Posted by Chantel Martiromo, research contributed by PubMed
Polycystic ovary syndrome (PCOS), also referred to as Stein-Leventhal syndrome, is one of the most common endocrinopathies. According to the study by the University of Texas, posted in PubMed, indeed, male relatives may suffer from insulin resistance, obesity,
diabetes mellitus, and cardiovascular disease. Therefore, recognition of
in men is important, since pharmacologic treatments identified for women
with PCOS may alleviate metabolic problems related to insulin
resistance and its sequelae in men with a similar underlying defect. We
suggest that first-degree relatives of patients with PCOS should be
examined not only for phenotypic features characteristic of PCOS but
also for biochemical evidence of hyperinsulinemia and hyperandrogenism.
In addition to examining these individuals for obesity, the women should
be evaluated for hirsutism and the men should be screened for
early-onset male-pattern alopecia and excess hairiness. Serologic
evaluation should included the ratio of fasting levels of glucose to
insulin, a glucose tolerance test, the free testosterone level and the
sex hormone-binding globulin level. Finally, both male and female
first-degree relatives of patients with PCOS should be tested for the
underlying molecular defect(s) of this condition, once it is identified.
As new treatments for PCOS emerge, e.g. insulin-sensitizing drugs, it
will be important to determine if these treatments have beneficial
effects on the metabolic symptoms and complications in all afflicted
patients, regardless of gender.
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