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Friday, July 20, 2012

Antihyperglycemic effect of biochanin A, a soy isoflavone

 Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health

In the evaluation of Antihyperglycemic effect of biochanin A, a soy isoflavone, on streptozotocin-diabetic rats, posted in PubMed, indicated that Oral administration of biochanin A (10mg/kg body weight) or glibenclamide (600 μg/kg body weight) in 0.5% dimethyl sulfoxide, for 45 days, prevented the above changes and improved towards normality. In addition, protection against body weight loss of diabetic animals by biochanin A was also observed. No significant effect was observed in normal rats treated with biochanin A (10mg/kg bodyweight). These results showed that biochanin A has potential antihyperglycemic activity at a dose of 10mg/kg bodyweight in streptozotocin induced diabetic rats.


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