Herbal Sophora flavescens & Hair Loss

Posted by Chantel Martiromo

Decreased hormonal secretions due to aging stimulates the production of the enzyme 5-alpha reductase to converse testosterone to gihydro-testosterones DHT, affecting hair to grow back thinner or not grown back at all.  DHT shrinks the follicles, causing hair thins and hair receded at the forehead, crown and temple for men and thins over the entire scalp for women. Herbal treatment for hair loss has existed throughout human history, but epidemiological studies, linking herbs effectiveness in treating hair loss have produced inconsistent results.

Androgenetic alopecia is a common hair loss in men and women. In men, it causes baldness patterns, receding at the forehead. In women, the hair becomes thinner all over the head, and the hairline does not recede.
Sophora flavescens is a species of  genus Sophora, belonging to family Fabaceae. The herb has been used in traditional medicine for treatments of viral hepatitis, enteritis, cancer, viral myocarditis, gastrointestinal hemorrhage etc. In the experiment of topical application of Sophora flavescens extract in C57BL/6 mice, enhanced on hair growth may be mediated through the regulation of  growth factors in dermal papilla cells and inhibited the type II 5alpha-reductase activity(11).
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References 
(11) The hair growth promoting effect of Sophora flavescens extract and its molecular regulation by Roh SS, Kim CD, Lee MH, Hwang SL, Rang MJ, Yoon YK.(PubMed)