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The smoothie for reduced risk and treatment of cervical cancer
Yield: 2 serving (about 8 ounce each)
3/4 cup blueberry
3/4 cup carrot
1 cup green tea drink (Make from 4 grams of green tea and a cup of hot water lipped for 5 minutes, and set aside for cooling to room temperature)
1. Place all ingradietns in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately
The dream of finding the natural ingredient for prevention and treatment of cervical cancer without adverse effects in replacement of conventional medication has not been abated. Some ingredients have to discard due to it can not produce the same potent results in human trials.
Recent studies suggested that green tea(1), blueberry(5) and carrot(8) may have a potential and therapeutic value for reduced risk and treatment of cervical cancer probably due to theirs' phytochemicals effect in ameliorated proliferation of cancer cell expression.
Cervical cancer is malignant neoplasm of the cervix uteri or cervical area caused by abnormal cells growth with alternation of cells DNA.
Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years used in traditional Chinese medicine for treatment of variety of diseases, including cancers and heart diseases.(-)-epigallocatechin-3-gallate (EGCG), a major constituent of green tea, in human papillomavirus (HPV)-16 associated cervical cancer cell line, upregulated the genes expression in inhibition of cervical cancer cell growth through induction of apoptosis and cell cycle arrest(1).
The in the study of green tea effect in cervical cancer suggested that EGCG reactivate known tumor-suppressor genes (TSGs) in HeLa cells by by targeting epigenetic alterations including DNA methylation(2).
Green tea extract, strongly inhibited the growth of HeLa xenografts(a cancer cell line) in animal model when used conjunction with lysine, ascorbic acid, proline and other nutrients(3).
Dr. Shan HM and the research team at the Peking University said,"..., catechins interfere with the proper subcellular localization of PLK1, lead to cell-cycle arrest in the S and G2M phases, and induce growth inhibition of several human cancer cell types, such as breast adenocarcinoma (MCF7), lung adenocarcinoma (A549), and cervical adenocarcinoma (HeLa)"(4).
Blueberry, a flower plant, belong to the family Eriaceae and native to Northern America, was also found to process anti cancer properties, through its powerful antioxidant anthocyanin(5)
epidemiological studies suggested.
In the comparison of blueberry and blackcurrant juices on three tumor cell lines; B16F10 (murine melanoma), A2780 (ovarian cancer) and HeLa (cervical cancer), anthocyanin-rich fractions (ARFs) found in the juice exhibited antiproliferative effects through its antioxidant bioactive molecules(5).
According to the University of Mississippi research, ethanol extracts blueberry cultivars strongly inhibited CaSki and SiHa cervical cancer cell lines and MCF-7 and T47-D breast cancer cell line, through interfering to the direct-acting and metabolically activated carcinogens(6).
In fact, researchers at the Clemson University, in the evaluation of juice from strawberry, blueberry, and raspberry fruit showed that fresh juices and organic solvent extracts from the fruits exhibited the the formation of cancer is damage to the genome of a somatic cell producing a mutation in an oncogene or a tumor-suppressor genes(7).
Carrots with abundant carotenoid (α-carotene, β-carotene, and lutein/zeaxanthin) and tocopherol may also be considered for reducing risk and treatment of cervical cancer, according to the Xinjiang Medical Universit(8). As higher serum concentrations of some carotenoids and tocopherols are found to associate to lower risk cervical cancer among Chinese women(8). Frequent intakes of carrot decreased the risk of cervical cancer(11).
In a total of 391 patients with cervical intraepithelial neoplasia (CIN) grade 1-2 lesions, high serum levels of alpha-tocopherol and medium level of serum beta-carotene were associate to the regression and progression of the diseases respectively(9).
The 32 women with incident cervical dysplasia, including cervical intraepithelial neoplasia (CIN) I, CIN II, and CIN III/carcinoma in situ, and 113 control women with normal cervical cytology in case-control study suggested ," among black women, lycopene and perhaps vitamin A may play a protective role in the early stages of cervical carcinogenesis"(10).
The combination of Blue berry, Carrot and Green tea smoothie may hold a key for reduced risk for and treatment of the disease. Women with cervical cancer in any stage should drink as much as they can, depending to the digestive toleration.
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(1) A major constituent of green tea, EGCG, inhibits the growth of a human cervical cancer cell line, CaSki cells, through apoptosis, G(1) arrest, and regulation of gene expression by Ahn WS1, Huh SW, Bae SM, Lee IP, Lee JM, Namkoong SE, Kim CK, Sin JI.(PubMed)
(2) (-)-Epigallocatechin-3-gallate reverses the expression of various tumor-suppressor genes by inhibiting DNA methyltransferases and histone deacetylases in human cervical cancer cells by Khan MA1, Hussain A2, Sundaram MK2, Alalami U1, Gunasekera D2, Ramesh L2, Hamza A2, Quraishi U2.(PubMed)
(4) Identification of green tea catechins as potent inhibitors of the polo-box domain of polo-like kinase 1 by Shan HM1, Shi Y, Quan J.(PubMed)
(5) Antiproliferative and antioxidant properties of anthocyanin rich extracts from blueberry and blackcurrant juice by Diaconeasa Z1, Leopold L2, Rugină D3, Ayvaz H4, Socaciu C5.(PubMed)
(6) Anticarcinogenic Activity of Strawberry, Blueberry, and Raspberry Extracts to Breast and Cervical Cancer Cells by Wedge DE1, Meepagala KM, Magee JB, Smith SH, Huang G, Larcom LL.(PubMed)
(7) Antimutagenic activity of berry extracts by Hope Smith S1, Tate PL, Huang G, Magee JB, Meepagala KM, Wedge DE, Larcom LL.(PubMed)
(8) Serum carotenoid, retinol and tocopherol concentrations and risk of cervical cancer among Chinese women by Zhang YY1, Lu L, Abliz G, Mijit F.(PubMed)
(9) Association between carotenoids and outcome of cervical intraepithelial neoplasia: a prospective cohort study by Fujii T1, Takatsuka N, Nagata C, Matsumoto K, Oki A, Furuta R, Maeda H, Yasugi T, Kawana K, Mitsuhashi A, Hirai Y, Iwasaka T, Yaegashi N, Watanabe Y,Nagai Y, Kitagawa T, Yoshikawa H.(PubMed)
(10) Dietary intake and blood levels of lycopene: association with cervical dysplasia among non-Hispanic, black women by Kanetsky PA1, Gammon MD, Mandelblatt J, Zhang ZF, Ramsey E, Dnistrian A, Norkus EP, Wright TC Jr.(PubMed)
(11) [Hospital epidemiology--a comparative case control study of breast and cervical cancers].[Article in Japanese] by Tajima K1, Hirose K, Ogawa H, Yoshida M, Ohta M.(PubMed)