Posted by Chantel. M studies contributed by US National Library of Medicine
National Institutes of Health
In the study to evaluate the equol effects on reproductive and non-reproductive
endpoints in mice, posted in PubMed.
Ovariectomized age-matched (30-day-old) female
C57BL/6 mice were fed phytoestrogen-free diets and given a racemic
mixture of equol by daily injections (0, 4, 8, 12, or 20 mg [kg body
weight](-1) day(-1)) or in the diet (0, 500, or 1,000 ppm) for 12
days.showed that equol is a weak estrogen with modest effects on
endpoints regulated by
estrogen receptor alpha when present at serum levels seen in rodents fed
soy-based diets, but quantities present in humans may not be sufficient
to induce estrogenic effects, although additive effects of equol with
other phytoestrogens may occur.
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