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Thursday, January 3, 2013

Intralipid prevents and rescues fatal pulmonary arterial hypertension and right ventricular failure

 Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health

In the investigation of the therapeutic potential of Intralipid (ILP), a source of parenteral nutrition for patients, contains γ-linolenic acid and soy-derived phytoestrogens that are protective for lungs and heart. in preventing and rescuing monocrotaline-induced PAH and RV dysfunction, posted in PubMed, researchers found that the beneficial effects of ILP in PAH seem to result from the interplay of various factors, among which preservation and/or stimulation of angiogenesis, suppression and/or reversal of inflammation, fibrosis and hypertrophy, in both lung and RV, appear to be major contributors. In conclusion, ILP not only prevents the development of PAH and RV failure but also rescues preexisting severe PAH.

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