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Thursday, January 10, 2013

Icariin is more potent than genistein in Osteoblast differentiation and Mineralization

Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health

Genistein, an isoflavone abundant in soy, and icariin, a prenylated flavonol glycoside isolated from Epimedium Herb, have both been identified to exert beneficial effects in preventing postmenopausal bone loss,. In the study of Icariin is more potent than genistein in promoting osteoblast differentiation and mineralization in vitro, posted in PubMed, researchers at the Lanzhou Command of CPLA, found that although future in vivo studies are required to investigate whether icariin is more efficient in improving bone mass and/or preventing bone loss, our in vitro studies have demonstrated that icariin has a stronger osteogenic activity than genistein. In addition, while the prenyl group on C-8 of icariin could be the active group that takes part in osteoblastic differentiation and explains its greater potency in osteogenesis, mechanisms of action, and reasons for the relative potency of icariin versus genistein need to be further studied.

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