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Wednesday, May 22, 2013

Isoflavones on tumor growth and cachexia in newly established cachectic mouse models carrying human stomach cancers

Posted by Chantel Martiromo. research contributed by PubMed
Cachexia, a negative prognostic factor, worsens a patient's quality of life. According to the study by the National Cancer Center Research Institute, posted in PubMed, isoflavones reduced their proliferation, implying that the isoflavones possess antiproliferative effects of these cancer cell lines. Isoflavone treatment on the models induced tumor cytostasis, attenuation of cachexia, and prolonged survival whereas discontinuation of the treatment resulted in progressive tumor growth and weight loss. The inhibitory effects of tumor growth and weight loss by isoflavones were graded as soy isoflavone aglycone AglyMax > daidzein > genistein.

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