Posted by Chantel M. Contributed by US National
Library of Medicine National Institutes of Health
In the study of increasingly natural products particularly flavonoids are being explored
for their therapeutic potentials in reducing bone loss and maintaining
bone health, posted in PubMed, redeachers found that Genistein inhibits tyrosine kinases and inhibits DNA topoisomerases I
and II, and may act as an antioxidant. Genistein enhances osteoblastic
differentiation and maturation by activation of ER, p38MAPK-Runx2 and
NO/cGMP pathways, and it inhibits osteoclast formation and bone
resorption through inducing osteoclastogenic inhibitor osteoprotegerin
(OPG) and blocking NF-κB signalling. Icariin, a prenylated flavonol
glycoside isolated from Epimedium herb, stimulates osteogenic
differentiation of BMSCs and inhibits bone resorption activity of
osteoclasts. Icariin, whose metabolites include icariside I, icariside
II, icaritin and desmethylicaritin, has no estrogenic activity. However,
icariin is more potent than genistein in promoting osteogenic
differentiation and maturation of osteoblasts. The existence of a prenyl
group on C-8 of icariin molecular structure has been suggested to be
the reason why icariin is more potent than genistein in osteogenic
activity.
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