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Sunday, July 22, 2012

lignans and isoflavones and breast cancer risk

Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health

In the study to investigate whether phytoestrogen intake is associated with reduced breast cancer risk, using a novel phytoestrogen database, posted in PubMed, researchers found that lignan intake was associated with a reduced breast cancer risk (Q5 vs. Q1 MVOR: 0.81, 95% CI: 0.65, 0.99); however, following stratification by BMI, this reduction in risk was statistically significant only among overweight (BMI > 25) women. Total phytoestrogen intake was also associated with a risk reduction among overweight women only. Among pre-menopausal women, total phytoestrogen intake was associated with a significant reduction in breast cancer risk among overweight women only (Q5 vs. Q1 MVOR: 0.51, 95% CI: 0.30, 0.87). Among post-menopausal women, no statistically significant association was observed between breast cancer risk and isoflavones or lignans.

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