Green tea and Endometrial cancer

Posted by Chantel Martiromo

The incidence of endometrial cancer among white women are higher in comparison of black women. According to the statistic, the risk of endometrial cancer among women is 1 in 7000. Every year, about 40,000 women in US are diagnosed with the disease. Women who carry certain mutation genes, such as  BRCA1 or the BRCA2 are associated to increased risk of endometrial cancer.

Endometrial cancer is a late adulthood cancer defined as a condition of which the cells of the endometrial lining of uterus have growth uncontrollable or become cancerous as a result of the alternation of cells DNA. It's the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer.

Green tea contains more amount of antioxidants than any drinks or food with the same volume, and is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China. Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Because of their health benefits, they have been cultivated for commercial purposes all over the world. The University of Bristol study showed that there is some positive evidence for risk reduction of  endometrial cancers with green tea consumption(24). (-)-Epigallocatechin-3-gallate (EGCG), a major polyphenol in green tea, inhibited endometrial cancer cell line through inhibiting ERK activation and inducing apoptosis via ROS generation and p38 activation(25). The a population-based case-control study in urban Shanghai indicated that the reduction of risk of endometrial cancer may be  only limit to premenopausal women(26)). Some studies suggested that  tea consumption may reduce the risk of endometrial cancer but further prospective studies are needed(27).

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References
(24) Green tea and green tea catechin extracts: an overview of the clinical evidence by Johnson R¹, Bryant S, Huntley AL(PubMed)
(25) (-)-Epigallocatechin-3-gallate induces apoptosis in human endometrial adenocarcinoma cells via ROS generation and p38 MAP kinase activation by Manohar M¹, Fatima I, Saxena R, Chandra V, Sankhwar PL, Dwivedi A(PubMed)
(26) [Green tea consumption and the risk of endometrial cancer: a population-based case-control study in urban Shanghai].[Article in Chinese] by Gao J¹, Xiang YB, Xu WH, Shao CX, Ruan ZX, Cheng JR, Shu XO, Gao YT(PubMed)
(26) Tea consumption and risk of endometrial cancer: a metaanalysis by Tang NP¹, Li H, Qiu YL, Zhou GM, Ma J(PubMed)
(27) Caffeinated coffee, decaffeinated coffee and endometrial cancer risk: a prospective cohort study among US postmenopausal women by Giri A¹, Sturgeon SR, Luisi N, Bertone-Johnson E, Balasubramanian R, Reeves KW(PubMed)