Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women

 Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health

In the study of "Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women", posted in US National Library of Medicine National Institutes of Health, indicated that Soy protein (60 g containing 45 mg isoflavones) given daily for 1 mo significantly (P < 0.01) increased follicular phase length and/or delayed menstruation. Midcycle surges of luteinizing hormone and follicle-stimulating hormone were significantly suppressed during dietary intervention with soy protein. Plasma estradiol concentrations increased in the follicular phase and cholesterol concentrations decreased 9.6%. Similar responses occur with tamoxifen, an antiestrogen undergoing clinical trial as a prophylactic agent in women at high risk for breast cancer. These effects are presumed to be due to nonsteroidal estrogens of the isoflavone class, which behave as partial estrogen agonists/antagonists. The responses to soy protein are potentially beneficial with respect to risk factors for breast cancer and may in part explain the low incidence of breast cancer and its correlation with a high soy intake in Japanese and Chinese women.

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