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Sunday, October 28, 2012

Estrogenicity of the isoflavone metabolite equol on reproductive and non-reproductive organs

Posted by Chantel. M studies contributed by  US National Library of Medicine National Institutes of Health

In the study to evaluate the equol effects on reproductive and non-reproductive endpoints in mice, posted in PubMed. Ovariectomized age-matched (30-day-old) female C57BL/6 mice were fed phytoestrogen-free diets and given a racemic mixture of equol by daily injections (0, 4, 8, 12, or 20 mg [kg body weight](-1) day(-1)) or in the diet (0, 500, or 1,000 ppm) for 12 days.showed that equol is a weak estrogen with modest effects on endpoints regulated by estrogen receptor alpha when present at serum levels seen in rodents fed soy-based diets, but quantities present in humans may not be sufficient to induce estrogenic effects, although additive effects of equol with other phytoestrogens may occur.

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