyceps militaris, and Rheum palmatum, on metabolic syndrome treatment. V--Mechanisms on improving glucose metabolic disorders]. [Article in Chinese] Wang L1, Zhang XL, Li MH, Tian JY, Zhang PC, Ye F.(PubMed)
(2251) Cordycepin from Cordyceps militaris prevents hyperglycemia in alloxan-induced diabetic mice by Ma L1, Zhang S2, Du M3.(PubMed)
(2252) Anti-hyperglycemic activity of natural and fermented Cordyceps sinensis in rats with diabetes induced by nicotinamide and streptozotocin. Lo HC1, Hsu TH, Tu ST, Lin KC.(PubMed)
(2253) Lipid-lowering effect of cordycepin (3'-deoxyadenosine) from Cordyceps militaris on hyperlipidemic hamsters and rats by Gao J1, Lian ZQ, Zhu P, Zhu HB.(PubMed)
(2254) Cordycepin prevents hyperlipidemia in hamsters fed a high-fat diet via activation of AMP-activated protein kinase by Guo P1, Kai Q, Gao J, Lian ZQ, Wu CM, Wu CA, Zhu HB.(PubMed)
(2255) [Investigation of a compound, compatibility of Rhodiola crenulata, Cordyceps militaris, and Rheum palmatum, on metabolic syndrome treatment II - improving obesity]. [Article in Chinese] by Tian JY1, Chen L, Zhang XL, Li J, Han J, Fu JY, Yang XM, Zhang PC, Ye F.(PubMed)
(2256) Blockade of adipocyte differentiation by cordycepin. Takahashi S1, Tamai M, Nakajima S, Kato H, Johno H, Nakamura T, Kitamura M.(PubMed)
(2257) Effect of Cordyceps militaris supplementation on sperm production, sperm motility and hormones in Sprague-Dawley rats by Chang Y1, Jeng KC, Huang KF, Lee YC, Hou CW, Chen KH, Cheng FY, Liao JW, Chen YS.(PubMed)
(2258) Upregulation of steroidogenic enzymes and ovarian 17beta-estradiol in human granulosa-lutein cells by Cordyceps sinensis mycelium by Huang BM1, Hsiao KY, Chuang PC, Wu MH, Pan HA, Tsai SJ.(PubMed)
(2259) Role of Cordycepin and Adenosine on the Phenotypic Switch of Macrophages via Induced Anti-inflammatory Cytokines by Shin S1, Moon S, Park Y, Kwon J, Lee S, Lee CK, Cho K, Ha NJ, Kim K.(PubMed)
(2260) Cordycepin Suppresses Expression of Diabetes Regulating Genes by Inhibition of Lipopolysaccharide-induced Inflammation in Macrophages by Shin S1, Lee S, Kwon J, Moon S, Lee S, Lee CK, Cho K, Ha NJ, Kim K.(PubMed)
(2261) Cardiovascular protection and antioxidant activity of the extracts from the mycelia of Cordyceps sinensis act partially via adenosine receptors by Yan XF1, Zhang ZM, Yao HY, Guan Y, Zhu JP, Zhang LH, Jia YL, Wang RW.(PubMed)
(2262) Protective effect of extract of Cordyceps sinensis in middle cerebral artery occlusion-induced focal cerebral ischemia in rats by Liu Z1, Li P, Zhao D, Tang H, Guo J.(PubMed)
(2263) , inhibit Inhibitory Mechanisms of CME-1, a Novel Polysaccharide from the Mycelia of Cordyceps sinensis, in Platelet Activation by Chang YI, Hsu WH, Lu WJ, Jayakumar T, Liao JC, Lin MJ, Wang SH, Geraldine P, Lin KH, Sheu JR1.(PubMed)

The Holistic Clinical Trials and Studies of Polycystic Ovarian Syndrome: TCM recommended Herbal Licorice (Gancao) for Spleen Yang deficiency

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                    Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).

                    In Traditional Chinese Medicine Perspective
                               
While conventional medicine focus of using synthetic medication to induce ovulation and assisted artificial insemination for infertility couple, if the medicine fail, traditional Chinese medicine views polycystic ovarian syndrome in different approaches.Polycystic ovary syndrome, according to traditional Chinese medicine is a medical condition characterized by accumulative of fluid over a prolonged period of time causes of dampness and phlegms(247a)(247b) build up on the ovaries due to the effects of vary differentiations, affecting not only the women’s menstrual cycle, but also ovulation and fertility(1247a)(247b).

Dietary Suggestion, Life Style Modification and Nutritional Supplements according to TCM
According to Angela Warburton(1249), a doctor of Traditional Chinese Medicine practicing in Toronto, Canada, incorporating the proper dietary and lifestyle modifications, may make a BIG difference in the long-term for treatment of PCOs(1249).




PCOs Treatment according traditional Chinese medicine

Depending to differentiation, most common diagnosis of polycystic ovary syndrome can be classified into


                               Spleen yang deficiency


Spleen yang deficiency is a serve form of spleen qi deficiency, characterized by a condition of inability of spleen in distribution of fluid and nutrient to the body organs, in removal and descend the turbids(2072), causing malfunctions functions of the organs and fluid retention. Prolong period of spleen yang deficiency may induce the development of phlegm, including women with PCOs.
Women with PCOs diagnosed by spleen yang deficiency may also experience yang vacuity impelled cold expression of additional symptoms of abdominal pain(2074), lack of appetite(2076), fatigue(2075), lightheadedness(2075) and headache(2075), weakness of the four limbs(2077), diarrhea(2073)(2076), chilliness(2077), edema(2074), pale, swollen, wet tongue(2076) and weak, slow, deep pulse(2072),....
In the review of the Data base provided by PubMed, spleen qi deficiency may alter certain metabolic pathways, such as the energy, protein, and glycolytic metabolisms(2078), body weight and motor behavior(2079), skeletal muscle function(3080), blood glucose, lipid metabolism and fat-islet axie.(2081),.....




Herbal Medicine recommended for Treatment of PCOs induced by spleen yang deficiency

 Licorice (gancao)
(See stress management in herbal medicine for more information)
[Gan Cao is also known as Licorice root. The sweet and neutral herb has been used in TCM as anti allergy(856), anti inflammation(855), anti ulcer(857), anti convulsion(858) agent and to treat stomach weakness, tired and lack of strength, cough with abundance of phlegm, stomach and solar plexus pain, and improve cardiac function(855), etc., as it tonifies the Spleen, benefits the Qi, moistens the Lungs, calms cough, deaf or acute pain, by enhancing all 12 channels(859).In treatment of PCOs(862), combination of licorice and 100 mg spironolactone showed the activation of the renin-aldosterone system in lowering blood pressure and water (fluid) balance(860). reducing the prevalence of side effects related to the diuretic activity of spironolactone(860). In model rats experiment, Ganshao Paste (CGP), showed the decrease of serum levels of LH, T, and FSH and increase of serum estradiol (E2), and progesterone (P)(861)(865)].

(See The Insulin resistance improvement and/or anti metabolic syndrome herbs: Licorice for more information)
1. PCOs
[ Licorice, in a review of 33 studies of herbal medicine for the management of polycystic ovary syndrome (PCOS), showed a strong evidence in improved metabolic hormone profile and improved fertility outcomes and regulation of ovulation and inhibition of hyperandrogenism in PCOS(860). In model rats experiment, Ganshao Paste (CGP), also decreased serum levels of LH, T, and FSH and increased of serum estradiol (E2), and progesterone (P)(861)(860)(865). According to University of Natural Resources and Life Sciences Vienna, licorice may have a potential effect on metabolic syndrome(862) in women with PCOs.

2. Blow flow
Licorice improves the blood flow in the body by exerting its anti thrombosis(983) and inhibiting the levels of bad cholesterol(984)(985) and triglyceride levels(985) and increasing HDL-cholesterol content(984) in reduced risk of cardiovascular disease(985) and blood stagnation(897) in the abdominal region induced induced infertility(986).

3. Glycyrrhizin
Glycyrrhizin, one of main ingredient from licorice, exhibited anti inflammatory effect pharmacologically in treatment of inflammatory diseases(988)(989)(990), lowered high serum testosterone levels in oligomenorrheic or amenorrheic women, and induced conception in some women(991). As antioxidant, the phytochemical also inhibit irregular cell growth(992)(993) and microbial invasion(994)(995) causes of cancers(992)(993) and infection and inflammation(994)(995) respectively. in adrenocortical function and behavour, it also regulated the levels of cortisol(996), induced by over production of serotonin cause of hormone imbalance(997).

4. Phytoestrogen
See phytoestrogen in black cohosh
[Phytoestrogen found it balck cohosh showed to occupy the estrogen receptor sites in women body(908), through it antiestrogenic and extrogenic effects(909), to induce hormone balancing may result in improving the chance of ovulation and fertility(910)(911)].

5. Lecithin
Lecithin is a fat like substance called a phospholipid improved lipid transfer, cholesterol efflux, HDL genesis and and remodeling at the blood-brain barrier (BBB)(998). against cells from oxidation surrounding the brain(999), in reducing psychotic symptoms(1002) such as stress(1000)(1001), and depression(1002).
Side effects
1. It may raise blood pressure(1003)(1004(1006)
2. Long term usage of large dosage can also cause edema(1004)(1006) and hypokalemia(1004)(1005)(1006).
3. Overdose can be toxic(106), in inducing rhabdomyolysis or myoglobinuria(1006).
4. Etc.]

Phytochemicals(1058)
1. Glycyrrhizic acid
2. Licochalcone A
3. Licochalcone B
4. Licoflavone
5. Liquiritin
5. Liquiritigenin
7. Isoliquiritigenin
8. Ononins
9. 4′,7-dihydroxyflavone
10. Glycyrrhetinic acid
11. 11-deoxyglycyrrhetinic acid
12. β-sitosterol
13. Etc.

Licorice's phytochemicals, especially glycyrrhizin, have shown efffectively in ameliorated insulin resistance(1059)(1061)(1063)(1064), hyperglycemia(1059)(1060), dyslipidemia(1059)(1063) and oxidative stress(1064) in fructose-induced metabolic syndrome(1059)(1061)(1063) in animal(1059)(1060)(1061)models, probably through its interference of the development of visceral obesity(1064) and cellular derailments that are responsible for the development of metabolic syndrome(1062), anti inflammatory(1062), antioxidant(1062) and an associated with a decrease in tissue lipid deposition(1063) effects].

In chronic unpredictable stress rat model, total flavonoids extract(1153) (licorice flavonoids, LF) and liquiritin(1154), a phyochemical found in locorice exerted anti-depressive(1153)(1154)(1155) and anti-cognitive impairment(1156) property through total flavonoids extract neurogenesis protective effect(1153) and defense of liquiritin and flavonoids extract against oxidative stress(1154)(1156).
Yokukansan, a traditional Japanese formula, containing licorice showed effectively in amelioration of behavioral symptoms, such as aggressiveness, excitability, and hallucination, through reduced stress increased the serotonin 2A (5-HT2A) receptors density on the plasma membrane of the prefrontal cortex (PFC)(1158).
In high-glucose stress, Glabridin(1159)(1160), an isoflavan from licorice root reduced high-glucose stress(1159)(1160) through its anti inflammatory activity(1159), up-regulates manganese superoxide dismutase, catalase and paraoxonase 2(1160).
In anti oxidative stress, licorice showed to contribute to their overall health promoting pharmacological effects against free radicals(1161)(1162)(1163)(1164) induced diseases such as cancer(1161), cardiac dysfunction(1162) liver disease(1164), etc., through its anti-inflammatory(1161)(1163)(1164), anti-oxidant activities(1161)(1162)(1163)(1164).
According to University of Western Sydney, Glycyrrhiza glabra, one of Chinese herbs, exhibited strong evidences of neuroprotective activity for promotion of healthy ageing and longevity(1157).]
According to studies, licorice also is effective in preventing and ameliorating diabetes(2122)(2124), abdominal obesity(2122)(2123) in rat model study.
On metabolic syndrome's complication of cardiovascular disease, licorice and its phytochemicals exerted cardioprotective effect(2127) in prevention of incidence of fatal ventricular arrhythmia from ischemia/reperfusion injury(2125), myocardial infarction(2126) by amelioration of oxidative stress and modulation of cardiac function(2126).

Made From Fresh Fruits And Vegetable Recipes
Secret To A Vibrant And Healthy Lifestyle
That You Can Find Easily At The Comfort Of Your Kitchen.

All Forms of Arthritis are Curable

You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html
References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women WithPolycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(1246) [Clinical study of area of Jiangsu province of polycystic ovarian syndrome correlation distribution of traditional Chinese medicine syndrome type and improper diet]. [Article in Chinese] by Feng Y, Gao YP.(PubMed)
(1247) [Preliminary study on relationship of disease-syndrome-symptom of ovulatory disorder infertility based on factor analysis]. [Article in Chinese] by Li M, Ma K, Shan, J.(PubMed)
(1247a) A Comprehensive Treatment of Polycystic Ovarian Syndrome (PCOS) bny by Liqin Zhao
(2072) Spleen, Earth
(2073) [Research on building method of spleen kidney Yang deficiency diarrhea rats model]. [Article in Chinese] by Pan X, Hu CJ, Geng YY, Zhao L, Wu WH, Wu XQ, Zhong ZD.(PubMed)
(2074) Treatment of an elderly patient with acute abdominal pain with traditional Korean medicine by Son CG1.(PubMed)
(2075) Shenzhu Tiaopi granule combined with lifestyle intervention therapy for impaired glucose tolerance: a randomized controlled trial by Fang Z1, Zhao J2, Shi G3, Shu Y3, Ni Y3, Wang H3, Ding L3, Lu R3, Li J3, Zhu X3, Cheng S4, Zhang X3, Liu Y5, Wang J6, Luo Y3, Fan Q3, Guo C3, Jiang T3, Wu Q3, Fan L3, Ling H3, Cui L3, Luo Y3, Yang H3, Anderson RM7.(PubMed)
(2075) Direct moxibustion to treat spleen qi and yang deficiency fatigue: a pilot study by Thorne TL1, Hanes DA2, Wild H3, Colbert A4.(PubMed)
(2076) [Clinical observation on fuzhong (supporting the middle-jiao) manipulation of tuina for infantile anorexia]. [Article in Chinese] by Wang YY, Liu XY.(PubMed)
(2077) [Effect of umbilicus moxibustion therapy on physical conditions of yang-deficiency volunteers]. [Article in Chinese] by Zhang YY1.(PubMed)
(2078) Analysis of the restorative effect of Bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model using (1)H-NMR-based metabonomics by Zheng XF1, Tian JS2, Liu P3, Xing J1, Qin XM1.(PubMed)
(2079) [1H NMR based metabolomics study of bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model]. [Article in Chinese] by Chen L, Xiang H, Xing J, Tian JS, Qin XM, Du GH.(PubMed)
(2080) Bufei Jianpi granules improve skeletal muscle and mitochondrial dysfunction in rats with chronic obstructive pulmonary disease by Dong Y1,2, Li Y3,4,5, Sun Y6, Mao J7, Yao F8, Tian Y9, Wang L10, Li L11, Li S12,13,14, Li J15,16,17(PubMed)
(2081) [Clinical observation on obesity and hyperlipidemia of liver qi stagnation and spleen deficiency pattern in female patients treated with combined therapy of acupuncture and tapping method]. [Article in Chinese] by Wu B, Liu ZC, Xu B.(PubMed)

(2122) A licorice ethanolic extract with peroxisome proliferator-activated receptor-gamma ligand-binding activity affects diabetes in KK-Ay mice, abdominal obesity in diet-induced obese C57BL mice and hypertension in spontaneously hypertensive rats by Mae T1, Kishida H, Nishiyama T, Tsukagawa M, Konishi E, Kuroda M, Mimaki Y, Sashida Y, Takahashi K, Kawada T, Nakagawa K, Kitahara M.(PubMed)
(2123) 18β-glycyrrhetinic acid attenuates anandamide-induced adiposity and high-fat diet induced obesity by Park M1, Lee JH, Choi JK, Hong YD, Bae IH, Lim KM, Park YH, Ha H.(PubMed)
(2124) Effect of licorice extract on the complications of diabetes nephropathy in rats by Kataya HH1, Hamza AA, Ramadan GA, Khasawneh MA.(PubMed)
(2125) Glycyrrhetinic Acid protects the heart from ischemia/reperfusion injury by attenuating the susceptibility and incidence of fatal ventricular arrhythmia during the reperfusion period in the rat hearts by Wu HJ1, Yang JY, Jin M, Wang SQ, Wu DL, Liu YN, Yan X, Yang C, Zhang G, He J.(PubMed)
(2126) Glycyrrhiza glabra protects from myocardial ischemia-reperfusion injury by improving hemodynamic, biochemical, histopathological and ventricular function by Ojha S1, Golechha M, Kumari S, Bhatia J, Arya DS.(PubMed)
(2127) A Review: The Pharmacology of Isoliquiritigenin by Peng F1, Du Q, Peng C, Wang N, Tang H, Xie X, Shen J, Chen J.(PubMed)

Friday, January 29, 2016

The Smoothie Ginger, Turmeric and Tomatoes for Prevention and Treatment of Premenstrual syndrome(PMS)

Kyle J. Norton(Scholar and Master of Nutrients) all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


The smoothie for prevention and treatment of women with premenstrual syndrome
Yield: 2 servings (about 8 ounces each)
1 1/2 cups tomatoes
1 large slice of ginger
1 tsp of curcumin
1 cup of rice milk


1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredient for prevention and treatment of premenstrual syndrome to replace the adverse effects of conventional medicine has been facing many obstacles. Many initially potentially therapeutic values working in animal studies does not produce the same effectiveness in human trials.

Scientists in some well known institution may have found the combination of ingredients of ginger(1), curcumin(3) and tomato(7) with therapeutic values for reduced painful symptoms and treatment of premenstrual syndrome, recent studies suggested.

Premenstrual syndrome effects over 70% to 90% of women in the US and less for women in Southeast Asia because of their difference in living style and social structure. It is defined as faulty function of the ovaries related to the women's menstrual cycle, it effects a women's physical and emotional state, and sometimes interferes with daily activities as a result of hormone fluctuation. The syndrome occurs one to two weeks before menstruation and then declines when the period starts.

Ginger (Zingiber officinale) or ginger root is the genus Zingiber, belongings to the family Zingiberaceae, native to Tamil, used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
The use of ginger for treatment of pain, including PMS may be resulted of its anti-inflammatory constituents, according to the review of data base of studies(2).According to the joint study lead by the Zahedan University of Medical Sciences, in a a clinical trial, double-blinded work, and participants randomly allocated, intake of 2 ginger capsules daily from seven days before menstruation to three days after menstruation for three cycles, significantly reduced severity of the symptoms by daily record scale in woman with PMS(1).

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia, used in trditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc. Its phytochemical curcumin has showed to exhibit anti PMS effect, through mediating enhancing serum BDNF levels, a biological marker for depressive state(3)In a a clinical trial, double-blinded study of women suffering from PMS, through modulation of neurotransmitters and anti-inflammatory effects, curcumin attenuated severity of PMS symptoms such as improvement of psychological, physical and behavioral changes(4).

Tomato is a red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, tomato is grown world wide for commercial purpose
and often in green house. its steroidal glycosides isolated from the ripe fruit of the cherry tomato(6) was found effectively in treatment of symptoms of PMS in women through the effect of metabolization of steroidal hormone in exhibiting various physiological activities(5).
Carotenoids, another major constituent found in tomato, may also associate with symptoms of premenstrual syndrome (PMS). According to the University of Texas Medical Branch, women with PMS have hound to strongly related to deficiency of vitamin A(7).

Dietary supplement "Karinat" which contains beta-carotene 2.5 mg, alpha-tocopherol 5 mg, ascorbic acid 30 mg and garlic powder 150 mg per one tablet, effectively reduced the severity of mastalgia, premenstrual syndrome, dysmenorrhea and algomenorrhea and caused regression of palpable symptoms of the breast fibromatosis, according to Dr. Bespalov VG, and colleagies(8).


Taking altogether, women who are at increased risk of PMS due to menstrual irregularity, obesity,.... .....should drink at least one serving daily and women with PMS should drink the smoothie as much as they can, depending to digestive toleration.
Change of life style and diet pattern are also recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca







References
(1) Effect of treatment with ginger on the severity of premenstrual syndrome symptoms by Khayat S1, Kheirkhah M2, Behboodi Moghadam Z3, Fanaei H4, Kasaeian A5, Javadimehr M6.(PubMed)
(2) The use of ginger (Zingiber officinale) for the treatment of pain: a systematic review of clinical trials by Terry R1, Posadzki P, Watson LK, Ernst E.(PubMed)
(3) Effect of curcumin on serum brain-derived neurotrophic factor levels in women with premenstrual syndrome: A randomized, double-blind, placebo-controlled trial by Fanaei H1, Khayat S2, Kasaeian A3, Javadimehr M4.(PubMed)
(4) Curcumin attenuates severity of premenstrual syndrome symptoms: A randomized, double-blind, placebo-controlled trial by Khayat S1, Fanaei H2, Kheirkhah M3, Moghadam ZB4, Kasaeian A5, Javadimehr M6.(PubMed)
(5) Metabolism of tomato steroidal glycosides in humans by Noguchi E1, Fujiwara Y, Matsushita S, Ikeda T, Ono M, Nohara T.(PubMed)
(6) A new steroidal glycoside and a new phenyl glycoside from a ripe cherry tomato by Ono M1, Shiono Y, Yanai Y, Fujiwara Y, Ikeda T, Nohara T.(PubMed)
(7) Vitamin A levels in premenstrual syndrome by Chuong CJ1, Dawson EB, Smith ER.(PubMed)
(8) [Study of an antioxidant dietary supplement "Karinat" in patients with benign breast disease].[Article in Russian] by Bespalov VG, Barash NIu, Ivanova OA, Krzhivitskiĭ PI, Semiglazov VF, Aleksandrov VA, Sobenin NA, Orekhov AN.(PubMed)

Thursday, January 28, 2016

The Holistic Clinical Trials and Studies of Polycystic Ovarian Syndrome: TCM recommended Foods for Spleen Yang deficiency - Pomegranates

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                    Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).

                    In Traditional Chinese Medicine Perspective
                               
While conventional medicine focus of using synthetic medication to induce ovulation and assisted artificial insemination for infertility couple, if the medicine fail, traditional Chinese medicine views polycystic ovarian syndrome in different approaches.Polycystic ovary syndrome, according to traditional Chinese medicine is a medical condition characterized by accumulative of fluid over a prolonged period of time causes of dampness and phlegms(247a)(247b) build up on the ovaries due to the effects of vary differentiations, affecting not only the women’s menstrual cycle, but also ovulation and fertility(1247a)(247b).

Dietary Suggestion, Life Style Modification and Nutritional Supplements according to TCM
According to Angela Warburton(1249), a doctor of Traditional Chinese Medicine practicing in Toronto, Canada, incorporating the proper dietary and lifestyle modifications, may make a BIG difference in the long-term for treatment of PCOs(1249).




PCOs Treatment according traditional Chinese medicine

Depending to differentiation, most common diagnosis of polycystic ovary syndrome can be classified into


                               Spleen yang deficiency


Spleen yang deficiency is a serve form of spleen qi deficiency, characterized by a condition of inability of spleen in distribution of fluid and nutrient to the body organs, in removal and descend the turbids(2072), causing malfunctions functions of the organs and fluid retention. Prolong period of spleen yang deficiency may induce the development of phlegm, including women with PCOs.
Women with PCOs diagnosed by spleen yang deficiency may also experience yang vacuity impelled cold expression of additional symptoms of abdominal pain(2074), lack of appetite(2076), fatigue(2075), lightheadedness(2075) and headache(2075), weakness of the four limbs(2077), diarrhea(2073)(2076), chilliness(2077), edema(2074), pale, swollen, wet tongue(2076) and weak, slow, deep pulse(2072),....
In the review of the Data base provided by PubMed, spleen qi deficiency may alter certain metabolic pathways, such as the energy, protein, and glycolytic metabolisms(2078), body weight and motor behavior(2079), skeletal muscle function(3080), blood glucose, lipid metabolism and fat-islet axie.(2081),.....


                      Foods for Spleen yang deficiency

Spleen yang deficiency can be managed and treated in part with a diet of fresh and cooked warming foods.

9. Pomegranates
Pomegranate is a fruit-bearing small tree, genus Punica, belonging to family Lythraceae, native to Iran, cultivated in Asian since ancient time. The peel has been used in traditional Chinese medicine as anti cancer(2192)(2193)(2194), anti microbial(2192)(2195), neuroprotective(2196)(2197), antioxidant(2192)(2193) and anti inflammatory(2192)(2194) agents and to treatment of abdomen pain(2198)(2199). chronic myeloid leukemia(2191), occidiosis(2200) and helminthosis(2200), ...... by enhancing the function of large intestine(2190).

Phytochemical constituents(2190)
1. Granatin
2. Punicalin
3. Punicalagin
4. Elaidic aicd
5. Cyanidin-3-glucoside
6. cyanindin-3
7. 5-diglucosede
8. Pelargonidin-3-glucoside
9. pelargonidin-3
10. 5-diglucoside
11. Tetrameric gallic acid(2190)
12. Isoquercetrin
13. Ellagitannins
14. Flavonoids,
16. Anthocyanidins
17. Anthocyanins
18. Estrogenic flavonols
20. Flavones(21))
21. Eic.

According to the data base of PubMed, pomegranate (Punica granatum) also exhibited anti metabolic syndrome(2201)(2202) and reduced risk of complications of diabetes(2203)(2204) and cardiovascular disease through the effects on weigh gain(2203), obesity(2207)(2208), fasting blood sugar(2204)(2205)(2206), lipid profiles(2204), lipoprotein oxidation(2204), hypertension(2210)(2211), insulin resistance(2205)(2206)(2207), pancreatic islets(2205), hyperglycemia(2205), hyperlipidedmia(2209)(2211),........via antioxidant(2192)(2193) and anti inflammatory(2192)(2194) pathways.

Made From Fresh Fruits And Vegetable Recipes
Secret To A Vibrant And Healthy Lifestyle
That You Can Find Easily At The Comfort Of Your Kitchen.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women WithPolycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(1246) [Clinical study of area of Jiangsu province of polycystic ovarian syndrome correlation distribution of traditional Chinese medicine syndrome type and improper diet]. [Article in Chinese] by Feng Y, Gao YP.(PubMed)
(1247) [Preliminary study on relationship of disease-syndrome-symptom of ovulatory disorder infertility based on factor analysis]. [Article in Chinese] by Li M, Ma K, Shan, J.(PubMed)
(1247a) A Comprehensive Treatment of Polycystic Ovarian Syndrome (PCOS) bny by Liqin Zhao
(2072) Spleen, Earth
(2073) [Research on building method of spleen kidney Yang deficiency diarrhea rats model]. [Article in Chinese] by Pan X, Hu CJ, Geng YY, Zhao L, Wu WH, Wu XQ, Zhong ZD.(PubMed)
(2074) Treatment of an elderly patient with acute abdominal pain with traditional Korean medicine by Son CG1.(PubMed)
(2075) Shenzhu Tiaopi granule combined with lifestyle intervention therapy for impaired glucose tolerance: a randomized controlled trial by Fang Z1, Zhao J2, Shi G3, Shu Y3, Ni Y3, Wang H3, Ding L3, Lu R3, Li J3, Zhu X3, Cheng S4, Zhang X3, Liu Y5, Wang J6, Luo Y3, Fan Q3, Guo C3, Jiang T3, Wu Q3, Fan L3, Ling H3, Cui L3, Luo Y3, Yang H3, Anderson RM7.(PubMed)
(2075) Direct moxibustion to treat spleen qi and yang deficiency fatigue: a pilot study by Thorne TL1, Hanes DA2, Wild H3, Colbert A4.(PubMed)
(2076) [Clinical observation on fuzhong (supporting the middle-jiao) manipulation of tuina for infantile anorexia]. [Article in Chinese] by Wang YY, Liu XY.(PubMed)
(2077) [Effect of umbilicus moxibustion therapy on physical conditions of yang-deficiency volunteers]. [Article in Chinese] by Zhang YY1.(PubMed)
(2078) Analysis of the restorative effect of Bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model using (1)H-NMR-based metabonomics by Zheng XF1, Tian JS2, Liu P3, Xing J1, Qin XM1.(PubMed)
(2079) [1H NMR based metabolomics study of bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model]. [Article in Chinese] by Chen L, Xiang H, Xing J, Tian JS, Qin XM, Du GH.(PubMed)
(2080) Bufei Jianpi granules improve skeletal muscle and mitochondrial dysfunction in rats with chronic obstructive pulmonary disease by Dong Y1,2, Li Y3,4,5, Sun Y6, Mao J7, Yao F8, Tian Y9, Wang L10, Li L11, Li S12,13,14, Li J15,16,17(PubMed)
(2081) [Clinical observation on obesity and hyperlipidemia of liver qi stagnation and spleen deficiency pattern in female patients treated with combined therapy of acupuncture and tapping method]. [Article in Chinese] by Wu B, Liu ZC, Xu B.(PubMed)
((2190) Fan shi liu(Complementary and Alternative Healing University)
(2191) Growth inhibitory effects of crude pomegranate peel extract on chronic myeloid leukemia, K562 cells by Asmaa MJ1, Ali AJ1, Farid JM1, Azman S2.(PubMed)
(2192) The anti-biofilm potential of pomegranate (Punica granatum L.) extract against human bacterial and fungal pathogens by Bakkiyaraj D1, Nandhini JR, Malathy B, Pandian SK.(PubMed)
(2193) The antioxidant potency of Punica granatum L. Fruit peel reduces cell proliferation and induces apoptosis on breast cancer by Dikmen M1, Ozturk N, Ozturk Y.(PubMed)
(2194) Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer by Lansky EP1, Newman RA.(PubMed)
(2195) Antimicrobial and free radical scavenging activities of five Palestinian medicinal plants by Qabaha KI1.(PubMed)
(2196) Pomegranate from Oman Alleviates the Brain Oxidative Damage in Transgenic Mouse Model of Alzheimer's disease by Subash S1, Essa MM2, Al-Asmi A3, Al-Adawi S3, Vaishnav R4, Braidy N5, Manivasagam T6, Guillemin GJ7.(PubMed)
(2197) Pomegranate extract modulates processing of amyloid-β precursor protein in an aged Alzheimer's disease animal model by Ahmed AH, Subaiea GM, Eid A, Li L, Seeram NP, Zawia NH1.(PubMed)
(2198) Antinociceptive and anti-inflammatory activities of a pomegranate (Punica granatum L.) extract rich in ellagitannins by González-Trujano ME1, Pellicer F, Mena P, Moreno DA, García-Viguera C.(PubMed)
(2199) Topical anti-inflammatory and analgesic activities of standardized pomegranate rind extract in comparison with its marker compound ellagic acid in vivo by Mo J1, Panichayupakaranant P, Kaewnopparat N, Nitiruangjaras A, Reanmongkol W.(PubMed)
(2200) Anti-coccidial, anthelmintic and antioxidant activities of pomegranate (Punica granatum) peel extract by Dkhil MA1.(PubMed)
(2201) Pomegranate: a fruit that ameliorates metabolic syndrome by Medjakovic S1, Jungbauer A.(PubMed)
(2202) Acute and long term effects of grape and pomegranate juice consumption on endothelial dysfunction in pediatric metabolic syndrome by Kelishadi R1, Gidding SS, Hashemi M, Hashemipour M, Zakerameli A, Poursafa P.(PubMed)
(2203) Pomegranate seed oil consumption during a period of high-fat feeding reduces weight gain and reduces type 2 diabetes risk in CD-1 mice by McFarlin BK1, Strohacker KA, Kueht ML.(PubMed)
(2204) Effect of pomegranate juice on paraoxonase enzyme activity in patients with type 2 diabetes by Parsaeyan N1, Mozaffari-Khosravi H, Mozayan MR.(PubMed)
(2205) Extracts of black bean peel and pomegranate peel ameliorate oxidative stress-induced hyperglycemia in mice by Wang JY1, Zhu C1, Qian TW1, Guo H1, Wang DD1, Zhang F1, Yin X1.(PubMed)
(2206) Fresh pomegranate juice ameliorates insulin resistance, enhances β-cell function, and decreases fasting serum glucose in type 2 diabetic patients by Banihani SA1, Makahleh SM2, El-Akawi Z3, Al-Fashtaki RA2, Khabour OF4, Gharibeh MY2, Saadah NA5, Al-Hashimi FH2, Al-Khasieb NJ3.(PubMed)
(2207) Preventive and prophylactic mechanisms of action of pomegranate bioactive constituents by Viladomiu M1, Hontecillas R, Lu P, Bassaganya-Riera J.(PubMed)
(2208) Obesity: the preventive role of the pomegranate (Punica granatum) by Al-Muammar MN1, Khan F.(PubMed)
(2209) Pomegranate extract (POMx) decreases the atherogenicity of serum and of human monocyte-derived macrophages (HMDM) in simvastatin-treated hypercholesterolemic patients: a double-blinded, placebo-controlled, randomized, prospective pilot study by Hamoud S1, Hayek T2, Volkova N3, Attias J4, Moscoviz D1, Rosenblat M3, Aviram M5.(PubMed)
(2210) Acute effects of pomegranate extract on postprandial lipaemia, vascular function and blood pressure by Mathew AS1, Capel-Williams GM, Berry SE, Hall WL.(PubMed)
(2211) Clinical evaluation of blood pressure lowering, endothelial function improving, hypolipidemic and anti-inflammatory effects of pomegranate juice in hypertensive subjects by Asgary S1, Sahebkar A, Afshani MR, Keshvari M, Haghjooyjavanmard S, Rafieian-Kopaei M.(PubMed)

Wednesday, January 27, 2016

The Holistic Clinical Trials and Studies of Polycystic Ovarian Syndrome: TCM recommended Foods for Spleen Yang deficiency - Black Pepper

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                    Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).

                    In Traditional Chinese Medicine Perspective
                               
While conventional medicine focus of using synthetic medication to induce ovulation and assisted artificial insemination for infertility couple, if the medicine fail, traditional Chinese medicine views polycystic ovarian syndrome in different approaches.Polycystic ovary syndrome, according to traditional Chinese medicine is a medical condition characterized by accumulative of fluid over a prolonged period of time causes of dampness and phlegms(247a)(247b) build up on the ovaries due to the effects of vary differentiations, affecting not only the women’s menstrual cycle, but also ovulation and fertility(1247a)(247b).

Dietary Suggestion, Life Style Modification and Nutritional Supplements according to TCM
According to Angela Warburton(1249), a doctor of Traditional Chinese Medicine practicing in Toronto, Canada, incorporating the proper dietary and lifestyle modifications, may make a BIG difference in the long-term for treatment of PCOs(1249).




PCOs Treatment according traditional Chinese medicine

Depending to differentiation, most common diagnosis of polycystic ovary syndrome can be classified into


                               Spleen yang deficiency


Spleen yang deficiency is a serve form of spleen qi deficiency, characterized by a condition of inability of spleen in distribution of fluid and nutrient to the body organs, in removal and descend the turbids(2072), causing malfunctions functions of the organs and fluid retention. Prolong period of spleen yang deficiency may induce the development of phlegm, including women with PCOs.
Women with PCOs diagnosed by spleen yang deficiency may also experience yang vacuity impelled cold expression of additional symptoms of abdominal pain(2074), lack of appetite(2076), fatigue(2075), lightheadedness(2075) and headache(2075), weakness of the four limbs(2077), diarrhea(2073)(2076), chilliness(2077), edema(2074), pale, swollen, wet tongue(2076) and weak, slow, deep pulse(2072),....
In the review of the Data base provided by PubMed, spleen qi deficiency may alter certain metabolic pathways, such as the energy, protein, and glycolytic metabolisms(2078), body weight and motor behavior(2079), skeletal muscle function(3080), blood glucose, lipid metabolism and fat-islet axie.(2081),.....


                      Foods for Spleen yang deficiency

Spleen yang deficiency can be managed and treated in part with a diet of fresh and cooked warming foods.

8. Black pepper
Black pepper is a flowering vine in the family Piperaceae, cultivated for its fruit, which is usually dried and used as a spice and seasoning. According to traditional Chinese medicine, black pepper has been used as anti-platelet(2173) anti cancer(2174)(2175)(2176), antioxidant(2175)(2176). anti inflammatory(2176)(2173), antispasmodic(2177)(2178), laxative(2178) advocate and to improve blood circulation(2179) through lowering blood pressure and inhibition of high K+ precontractions and treat gastrointestinal disorders(2178) including constipation, diarrhea and abdominal pain........., as it enhances the large intestine and stomach channels.

Phytochemical constituents(2180)
1. Piperine and piperitone
2. Sabinene
3. Beta-pinene
4. Limonene
5. Terpinene
6. Alpha-pinene, myrcene
7. Delta3-carene
8. Monoterpene derivatives
9. Sesquiterpene
10. Beta-caryophyllene
11. Humulene
12. Beta-bisabolone
13. Caryophyllene oxide
14. Phenylether
15. Etc.

Piperine, the major chemical compound found in black paper has exhibited anti metabolic syndrome(2181)(2182) and reduced risk of complications of diabetes(2184)(2185)(2189) and cardiovascular disease(2182)(2186) effects on lipid profile(2182)[LDL-non-HDL-C, total cholesterol, triglycerides and Lp(a), and elevating HDL-C concentrations], obesity(2183), glucose intolerance(2183), and oxidative stress(2183), body weight(2187), insulin and leptin sensitivity(2187)
through its antihyperglycemic(2183)(2189) and hypolipidemic(2183)(2188) metabolisms and antioxidant(2188) and anti-inflammatory activities(2181).

Made From Fresh Fruits And Vegetable Recipes
Secret To A Vibrant And Healthy Lifestyle
That You Can Find Easily At The Comfort Of Your Kitchen.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women WithPolycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(1246) [Clinical study of area of Jiangsu province of polycystic ovarian syndrome correlation distribution of traditional Chinese medicine syndrome type and improper diet]. [Article in Chinese] by Feng Y, Gao YP.(PubMed)
(1247) [Preliminary study on relationship of disease-syndrome-symptom of ovulatory disorder infertility based on factor analysis]. [Article in Chinese] by Li M, Ma K, Shan, J.(PubMed)
(1247a) A Comprehensive Treatment of Polycystic Ovarian Syndrome (PCOS) bny by Liqin Zhao
(2072) Spleen, Earth
(2073) [Research on building method of spleen kidney Yang deficiency diarrhea rats model]. [Article in Chinese] by Pan X, Hu CJ, Geng YY, Zhao L, Wu WH, Wu XQ, Zhong ZD.(PubMed)
(2074) Treatment of an elderly patient with acute abdominal pain with traditional Korean medicine by Son CG1.(PubMed)
(2075) Shenzhu Tiaopi granule combined with lifestyle intervention therapy for impaired glucose tolerance: a randomized controlled trial by Fang Z1, Zhao J2, Shi G3, Shu Y3, Ni Y3, Wang H3, Ding L3, Lu R3, Li J3, Zhu X3, Cheng S4, Zhang X3, Liu Y5, Wang J6, Luo Y3, Fan Q3, Guo C3, Jiang T3, Wu Q3, Fan L3, Ling H3, Cui L3, Luo Y3, Yang H3, Anderson RM7.(PubMed)
(2075) Direct moxibustion to treat spleen qi and yang deficiency fatigue: a pilot study by Thorne TL1, Hanes DA2, Wild H3, Colbert A4.(PubMed)
(2076) [Clinical observation on fuzhong (supporting the middle-jiao) manipulation of tuina for infantile anorexia]. [Article in Chinese] by Wang YY, Liu XY.(PubMed)
(2077) [Effect of umbilicus moxibustion therapy on physical conditions of yang-deficiency volunteers]. [Article in Chinese] by Zhang YY1.(PubMed)
(2078) Analysis of the restorative effect of Bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model using (1)H-NMR-based metabonomics by Zheng XF1, Tian JS2, Liu P3, Xing J1, Qin XM1.(PubMed)
(2079) [1H NMR based metabolomics study of bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model]. [Article in Chinese] by Chen L, Xiang H, Xing J, Tian JS, Qin XM, Du GH.(PubMed)
(2080) Bufei Jianpi granules improve skeletal muscle and mitochondrial dysfunction in rats with chronic obstructive pulmonary disease by Dong Y1,2, Li Y3,4,5, Sun Y6, Mao J7, Yao F8, Tian Y9, Wang L10, Li L11, Li S12,13,14, Li J15,16,17(PubMed)
(2081) [Clinical observation on obesity and hyperlipidemia of liver qi stagnation and spleen deficiency pattern in female patients treated with combined therapy of acupuncture and tapping method]. [Article in Chinese] by Wu B, Liu ZC, Xu B.(PubMed)
(21773) Piperine inhibits the activities of platelet cytosolic phospholipase A2 and thromboxane A2 synthase without affecting cyclooxygenase-1 activity: different mechanisms of action are involved in the inhibition of platelet aggregation and macrophage inflammatory response by Son DJ1, Akiba S2, Hong JT3, Yun YP4, Hwang SY5, Park YH6, Lee SE7.(PubMed)
(2174) Piperine, a Bioactive Component of Pepper Spice Exerts Therapeutic Effects on Androgen Dependent and Androgen Independent Prostate Cancer Cells by Samykutty A1, Shetty AV, Dakshinamoorthy G, Bartik MM, Johnson GL, Webb B, Zheng G, Chen A, Kalyanasundaram R, Munirathinam G.(PubMed)
(2175) Antioxidant potential of spices and their active constituents by Srinivasan K1.(PubMed)
(2176) Inhibitory effects of black pepper (Piper nigrum) extracts and compounds on human tumor cell proliferation, cyclooxygenase enzymes, lipid peroxidation and nuclear transcription factor-kappa-B by Liu Y1, Yadev VR, Aggarwal BB, Nair MG.(PubMed)
(2177) Antispasmodic effect of Piper nigrum fruit hot water extract on rat ileum by Naseri MK1, Yahyavi H.(PubMed)
(2178) Pharmacological basis for the medicinal use of black pepper and piperine in gastrointestinal disorders by Mehmood MH1, Gilani AH.(PubMed)
(2179) Blood pressure lowering and vasomodulator effects of piperine by Taqvi SI1, Shah AJ, Gilani AH.(PubMed)
(2180) Black pepper(MDidea)
(2181) Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis by Panahi Y1, Hosseini MS2, Khalili N2, Naimi E2, Majeed M3, Sahebkar A4.(PubMed)
(2182) Lipid-modifying effects of adjunctive therapy with curcuminoids-piperine combination in patients with metabolic syndrome: results of a randomized controlled trial by Panahi Y1, Khalili N2, Hosseini MS2, Abbasinazari M3, Sahebkar A4.(PubMed)
(2183) Amelioration of obesity, glucose intolerance, and oxidative stress in high-fat diet and low-dose streptozotocin-induced diabetic rats by combination consisting of "curcumin with piperine and quercetin" byKaur G1, C M.(PubMed)
(2184) Piperine, a natural bioenhancer, nullifies the antidiabetic and antioxidant activities of curcumin in streptozotocin-diabetic rats by Arcaro CA1, Gutierres VO1, Assis RP1, Moreira TF1, Costa PI1, Baviera AM1, Brunetti IL1.(PubMed)
(2185) Elucidation of the Inhibitory Effect of Phytochemicals with Kir6.2 Wild-Type and Mutant Models Associated in Type-1 Diabetes through Molecular Docking Approach by Jagadeb M1, Konkimalla VB2, Rath SN1, Das RP1.(PubMed)
(2186) Piperine attenuates cardiovascular, liver and metabolic changes in high carbohydrate, high fat-fed rats by Diwan V1, Poudyal H, Brown L.(PubMed)
(2187) Mitigating efficacy of piperine in the physiological derangements of high fat diet induced obesity in Sprague Dawley rats by BrahmaNaidu P1, Nemani H2, Meriga B3, Mehar SK4, Potana S2, Ramgopalrao S5.(PubMed)
(2188) Efficacy of piperine, an alkaloidal constituent from Piper nigrum on erythrocyte antioxidant status in high fat diet and antithyroid drug induced hyperlipidemic rats by Vijayakumar RS1, Nalini N.(PubMed)
(2189) Screening of antidiabetic and antihyperlipidemic potential of oil from Piper longum and piperine with their possible mechanism by Kumar S1, Sharma S, Vasudeva N.(PubMed)

Tuesday, January 26, 2016

The Marvelous smoothie of Cooked Fennel, Ginger and Almond Milk for reduced risk and treatment of Dysmenorrhea

Kyle J. Norton(Scholar and Master of Nutrients) all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


The smoothie for ameliorated symptoms and treatment of dysmenorrhea
Yield: 2 serving (about 8 ounce each)
1/2 cup cooked fennel
1 large slice of ginger
1 1/2 cups of almond milk

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately


The finding the natural ingredients for prevention and treatment of dysmenorrhea with little or no adverse effects to replace the conventional medicine have been facing many obstacles. Many initially potentially therapeutic values working in animal studies does not produce the same effectiveness in human trials.

Dysmenorrhea (painful menstruation) is defined as a condition of severe uterine pain during menstruation. Some women may experience periodic pains during or prior to, or after menstrual periods in the lower abdomen as resulting of over production of certain hormones in the prostaglandins family.

Recent studies of the combination of fennel(1), ginger(4) and almond milk may have a potential and therapeutic values for reduced painful symptoms and treatment of dysmenorrhea.
Fennel is a species of Foeniculum Vulgare, belong to the family Apiaceae (Umbelliferae), and native to to the shores of the Mediterranean. It is now widely cultivated all around the globe to use as food and herb.
According to the Babol University of Medical Sciences and Health Services, in a total of 60 virgin girls with complaints ofdysmenorrhoea, 30 mg fennel extract, four times a day for three days from start of their menstrual period significantly reduced menstrual pain(1).

Dr. Modaress Nejad V and Dr.Asadipour M. in comparison of the effectiveness of fennel and mefenamic acid on pain intensity in dysmenorrhoea, said," In the fennel group, 80% of girls and in the mefenamic acid group, 73% of girls showed complete pain relief or pain decrease", in a study of groups of high-school girls, suffering dysmenorrhoea randomized to receive fennel extract (n = 55) or mefenamic acid (n = 55) for 2 months(2).

Furthermore, the University of Tehran Medical Sciences in the stutdy of uterine contraction as a model for dysmenorrhea, fennel essential oil (FEO), reduced the frequency of contractions induced by (prostaglandin hormone) PGE-2 with little or no adverse effects(3).

Ginger (Zingiber officinale) or ginger root is the genus Zingiber, belongings to the family Zingiberaceae, native to Tamil, used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
According to Dr. Backon J. at the Mount Pleasant Hospital Addiction Studies Foundation, ginger, may be effective for treatment of pain and cramping of dysmenorrhea as a thromboxane synthetase(antiplatelet drugs) inhibitor in activation of the endorphin receptors(6).

Dr. Halder A in the study of the muscle relaxation versus intake of ginger powder on dysmenorrhoea, said," in treating symptoms of dysmenorrhoea, gingerpowder has efficacy superior to progressive muscle relaxation."(5).

Omega-3 polyunsaturated fatty acids found abundantly in almond may be adding to the curable ingredients for reduced painful symptoms and treatment of Primary Dysmenorrhea(7). According to the Semnan University of Medical Sciences, oral administration of supplementation with omega-3 fatty acids not only reduced the symptom intensity but also reduced doses of ibuprofen for women with dysmenorrhea(7).
In a double-blind, randomized clinical trial study of management of premenstrual syndrome and dysmenorrhea, application of Omega 3 fatty acids significantly reduce dysmenorrhea and the emotional symptoms of premenstrual syndrome(8).

In support of the above efficacy, the Children's Hospital Medical Center study showed a positive result of dietary supplementation with omega-3 fatty acids in inhibition of dysmenorrheain adolescents(9).


Taking altogether, women who are at increased risk of dysmenorrhea due to menstrual irregularity .....should drink at least one serving daily and who are with dysmenorrhea should drink the smoothie as much as they can, depending to digestive toleration.
Change life style and diet pattern are also recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


References
(1) Effect of fennel on pain intensity in dysmenorrhoea: A placebo-controlled trial by Omidvar S1, Esmailzadeh S, Baradaran M, Basirat Z(PubMed)
(2) Comparison of the effectiveness of fennel and mefenamic acid on pain intensity in dysmenorrhoea by Modaress Nejad V1, Asadipour M.(PubMed)
(3) The effect of fennel essential oil on uterine contraction as a model for dysmenorrhea, pharmacology and toxicology study by Ostad SN1, Soodi M, Shariffzadeh M, Khorshidi N, Marzban H.(PubMed)(4) [Dysmenorrhea: a study of affected factors and approaches to relief among female students at a college in southern Taiwan].[Article in Chinese] by Chen CK1, Huang YP, Fang HL, Huang YY.(PubMed)
(5) Effect of progressive muscle relaxation versus intake of ginger powder on dysmenorrhoea amongst the nursing students in Pune by Halder A1.(PubMed)
(6) Mechanism of analgesic effect of clonidine in the treatment of dysmenorrhea by Backon J1.(PubMed)
(7) Effect of omega-3 fatty acids on intensity of primary dysmenorrhea by Rahbar N1, Asgharzadeh N, Ghorbani R.(PubMed)
(8) Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea by Sampalis F1, Bunea R, Pelland MF, Kowalski O, Duguet N, Dupuis S.(PubMed)
(9) Supplementation with omega-3 polyunsaturated fatty acids in the management of dysmenorrhea in adolescents by Harel Z1, Biro FM, Kottenhahn RK, Rosenthal SL.(PubMed)