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Tuesday, November 6, 2012

High-dose daidzein affects growth and development of reproductive organs

 Posted by Chantel M. research contributed  US National Library of Medicine National Institutes of Health   
In the study to explore the effect of the phytoestrogen daidzein on the growth and development of the testis and epididymis in male SD rats, posted in PubMed,  researchers at the Nanjing Normal University, found that the early adult rats showed no significant differences in body weight and testicular and epididymal indexes between the claiclzein groups and the control (P > 0.05), nor did the pubertal rats in epididymal index (P > 0.05). The testicular index differed significantly between the high-dose group (3.21 +/- 0.07) and the normal control (3.71 +/- 0.45) (P < 0.05). The body weight reduced markedly in the high-dose group (P < 0.05), but with no significant differences between the normal control and the other two dose groups (P > 0.05). No obvious changes were observed in epididymal morphology in all the daidzein groups of the early adult and pubertal rats, but high-dose daidzein resulted in smaller testes and impaired spermatogenesis.

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