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Wednesday, January 9, 2013

Genistein reverses severe pulmonary hypertension and prevents right heart failure

 Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health

Pretreatment with a phytoestrogen genistein, a soy phytoestrogen has been shown to attenuate the development of pulmonary hypertension (PH). In the study of whether genistein could also reverse preexisting established PH and prevent associated right heart failure (RHF). PH was induced in male rats by 60 mg/kg of monocrotaline, posted in PubMed, researchers at the University of California Los Angeles School of Medicine, Department of Anesthesiology, showed that Genistein reversed right ventricular hypertrophy (right ventricular hypertrophy index, 0.35±0.029 versus 0.70±0.080 in RHF), inhibited neonatal rat ventricular myocyte hypertrophy, and restored PH-induced loss of capillaries in the right ventricle. These improvements in cardiopulmonary function and structure resulted in 100% survival by day 30. Genistein restored PH-induced downregulation of estrogen receptor-β expression in the right ventricle and lung.

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