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Saturday, April 13, 2013

Isoflavonoids inhibit on rat prostate testosterone 5α-reductase

 Posted by Chantel M. research contributed by US National Library of Medicine National Institutes of Health 


Testosterone 5α-reductase inhibitors represent important therapeutic drugs for use against androgen-dependent diseases such as benign prostatic hyperplasia, male pattern baldness, and acne. According to the Daegu Haany University, in the searching inhibitors of rat prostate testosterone 5α-reductase in the cultured broths of many kinds of soil bacteria, and have found that cultured soybean-casein digest broths of certain bacterial strains have a potent inhibitory effect on the enzyme, found that Genistein, biochanin A, equol, and 3',4',7-trihydroxyisoflavone showed considerably higher inhibitory effects whereas daidzein, formononetin, glycitein, prunetin, ipriflavone, and 4',7-dimethoxyisoflavone showed lower inhibitory effects. The IC(50) values of genistein, biochanin A, equol, 3',4',7-trihydroxyisoflavone, and riboflavin, a positive control, for rat prostate testosterone 5α-reductase were 710 μm, 140 μm, 370 μm, 690 μm, and 17 μm, respectively. Daidzein, genistein, biochanin A, formononetin, and equol are already known to be testosterone 5α-reductase inhibitors, but this is the first characterization of 3',4',7-trihydroxyisoflavone as an inhibitor of the enzyme, posted in PubMed.

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1 comment:

  1. Several studies about this one is still under investigatiion and will go for further testing. Until now, prostate cancer is suddenly increasing for men who reaches the age of fifty and above according to the article about saw palmetto and several symptoms are not visible until you reach that age.

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