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Saturday, May 5, 2012

Effect of dietary soy intake on breast cancer risk

 Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health

In the study of "Effect of dietary soy intake on breast cancer risk according to menopause and hormone receptor status" by  Cho YA, Kim J, Park KS, Lim SY, Shin A, Sung MK, Ro J., posted in US National Library of Medicine National Institutes of Health, researchers found that The estimated mean intakes of total soy and isoflavones from this study population were 76.5 g per day and 15.0 mg per day, respectively. Using a multivariate logistic regression model, we found a significant inverse association between soy intake and breast cancer risk, with a dose-response relationship (odds ratios (OR) (95% confidence interval (CI)) for the highest vs the lowest intake quartile: 0.36 (0.20-0.64)). When the data were stratified by menopausal status, the protective effect was observed only among postmenopausal women (OR (95% CI) for the highest vs the lowest intake quartile: 0.08 (0.03-0.22)). The association between soy and breast cancer risk did not differ according to estrogen receptor (ER)/progesterone receptor (PR) status, but the estimated intake of soy isoflavones showed an inverse association only among postmenopausal women with ER+/PR+ tumors.

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