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Wednesday, March 6, 2013

Fermented soybean and apoptosis of human hepatocellular carcinoma Hep 3B cells

Posted by Chantel M. research contributed by US National Library of Medicine National Institutes of Health   

SC-1, the aqueous phase of soybean fermentation products by bacteria (Bacillus subtilis and Bacillus brevis), significantly inhibited the growth and clonogenesity of human hepatocellular (Hep 3B), mouse hepatocellular (ML-1), and human colorectal (HCT 116 and HT-29) carcinoma cells. Cytotoxicity of SC-1 in Hep 3B cells was through the process of apoptosis characterizing by increase in cell population of sub-G(1) phase, fragmentation of DNA, and change of nuclear morphology, according to the study by Department of Nursing, Chang Jung Christian University posted in PubMed,

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