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Wednesday, May 23, 2012

Daidzein and genistein glucuronides are weakly estrogenic and activate human natural killer cells

  Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health

In the study to assess "Daidzein and genistein glucuronides in vitro are weakly estrogenic and activate human natural killer cells at nutritionally relevant concentrations" by Zhang Y, Song TT, Cunnick JE, Murphy PA, Hendrich S., posted in US National Library of Medicine National Institutes of Health, researchers found that The glucuronides only inhibited NK cytotoxicity at 50 micromol/L. Isoflavones, and especially the isoflavone glucuronides, enhanced activation of NK cells by interleukin-2 (IL-2), additively. At physiological concentrations, DG and GG were weakly estrogenic, and they activated human NK cells in nutritionally relevant concentrations in vitro, probably at a site different from IL-2 action.


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