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Monday, December 17, 2012

Natto and Escalated regeneration in sciatic nerve

Posted by Chantel M. research contributed  US National Library of Medicine National Institutes of Health 
In the study to examine the effect of Natto on transplanted human amniotic fluid mesenchymal stem cells (AFS), Animals were categorized into four groups: Group I: no treatment; Group II: fed with Natto (16 mg/day for 7 consecutive days); Group III: AFS embedded in fibrin glue; Group IV: Combination of group II and III therapy, posted in PubMed, indicated that the combined therapy caused the most significantly beneficial effects. Administration of Natto suppressed the inflammatory responses and correlated with decreased AFS and Schwann cell apoptosis. The decreased AFS apoptosis was in line with neurological improvement such as expression of early regeneration marker of neurofilament and late markers of S-100 and decreased vacuole formation. Administration of either AFS, or Natto, or combined therapy augmented the nerve regeneration.

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